Biomedical engineers from Brown University have developed a new wound dressing material that releases antibiotic drugs only when harmful bacteria are present in a wound. In the new study, published in the journal Science Advances, the researchers show that the material could help rapidly clear wound infections to accelerate healing while reducing the unnecessary use of antibiotics—a major driver of antibiotic resistance and hard-to-treat “superbug” infections that claim tens of thousands of lives worldwide each year.

The new material is a smart hydrogel loaded with an antibiotic cargo that can be placed directly on a wound under a bandage. The hydrogel is sensitive to an enzyme produced by many different types of harmful bacteria.

When the enzyme is present, the hydrogel starts to degrade, releasing the antibiotics trapped inside. But when no harmful bacteria are present, the hydrogel stays intact, safely locking its antibiotic cargo away.