Among patients with Appendicitis, the guidelines recommend laparoscopic appendectomy as the standard surgical approach and support delayed surgery within 24 hours for uncomplicated cases.

For complicated appendicitis, short-course postoperative antibiotics (2–3 days) are advised, and routine interval appendectomy is not recommended except in adults aged ≥35 years following nonoperative management with abscess, to reduce risk of missed neoplasm.

This Special Communication outlines the key questions and evidence-based recommendations of the 2025 update of the WSES Jerusalem Guidelines to support clinicians and health care systems in the diagnosis and treatment of acute appendicitis.