Validation of the MOG-AR score: a retrospective multicenter study.
Recently, a simple score (the MOG-AR Score), including onset age, sex, onset attack phenotype, use of immunosuppressive therapy, and duration of oral glucocorticoids treatment, has been proposed to identify patients at high relapse risk since onset.11
The aim of this study was to provide the first validation of the MOG-AR Score in a national multicenter cohort and to assess other factors associated with a relapsing disease.
Among patients with Appendicitis, the guidelines recommend laparoscopic appendectomy as the standard surgical approach and support delayed surgery within 24 hours for uncomplicated cases.
For complicated appendicitis, short-course postoperative antibiotics (2–3 days) are advised, and routine interval appendectomy is not recommended except in adults aged ≥35 years following nonoperative management with abscess, to reduce risk of missed neoplasm.
This Special Communication outlines the key questions and evidence-based recommendations of the 2025 update of the WSES Jerusalem Guidelines to support clinicians and health care systems in the diagnosis and treatment of acute appendicitis.
NK cells in neurodevelopment.
Maternal immune activation (MIA) during pregnancy perturbs fetal neurodevelopment, with natural killer (NK) cells emerging as key contributors to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD).
Clinical studies consistently report NK cell dysfunction in ASD patients and their mothers, characterized by altered cytotoxicity, hyperactivation at rest, functional exhaustion on stimulation, and skewed receptor/genetic profiles.
Uterine NK (uNK) cells, indispensable for placental and fetal development, can paradoxically promote NDDs when hyperactivated, releasing granzyme B (GZMB) that disrupts fetal brain structure and function.
Elucidating the MIA-driven ‘uNK/ GZMB–microglia–NDD’ axis is essential to devise preventive strategies for high-risk pregnancies and identify early biomarkers of neurodevelopmental risk. sciencenewshighlights ScienceMission https://www.cell.com/cms/10.1016/j.it.2025.10.001/asset/89cd…ts/gr3.jpg https://sciencemission.com/Janus-face-of-NK-cells
Maternal immune activation (MIA), triggered by infection or inflammation during pregnancy, is a well-recognized risk factor for neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD). Clinical cohort studies and rodent models suggest that natural killer (NK) cells play a significant role in NDD pathogenesis, but the underlying mechanisms remain poorly defined. Here, we summarize the key immune mediators involved in MIA-induced NDDs, emphasizing microglia as a central hub. We then examine emerging evidence implicating aberrant NK cell activation in ASD, underscoring their overlooked contribution to impaired neurodevelopment. Finally, we discuss potential mechanisms of NK cell–microglia crosstalk in NDDs. Elucidating these interactions in the context of MIA will be crucial for developing preventive and therapeutic strategies against inflammation-driven NDDs.
The findings in this study demonstrate that reduced neurofilament light chain levels suggest decreased neuroaxonal damage associated with immune modulation, supporting its potential role in targeting inflammatory processes in CLN1 without fully halting disease progression.
Background and Objectives.
Milkweed has found a new strategy in its epic evolutionary battle with monarch butterflies: upgrading its toxins to outmaneuver the monarch’s resistance. In a new study, published in the Proceedings of the National Academy of Sciences, researchers find that adding a small structural element containing nitrogen and sulfur to milkweed’s toxins circumvents monarchs’ ability to block them. The research sheds light on an underappreciated evolutionary tactic for plants: that not only can they increase their levels of toxicity, they can also structurally innovate to create new classes or subclasses of toxins.
“This structural innovation is a new axis for defining chemical toxins in the natural world,” said co-author Christophe Duplais, associate professor of entomology at Cornell AgriTech, in the College of Agriculture and Life Sciences (CALS). “This very simple modification makes a huge difference in terms of its ecological effect, because now this molecule is toxic to the monarch.”
Milkweed and monarchs have coevolved over millions of years, each building defenses and counter-defenses. One such defense is the monarchs’ ability to block milkweed’s toxins, called cardenolides, from binding to their target enzyme in the monarch’s cells. Monarchs have even evolved to sequester the toxins in their wings, to poison birds that peck at them.
Physicist Jim Al-Khalili explores the incomprehensible scale of the universe. A cosmic journey into the laws of gravity, relativity, and the formation of supergalaxies. Discover how the largest structures shape our understanding of the cosmos itself.
Director: Tim Usborne.
Writers: Jim Al-Khalili, Tim Usborne.
Stars: Prof. Jim Al-Khalili (Physicist, Presenter)
Genre: Science Documentary, Physics, Cosmology.
Country: United Kingdom.
Language: English Also Known As: Secrets of Size: Going Big (BBC)
Release Date: 2022
Filming Location: United Kingdom / Various International Locations.
Synopsis:
In this second episode of the fascinating series Secrets of Size, Professor Jim Al-Khalili takes us on a cosmic journey into the immensity, exploring the largest scale of the universe.
We leave behind the quantum realm to focus on the forces that govern the largest structures: gravity and relativity. Al-Khalili explains how these laws shape the existence of galaxies, galaxy clusters, and the immense supergalaxies.
The episode reveals the incomprehensible scale of the cosmos, where time and space are distorted, and how the study of these giants allows us to understand the origin, evolution, and perhaps the ultimate destiny of the universe itself.
Biomedical engineers from Brown University have developed a new wound dressing material that releases antibiotic drugs only when harmful bacteria are present in a wound. In the new study, published in the journal Science Advances, the researchers show that the material could help rapidly clear wound infections to accelerate healing while reducing the unnecessary use of antibiotics—a major driver of antibiotic resistance and hard-to-treat “superbug” infections that claim tens of thousands of lives worldwide each year.
The new material is a smart hydrogel loaded with an antibiotic cargo that can be placed directly on a wound under a bandage. The hydrogel is sensitive to an enzyme produced by many different types of harmful bacteria.
When the enzyme is present, the hydrogel starts to degrade, releasing the antibiotics trapped inside. But when no harmful bacteria are present, the hydrogel stays intact, safely locking its antibiotic cargo away.
