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Category: neuroscience – Page 85

Striking intelligence of Neanderthal stone knappers revealed

University of Wollongong researchers have experimentally confirmed that changes in hammer strike angle significantly affect the fracture path and form of stone flakes produced by Neanderthals during the Middle Paleolithic.

Published in Archaeological and Anthropological Sciences, the findings contradict a widely cited fracture model that credited rock core geometry and stiffness with flaking patterns and predicted that hammer strike angle would have minimal effect on flake formation. Results suggest a greater degree of cognitive control by early human tool makers than previously recognized.

Middle Paleolithic stone tool technology is defined by deliberate core preparation to produce flakes of predetermined size and shape. First appearing in the between 200,000 and 400,000 years ago, the Levallois method is a hallmark of Neanderthal tool making in this period.

Hidden network links may predict sudden shifts like seizures and climate tipping points

The global climate is in an imbalance. Potential “tipping elements” include the Greenland ice sheet, coral reefs, and the Amazon rainforest. Together they form a network that can collapse if just one individual component tips.

Researchers from Bonn University Hospital (UKB) and the University of Bonn have now shed light on seemingly sudden and rare, often irreversible changes within a system, such as those that can be observed in the climate, the economy, social networks or even the human brain. They took a closer look at extreme events such as epileptic seizures.

Their aim was to better understand the mechanisms underlying such changes in order to ultimately make predictions. The results of their work have now been published in the journal Physical Review Research.

Jamais vu: the science behind eerie opposite of déjà vu

Our research found that the phenomenon arises when the part of the brain which detects familiarity de-synchronises with reality. Déjà vu is the signal which alerts you to this weirdness: it is a type of “fact checking” for the memory system.

But repetition can do something even more uncanny and unusual. The opposite of déjà vu is “jamais vu”, when something you know to be familiar feels unreal or novel in some way. In our recent research, which has just won an Ig Nobel award for literature, we investigated the mechanism behind the phenomenon.

Jamais vu may involve looking at a familiar face and finding it suddenly unusual or unknown. Musicians have it momentarily – losing their way in a very familiar passage of music. You may have had it going to a familiar place and becoming disorientated or seeing it with “new eyes”

Sleep stages antagonistically modulate reactivation drift

Bollmann et al. track reactivated CA1 assemblies representing spatial memories during 16–20 h of sleep/rest. Assemblies initially reflect recently learned spatial memories but are gradually transformed into those seen during the memory recall session following rest. Whereas slow-wave sleep accelerates the assembly drift, REM epochs counteract it.

Brain networks rewire to compensate for difficulty hearing speech in noisy environments, study finds

As they age, some people find it harder to understand speech in noisy environments. Now, University at Buffalo researchers have identified the area in the brain, called the insula, that shows significant changes in people who struggle with speech in noise.

The findings, published in the journal Brain and Language, contribute to the growing link between hearing loss and leading to . Previous research has separately established connections between hearing difficulties and dementia, as well as insula abnormalities and cognitive decline.

The insulae are two complicated structures that interact with the brain’s frontal lobe, which is responsible for higher-level cognitive function. The insulae integrate sensory, emotional and cognitive information.

Contemplating art’s beauty found to boost abstract and ‘big picture’ thinking

Since the dawn of philosophy, thinkers from Plato to Kant have considered how beauty affects human experience, and whether it has the power to transform our state of mind.

Now, a new study from the University of Cambridge suggests that stopping to contemplate the beauty of artistic objects in a gallery or museum boosts our ability to think in abstract ways and consider the “bigger picture” when it comes to our lives.

Researchers say the findings offer that engaging with artistic beauty helps us escape the “mental trappings of daily life,” such as current anxieties and to-do lists, and induce “psychological distancing”: the process of zooming out on your thoughts to gain clarity.

Endogenous Opioids in Systems Neuroscience

Due to the prevalence of chronic pain worldwide, there is an urgent need to improve pain management strategies. While opioid drugs have long been used to treat chronic pain, their use is severely limited by adverse effects and abuse liability. Neurostimulation techniques have emerged as a promising option for chronic pain that is refractory to other treatments. While different neurostimulation strategies have been applied to many neural structures implicated in pain processing, there is variability in efficacy between patients, underscoring the need to optimize neurostimulation techniques for use in pain management. This optimization requires a deeper understanding of the mechanisms underlying neurostimulation-induced pain relief. Here, we discuss the most commonly used neurostimulation techniques for treating chronic pain. We present evidence that neurostimulation-induced analgesia is in part driven by the release of endogenous opioids and that this endogenous opioid release is a common endpoint between different methods of neurostimulation. Finally, we introduce technological and clinical innovations that are being explored to optimize neurostimulation techniques for the treatment of pain, including multidisciplinary efforts between neuroscience research and clinical treatment that may refine the efficacy of neurostimulation based on its underlying mechanisms.

Over 20% of people worldwide suffer from chronic pain disorders (Goldberg and McGee, 2011). In response to an unmet need for effective pain management, opioid drugs have been widely adopted. Opioid drugs harness the body’s endogenous opioid receptors, which are dispersed throughout the central and peripheral nervous system to modulate pain perception. While prescription opioids often provide effective pain relief, they have undesirable and potentially dangerous side effects including abuse liability and respiratory depression. Their contribution to the ongoing opioid epidemic and the enormous negative impact of chronic pain underscore the need for safe and effective pain therapies (Manchikanti et al., 2012). Neurostimulation therapies are potential alternatives for managing medically refractory pain. However, these therapies are hampered by inconsistent pain relief across patients and diminishing analgesic effects over time (Kumar K. et al., 1998).

Ancient Andes society used hallucinogens to strengthen social order, snuff tubes suggest

Two thousand years before the Inca empire dominated the Andes, a lesser-known society known as the Chavín Phenomenon shared common art, architecture, and materials throughout modern-day Peru. Through agricultural innovations, craft production, and trade, Chavín shaped a growing social order and laid the foundations for a hierarchical society among the high peaks.

But one of their most powerful tools wasn’t farming. It was access to altered states of consciousness.

That’s according to a new study that uncovered the earliest-known direct evidence of the use of psychoactive plants in the Peruvian Andes. A team of archaeologists from the University of Florida, Stanford University and South American institutions discovered ancient snuff tubes carved from hollow bones at the heart of monumental stone structures at Chavín de Huántar, a prehistoric ceremonial site in the mountains of Peru.

Glymphatics and meningeal lymphatics unlock the brain-immune code

Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an “immune code” that, when presented by meningeal antigen-presenting cells, instructs T cells to safeguard neural homeostasis. They review how inflammation, aging, and neurodegeneration disrupt this finely tuned process and highlight emerging therapeutic opportunities.

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