Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 15

Get the latest international news and world events from around the world.

Log in for authorized contributors

Switching risk and protective alleles improves Alzheimer’s-disease-like signatures and disruptions in mice

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive degradation of brain cells, as well as an associated decline in memory and other mental functions. Earlier research found that different forms (i.e., alleles) of a gene known as apolipoprotein E (APOE) are associated with an increased or decreased risk of developing AD.

The APOE gene can be mutated into different variants (i.e., alleles), including APOE2, APOE3 and APOE4. Past studies have linked the presence of two APOE4 alleles to a higher risk of developing AD, while two APOE2 alleles were linked to a significantly lower risk of AD.

Researchers at the University of Kentucky and other institutes genetically engineered a type of mouse that carries a genetic “switch” that can be activated with a drug and that converts the harmful APOE4 allele into the protective APOE2 allele.

Hormone-disrupting chemicals from plastics shown to promote a chronic inflammatory skin condition

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.

The new findings about the disorder build on previous reports about the role of endocrine-disrupting chemicals, a common environmental contaminant known to mimic, block or alter the body’s hormones, in human health. Researchers believe their findings suggest that reducing exposure could ease HS symptom severity and provide a new avenue of relief for a disease with limited FDA-approved treatment options that include biologic therapy and surgery.

The full report on the study was published in Nature Communications on Nov. 28 and includes insights into the molecular mechanisms that are involved in the disease.

Artificial tendons give muscle-powered robots a boost

Our muscles are nature’s actuators. The sinewy tissue is what generates the forces that make our bodies move. In recent years, engineers have used real muscle tissue to actuate “biohybrid robots” made from both living tissue and synthetic parts. By pairing lab-grown muscles with synthetic skeletons, researchers are engineering a menagerie of muscle-powered crawlers, walkers, swimmers, and grippers.

But for the most part, these designs are limited in the amount of motion and power they can produce. Now, MIT engineers are aiming to give bio-bots a power lift with artificial tendons.

In a study published in the journal Advanced Science, the researchers developed artificial tendons made from tough and flexible hydrogel. They attached the rubber band-like tendons to either end of a small piece of lab-grown muscle, forming a “muscle-tendon unit.” Then they connected the ends of each artificial tendon to the fingers of a robotic gripper.

Samsung launches its first multi-folding phone as competition from Chinese brands intensifies

Samsung Electronics’s Galaxy Z TriFold media day at Samsung Gangnam in Seoul, South Korea, on Dec. 2, 2025.

Anadolu | anadolu | getty images.

Samsung Electronics on Monday announced the launch of its first multi-folding smartphone as it races to keep pace with innovations from fast-moving rivals.

Unexpected pathway for IgA antibody production may help improve vaccines

Scientists led by Stephanie Eisenbarth, MD, Ph.D., the Roy and Elaine Patterson Professor of Medicine and director of the Center for Human Immunobiology, have discovered how critical IgA antibodies are produced through unexpected cellular pathways, findings that may help inform the design of more effective vaccines to prevent infections, according to a recent study published in Immunity.

Immunoglobulin (Ig)A is an antibody that serves as the first line of defense for mucosal tissues that comprise the inner lining of organs in the respiratory system and digestive system. IgA antibodies play a role in humoral immunity, in which IgA and other antibodies produced by B-cells fight off and prevent the spread of infection.

However, inducing an IgA-specific immune response, particularly through vaccines, has remained unsuccessful, according to Eisenbarth.

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration

Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. Here we identify a FHR1-driven pathway fostering chronic cellular inflammation. FHR1 accumulates below the retinal pigment epithelium (RPE) in AMD donor tissue and similarly the murine homolog, muFHR1 is abundant in three AMD-relevant mouse models. These mouse models express the muFHR1 receptor EGF-like module-containing mucin-like hormone receptor 1 (Emr1) on the RPE and on invading mononuclear phagocytes (MP), where both cells form clusters via muFHR1/Emr1.

Evidence of rain-driven climate on Mars found in bleached rocks scattered in Jezero crater

Rocks that stood out as light-colored dots on the reddish-orange surface of Mars now are the latest evidence that areas of the small planet may have once supported wet oases with humid climates and heavy rainfall comparable to tropical climates on Earth.

The rocks discovered by NASA’s Perseverance Mars rover are white, aluminum-rich kaolinite clay, which forms on Earth after rocks and sediment are leached of all other minerals by millions of years of a wet, rainy climate.

These findings were published Monday (Dec. 1) in the journal Communications Earth & Environment by lead author Adrian Broz, a Purdue University postdoctoral research associate in the lab of Briony Horgan, a long-term planner on NASA’s Mars Perseverance rover mission and professor of planetary science in the Department of Earth, Atmospheric, and Planetary Sciences in Purdue’s College of Science.

Bipolar planetary nebula reveals rare open cluster association

By analyzing the data from the SuperCOSMOS Hα Survey (SHS) and from the Gaia satellite, astronomers have inspected a bipolar planetary nebula designated PHR J1724-3859. Results of the study, published Nov. 19 on the arXiv pre-print server, deliver crucial insights into the properties of this nebula.

Planetary nebulae (PNe) are the final stages of evolution of low-to-intermediate mass stars. They are expanding shells of gas and dust that have been ejected from a star during the process of its evolution from a main sequence star into a red giant or white dwarf. PNe are relatively rare, but important for astronomers studying the chemical evolution of stars and galaxies.

Detecting strong-to-weak symmetry breaking might be impossible, study shows

When a system undergoes a transformation, yet an underlying physical property remains unchanged, this property is referred to as “symmetry.” Spontaneous symmetry breaking (SSB) occurs when a system breaks out of this symmetry when it is most stable or in its lowest-possible energy state.

Recently, physicists realized that a new type of SSB can occur in open quantum systems, systems driven by quantum mechanical effects that can exchange information, energy or particles with their surrounding environment. Specifically, they realized that the symmetry in these systems can be “strong” or “weak.”

A strong symmetry entails that both the open system and its surrounding environment individually obey the symmetry. In contrast, a weak symmetry takes place when the system and the environment only follow a symmetry when they are taken together.

Why your faucet drips: Water jet breakup traced to angstrom-scale thermal capillary waves

Some phenomena in our daily lives are so commonplace that we don’t realize there could be some very interesting physics behind them. Take a dripping faucet: why does the continuous stream of water from a faucet eventually break up into individual droplets? A team of physicists studied this question and reached surprising conclusions.

The breakthrough in understanding how a water jet breaks up into droplets was made by a team consisting of Stefan Kooij, Daniel T. A. Jordan, Cees J. M. van Rijn, and Daniel Bonn from the University of Amsterdam (Van der Waals-Zeeman Institute / Institute of Physics), along with Neil M. Ribe from the Université Paris-Saclay. The study is published in the journal Physical Review Letters.

/* */