Lifeboat Foundation

Cirrhosis, hepatitis infection and other causes can trigger liver fibrosis—a potentially lethal stiffening of tissue that, once begun, is irreversible. For many patients, a liver transplant is their only hope. However, research at Cedars-Sinai in Los Angeles may offer patients a glimmer of hope. Scientists there say they’ve successfully reversed liver fibrosis in mice.

Reporting in the journal Nature Communications, the team say they’ve discovered a genetic pathway that, if blocked, might bring fibrosis to a halt.

The three genes involved in this fibrotic process are called FOXM1, MAT2A and MAT2B.

NASA’s Curiosity rover, currently exploring Gale crater on Mars, is providing new details about how the ancient Martian climate went from potentially suitable for life – with evidence for widespread liquid water on the surface – to a surface that is inhospitable to terrestrial life as we know it.

Although the surface of Mars is frigid and hostile to life today, NASA’s robotic explorers at Mars are searching for clues as to whether it could have supported life in the distant past. Researchers used instruments on board Curiosity to measure the isotopic composition of carbon-rich minerals (carbonates) found in Gale crater and discovered new insights into how the Red Planet’s ancient climate transformed.

“The isotope values of these carbonates point toward extreme amounts of evaporation, suggesting that these carbonates likely formed in a climate that could only support transient liquid water,” said David Burtt of NASA’s Goddard Space Flight Center in Greenbelt, Maryland, and lead author of a paper describing this research published October 7 in the Proceedings of the National Academy of Sciences. “Our samples are not consistent with an ancient environment with life (biosphere) on the surface of Mars, although this does not rule out the possibility of an underground biosphere or a surface biosphere that began and ended before these carbonates formed.”

A pioneering technique shows how sound can be used to create entire objects quickly and at once. Researchers at Concordia have developed a novel method of 3D printing that uses acoustic holograms. And they say it’s quicker than existing methods and capable of making more complex objects.

The process, called holographic direct sound printing (HDSP), is described in a recent article in the journal Nature Communications. It builds on a method introduced in 2022 that described how sonochemical reactions in microscopic cavitations regions — tiny bubbles — create extremely high temperatures and pressure for trillionths of a second to harden resin into complex patterns.

Now, by embedding the technique in acoustic holograms that contain cross-sectional images of a particular design, polymerization occurs much more quickly. It can create objects simultaneously rather than voxel-by-voxel.

Discovery advances development of new therapeutic options for cancer and other diseases. A research team led by the University of California, Irvine has engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.

A paper recently published in Nature Catalysis describes how the team created an enzyme called 10–92 that achieves faithful and fast TNA synthesis, overcoming key challenges in previous enzyme design strategies.

Inching ever closer to the capability of natural DNA synthesis, the 10–92 TNA polymerase facilitates the development of future TNA drugs.

Joscha Bach puts forward his radical theory of cyber animism.

Can the natural world be understood in terms of software agents?

Continue reading “A radical theory of consciousness | AI researcher Joscha Bach” »

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The scientific feat, which took more than a decade to complete, is published in the journal Science.

The next step for fully integrated textile-based electronics to make their way from the lab to the wardrobe is figuring out how to power the garment gizmos without unfashionably toting around a solid battery. Researchers from Drexel University, the University of Pennsylvania, and Accenture Labs in California have taken a new approach to the challenge by building a full textile energy grid that can be wirelessly charged. In their recent study, the team reported that it can power textile devices, including a warming element and environmental sensors that transmit data in real-time.

The efficiency and performance of photovoltaics (PVs) have improved significantly over the past decades, which has led to an increase in the adoption of solar technologies. To further enhance the performance of solar cells, energy researchers worldwide have been devising and testing alternative design strategies, leveraging different materials and cell structures.

A new method developed by Penn State biologists allows them to turn stripped-down plant cells into other types of cells, similar to the way stem cells differentiate into different cell types. Using this method, the research team explored the banding patterns that increase the stability of plant cell walls—much like the corrugated patterns in cardboard—and how they are created. Additionally, the researchers revealed how the assembly of these structures can go astray in different mutant plant cells, which they said could ultimately inform methods to break down plant cells for biofuels.