Maureen A. Su find the epigenetic regulator UTX complexes with transcription factors TCF1 and STAT3 to promote pathogenicity of long-lived, stem-like progenitor T cells in models of type 1 diabetes (T1D)
1Department of Microbiology, Immunology, and Molecular Genetics, UCLA David Geffen School of Medicine, Los Angeles, California, USA.
2Department of Pediatrics and.
3Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sunny Y. Wong & team characterize gene expression changes that occur during acne pathogenesis and identify a therapeutic that reduces acne-like pustule formation in a mouse model of high fat diet-induced folliculitis:
The image shows prominent neutrophilic pustules from ear skin of the mouse model, stained for the neutrophil marker Ly6G (green) and KRT14 (red).
Address correspondence to: Sunny Y. Wong or Joseph S. Durgin, Department of Dermatology, University of Michigan, 1,500 E. Medical Center Dr., Ann Arbor, Michigan 48,109, USA. Email: [email protected] (SYW); [email protected] (JSD).
Benfey et al. find that norepinephrine shifts the visual response selectivity of optic tectal neurons in the Xenopus tadpole to favor threatening loom stimuli over more neutral, randomly drifting dots. Mechanistically, norepinephrine induces radial astrocyte activation and glial release of ATP/adenosine, resulting in reduced excitatory neurotransmission and selectivity shift.
The expert council of the Japanese Ministry of Health has approved two regenerative medicine drugs based on induced pluripotent stem cells (iPSCs) — a cure for Parkinson’s disease and heart failure. If the health minister approves the experts’ decision, Japan will become the first country in the world to allow the commercial sale of such products — almost 20 years after the discovery of the technology itself.
Japan’s health ministry said on Thursday a panel of specialists had endorsed Sumitomo Pharma’s iPS cell-derived treatment for Parkinson’s disease, paving the way for the world’s first medical products based on the technology.
