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New DNA-Based Therapy Can Help Lower ‘Bad Cholesterol’ Without Statins, Finds Study

Scientists may have found a powerful new way to lower “bad” cholesterol, which did not involve the use of statin medicines. In a recent study, researchers used tiny DNA-based molecules to cut levels of LDL (bad) cholesterol by nearly 50% in animal models. This was done without the side effects that are often linked to statins. If these results stay consistent in large human trials, the therapy could become an important option for people who cannot tolerate statins or who still have high cholesterol despite taking them. The study was led by Carles J. Ciudad and Veronica Noe from the University of Barcelona’s Faculty of Pharmacy and Food Sciences and the Institute of Nanoscience and Nanotechnology (IN2UB), working with Nathalie Pamir at the University of Oregon in Portland (United States). It was published in the journal Biochemical Pharmacology.

High LDL cholesterol is one of the biggest risk factors for heart attacks and strokes because it leads to the build up fatty plaques in arteries. Drugs like statins work well for many, but some people suffer from muscle aches, digestive issues, or liver problems and have to stop them. However, the new approach is different. Instead of changing how the liver handles fats, it targets a specific protein in the blood that controls how much LDL stays circulating.

It stands over 100 feet tall, is nearly 200 feet wide at the base, and may be older than many famous monuments; now NOAA believes that this Maug coral may hold clues to the future of reefs

NOAA measures a giant Mariana Islands megacoral that may be over 2,000 years old in a stunning undersea volcano setting.

Evolution isn’t random. Scientists find the same genes used for 120 million years

Evolution seems to follow a script more often than expected. Researchers found that distantly related butterflies and moths have reused the same pair of genes for over 120 million years to produce strikingly similar warning colors. Rather than altering the genes themselves, evolution modifies how they’re switched on and off. This discovery hints that life may evolve in more predictable ways than previously believed.

This laser turns metal into a star-like plasma in trillionths of a second

In a striking glimpse into extreme physics, scientists have captured the split-second chaos that unfolds when powerful laser flashes blast matter into a superheated plasma. By combining two cutting-edge lasers, researchers were able to track how copper atoms lose and regain electrons in trillionths of a second, creating and dissolving highly charged ions in a rapid, almost cinematic sequence.

Citraconate preserves T cell stemness and antitumor immunity

The metabolite citraconate can preserve T cell stemness and suppress exhaustion, promoting antitumor immunity and responses to immunotherapies in mice.

Learn more in Science Immunology.


Sci. Immunol. 11, eadz0348 (2026). DOI:10.1126/sciimmunol.adz0348

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