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Haven’t heard from Bill Andrews in awhile.


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Here we talk with Dr Bill Andrews all about telomeres, why they are on the critical path of aging and finding a way to lengthen them is required in an complete longevity solution.
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New research reveals that prolonged mental load weakens brain connectivity, but compensatory mechanisms keep cognitive performance steady.


Summary: A recent study shows that prolonged mental exertion weakens connectivity between the brain’s frontal and parietal lobes, impacting cognitive efficiency. However, the brain has built-in compensatory mechanisms that adjust neural connections to preserve function under fatigue.

Researchers observed this in participants completing memory tasks of varying difficulty; while fatigue slowed performance on simple tasks, complex tasks triggered compensatory adjustments. Findings suggest that these mechanisms allow the brain to optimize resources based on task complexity.

Understanding how these processes work can have implications for enhancing productivity and mental resilience in high-demand scenarios. This research highlights the brain’s adaptability in managing limited cognitive resources under strain.

UC Santa Barbara researchers discovered that single, vigorous exercise sessions, especially under 30 minutes, improve cognitive functions like memory and executive function. Future studies will explore whether combining physical activity with cognitive tasks yields even greater benefits.

Years of research on exercise have long supported the idea that consistent workouts over time lead to both physical and cognitive benefits. But what about short, intense bursts of exercise? A team of scientists at UC Santa Barbara has taken a closer look.

Their study was recently published in the journal Communications Psychology.

New research underscores the role of the immune system in depression, linking inflammation to poor response to standard antidepressants and highlighting the importance of personalized medicine in addressing different biological patterns in depressed individuals.

A collaborative study between researchers from the UK and Italy has uncovered new insights into the biological mechanisms of major depressive disorder (MDD), with a particular focus on the role of the immune system.

The researchers examined “gene expression,” which refers to the process by which the instructions in our genes are activated, influencing bodily functions.

Research reveals how antibodies affect brain receptors in patients with anti-NMDAR encephalitis, a condition often misdiagnosed as schizophrenia.

The disease, vividly described in Susannah Cahalan’s memoir “Brain on Fire,” can lead to severe neurological symptoms similar to those of mental health disorders. The study underscores the importance of personalized medicine and improved diagnostics to accurately treat and diagnose this rare disease.

The startling diagnosis of susannah cahalan.

Finding ways to connect the human body to technology could have broad applications in health and entertainment. A new “electric plastic” could make self-powered wearables, real-time neural interfaces, and medical implants that merge with our bodies a reality.

While there has been significant progress in the development of wearable and implantable technology in recent years, most electronic materials are hard, rigid, and feature toxic metals. A variety of approaches for creating “soft electronics” has emerged, but finding ones that are durable, power-efficient, and easy to manufacture is a significant challenge.

Organic ferroelectric materials are promising because they exhibit spontaneous polarization, which means they have a stable electric field pointing in a particular direction. This polarization can be flipped by applying an external electrical field, allowing them to function like a bit in a conventional computer.