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Category: neuroscience – Page 740

Dr. Antonio Giordano, MD, Ph.D. — President and Founder, Sbarro Health Research Organization

Integrated And Cross-Disciplinary Research Focused on Diagnosing, Treating And Curing Cancers — Dr. Antonio Giordano MD, PhD, President & Founder, Sbarro Health Research Organization.

Dr. Antonio Giordano, MD, Ph.D., (https://www.drantoniogiordano.com/) is President and Founder of the Sbarro Health Research Organization (https://www.shro.org/), which conducts research to diagnose, treat and cure cancer, but also has diversified into research beyond oncology, into the areas of cardiovascular disease, diabetes and other chronic illnesses.

Dr. Giordano is also a Professor of Molecular Biology at Temple University in Philadelphia, a ‘Chiara fama’ Professor in the Department of Pathology & Oncology at the University of Siena, Italy, and Director of the Sbarro Institute for Cancer Research and Molecular Medicine, and the Center for Biotechnology, at Temple’s College of Science & Technology.

In his research throughout the years, Dr. Giordano has identified numerous tumor suppressor genes, including Rb2/p130, which has been found to be active in lung, endometrial, brain, breast, liver and ovarian cancers, as well as interesting synergistic effects of gamma radiation in combination with this gene, accelerating the death of tumor cells.

Dr. Giordano went on to discover Cyclin A, Cdk9 (which is known to play critical roles in HIV transcriptions, inception of tumors, and cell differentiation), and Cdk10. Dr. Giordano also developed patented technologies for diagnosing cancer.

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A Common Infection Could Be a Trigger For Multiple Sclerosis, Large Study Finds

For most of the time since the first description of multiple sclerosis (MS) in 1,868 the causes of this disabling disease have remained uncertain. Genes have been identified as important, which is why having other family members with MS is associated with a greater risk of developing the disease.

A recent study my colleagues and I conducted found that several types of infection during the teenage years are associated with MS after age 20. Our study didn’t investigate whether people who are more likely to have genetic risks for MS were also more likely to have worse infections.

This might explain why people with MS also have more infections that need hospital treatment.

Not Science Fiction: German Scientists Harness the Power of Photosynthesis for New Way To “Breathe”

Photosynthesizing algae injected into the blood vessels of tadpoles supply oxygen to their brains.

Leading a double life in water and on land, frogs have many breathing techniques – through the gills, lungs, and skin – over the course of their lifetime. Now German scientists have developed another method that allows tadpoles to “breathe” by introducing algae into their bloodstream to supply oxygen. The method developed, presented October 13 in the journal iScience, provided enough oxygen to effectively rescue neurons in the brains of oxygen-deprived tadpoles.

“The algae actually produced so much oxygen that they could bring the nerve cells back to life, if you will,” says senior author Hans Straka of Ludwig-Maximilians-University Munich. “For many people, it sounds like science fiction, but after all, it’s just the right combination of biological schemes and biological principles.”

AI Can Detect Signals for Mental Health Assessment

AI can detect signals that are informative about mental health from questionnaires and brain scans.

A study published today by an interdisciplinary collaboration, directed by Denis Engemann from Inria, demonstrates that machine learning from large population cohorts can yield “proxy measures” for brain-related health issues without the need for a specialist’s assessment. The researchers took advantage of the UK Biobank, one of the world’s largest and most comprehensive biomedical databases, that contains detailed and secure health-related data on the UK population. This work is published in the open access journal GigaScience.

Mental health issues have been increasing worldwide, with the WHO determining that there has been a 13% increase in mental health conditions and substance abuse disorders between 2007 and 2017. The burden these diseases place on society is extensive, negatively impacting nearly every area of life: school, work, family, friends, and community engagement. Among the many issues impeding the ability of society to address these disorders is that diagnoses of such health issues requires specialists; the availability of which ranges drastically across the globe. The development of machine learning methodology for the purposes of facilitating mental-health assessments could provide a much needed additional means to help detect, prevent and treat such health issues.

