Lifeboat Foundation

Researchers at University of California San Diego have developed and tested a new software package, called Spatial Modeling Algorithms for Reactions and Transport (SMART), that can realistically simulate cell-signaling networks—the complex systems of molecular interactions that allow cells to respond to diverse cues from their environment.

Cell-signaling networks involve many distinct steps and are also greatly influenced by the complex, three-dimensional shapes of cells and subcellular components, making them difficult to simulate with existing tools. SMART offers a solution to this problem, which could help accelerate research in fields across the life sciences, such as systems biology, pharmacology and biomedical engineering.

The researchers successfully tested the new software in biological systems at several different scales, from cell signaling in response to adhesive cues, to calcium release events in subcellular regions of neurons and cardiac muscle cells, to the production of ATP (the energy currency in cells) within a detailed representation of a single mitochondrion.

Amazon announced a major milestone in its electric vehicle transition, officially bringing 20,000 Rivian EDVs (electric delivery vans) into its fleet.

Back in 2019, Amazon announced its Climate Pledge to achieve net-zero carbon emissions by 2040. Part of the Pledge included a partnership with Rivian for 100,000 all-electric delivery vehicles. The goal was to have all EDVs on the road and in the Amazon fleet by 2030.

The first Amazon-Rivian EDV hit the road in 2022, and since then, the vans have made it to thousands of locations across the United States.

The Russian Ministry of Health has announced that it has developed a vaccine against cancer that will be distributed to Russian patients for free from early 2025.

According to TASS, the Russian state-owned news agency, Andrey Kaprin—the General Director of the Radiology Medical Research Center of the Russian Ministry of Health—recently announcement the development on Russian radio.

The vaccine will apparently be used to treat cancer patients, rather than given to the general public to prevent cancer—and it will be personalized to each patient.

AMD’s investment is part of how the chip giant plans to make a dent in the artificial intelligence chip market dominated by Nvidia.

“Engineering” sleeping consciousness could reduce nightmares, treat insomnia—and even be induce specific dreams just for fun.

By Michelle Carr edited by Mark Fischetti

I routinely control my own dreams. During a recent episode, in my dream laboratory, my experience went like this: I was asleep on a twin mattress in the dark lab room, wrapped in a cozy duvet and a blanket of silence. But I felt like I was awake. The sensation of being watched hung over me. Experimenters two rooms over peered at me through an infrared camera mounted on the wall. Electrodes on my scalp sent them signals about my brain waves. I opened my eyes—at least I thought I did—and sighed. Little specks of pink dust hovered in front of me. I examined them curiously. “Oh,” I then thought, realizing I was asleep, “this is a dream.”

For the first time, the “inertial range connecting large and small eddies in accretion disk turbulence” was reproduced.

Black holes cannot be directly detected by ground or space-based telescopes. But the accretion disks of gas, plasma, and dust that orbit them emit detectable electromagnetic radiation, allowing astronomers to infer the presence of black holes.

Continue reading “Supercomputers expose hidden inner disk dynamics of a black hole” »

After its formation, the moon may have been the scene of such immense volcanic activity that its entire crust melted several times and was completely churned through. At that time, the moon orbited significantly closer to Earth than today. The resulting tidal forces heated up its interior and thus powered the violent volcanism. Only Jupiter’s moon Io, by far the most volcanically active body in the solar system, offers comparable conditions.

These new considerations published today in the journal Nature by an international team of researchers from the University of California Santa Cruz, the Max Planck Institute for solar system Research (MPS) and the Collège de France resolve previous contradictions and inconsistencies regarding the age of the moon. According to the researchers, the moon was formed between 4.43 and 4.51 billion years ago. Its crust, however, appears around 80 to 160 million years younger.

The moon is apparently quite reluctant to reveal its age. Attempts to uncover its secret have yielded estimates that lie several hundred million years apart: While some researchers suggest that our cosmic companion was formed 4.35 billion years ago, others date its birth to 4.51 billion years ago.

How do you find and measure nuclear particles, like antineutrinos, that travel near the speed of light?

Antineutrinos are the antimatter partner of a neutrino, one of nature’s most elusive and least understood subatomic particles. They are commonly observed near nuclear reactors, which emit copious amounts of antineutrinos, but they also are found abundantly throughout the universe as a result of Earth’s natural radioactivity, with most of them originating from the decay of potassium-40, thorium-232 and uranium-238 isotopes.

When an antineutrino collides with a proton, a positron and a neutron are produced—a process known as inverse beta decay (IBD). This event causes scintillating materials to light up, making it possible to detect these antineutrinos; and if they can be detected, they can be used to study the properties of a reactor’s core or Earth’s interior.

Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell nuclei all at the same time. The method, called ChIP–DIP (Chromatin ImmunoPrecipitation Done In Parallel), is a versatile tool for understanding the inner workings of the nucleus during different contexts, such as disease or development.

The research was conducted in the laboratory of Mitchell Guttman, professor of biology, and is described in a paper that appears in the journal Nature Genetics.

Nearly all cells in the human body contain the same DNA, which encodes the blueprint for creating every cell type in the body and directing their activities. Despite having the same genetic material, different cell types express unique sets of proteins, allowing for the various cells to perform their specialized functions and to adapt to conditions within their environments. This is possible because of careful regulation within the nucleus of each cell and involves thousands of regulatory proteins that localize to precise places in the nucleus.