Chocolate Intake Is Associated With Reduced All-Cause And Cause-Specific Mortality Risk

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Papers referenced in the video:
Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial.
https://pubmed.ncbi.nlm.nih.gov/34329196/

Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.
https://pubmed.ncbi.nlm.nih.gov/15755830/

Other RCTs for the effect of chocolate on health:
Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial.
https://pubmed.ncbi.nlm.nih.gov/31744119/

Habitual cocoa intake reduces arterial stiffness in postmenopausal women regardless of intake frequency: a randomized parallel-group study.
https://pubmed.ncbi.nlm.nih.gov/27881914/

High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A DoubleBlind Randomized Clinical Trial.

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US Army Funds ‘Sleeping Cap’ To Help Your Brain Clear Out Waste

We’ve all experienced brain fog and the drowsiness that comes with getting too little sleep. But what exactly happens in our brain during sleep that prepares us for another day in the morning? To understand how the brain disposes of so-called “metabolic waste”, teams of researchers are working on a study with $2.8 million funding from the U.S. Army who is looking to combat sleep disorders among the military. The scientists’ ultimate aim is to develop a “sleeping cap” that would analyze how fluids within the brain may be flushing out toxic, memory-impairing proteins while you sleep. The sleeping cap that the researchers aim to create would be lightweight and portable, with the ability to both track and stimulate the flow of the cerebrospinal fluid. In this way, the researchers hope to be able to treat sleeping disorders as they happen. all experienced brain fog and the drowsiness that comes with getting too little sleep. But what exactly happens in our brain during sleep that prepares us for another day in the morning? To understand how the brain disposes of so-called “metabolic waste”, teams of researchers are working on a study with a $2.8 million funding from the U.S. Army who is looking to combat sleep disorders among the military. The scientists’ ultimate aim is to develop a “sleeping cap” that would analyze how fluids within the brain may be flushing out toxic, memory-impairing proteins while you sleep.

Brain’s White Matter Integrity Disrupted in People With Alzheimer’s Gene Mutation

The structural integrity of the brain’s white matter as measured with an advanced MRI technique is lower in cognitively normal people who carry a genetic mutation associated with Alzheimer’s disease than it is in non-carriers, according to a study in Radiology. Researchers said the findings show the promise of widely available imaging techniques in helping to understand early structural changes in the brain before symptoms of dementia become apparent.

People who carry the autosomal dominant Alzheimer disease (ADAD) mutation have a higher risk of Alzheimer’s disease, a type of dementia that affects about one in nine people in the United States. The mutation is linked to a buildup of abnormal protein called amyloid-beta in the brain that affects both the gray matter and the signal-carrying white matter.

“It’s thought that the amyloid deposition in the gray matter could disrupt its function, and as a result the white matter won’t function correctly or could even atrophy,” said study lead author Jeffrey W. Prescott, M.D., Ph.D., neuroradiologist at the MetroHealth Medical Center in Cleveland.

Oxytocin does not improve social functioning in children with autism spectrum disorder, NIH-funded study suggests

Findings from study believed to be largest of its kind contradict smaller studies showing treatment’s promise.

Regular doses of the hormone oxytocin do not appear to overcome deficits in social functioning among children with autism spectrum disorder (ASD), suggests a study funded by the National Institutes of Health. The findings contradict earlier reports that indicated the hormone could alleviate the difficulties in social functioning characteristic of ASD. Oxytocin is associated with empathy and social bonding. The study was conducted by Linmarie Sikich, M.D., of Duke University, and colleagues. It appears in the New England Journal of Medicine.

Funding was provided by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and National Center for Advancing Translational Sciences.

Migraines Caused by Alterations in Metabolite Levels

“Lower levels of DHA are associated with inflammation, cardiovascular and brain disorders, such as depression, which are all linked to migraine risk.”

Professor Nyholt said LPE(20:4) was a chemical compound that blocked the production of an anti-inflammatory molecule called anandamide.

Summary: Researchers have identified causal genetic links to three blood metabolite levels that increase migraine risks.

Source: Queensland University of Technology

Migraines are a pain in the head and in the hip pocket, but newly discovered genetic causes by QUT researchers could lead the way to new preventative drugs and therapies.

Genetic analyses findings were published in The American Journal of Human Genetics by Professor Dale Nyholt and his PhD candidates Hamzeh Tanha and Anita Sathyanarayanan, all from the QUT Centre for Genomics and Personalised Health.

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