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Category: neuroscience – Page 739

Consuming a single dose of the psychedelic brew ayahuasca can result in lasting changes in higher-order cognitive brain networks, according to a new study published in the Journal of Psychopharmacology.

Ayahuasca, a concoction used for centuries by indigenous Amazon tribes, contains the powerful psychedelic drug dimethyltryptamine (DMT) and monoamine oxidase inhibitors. The brew is typically prepared using leaves from the Psychotria viridis shrub and the bark of the Banisteriopsis caapi vine.

The new neuroimaging research suggests that ayahuasca may produce long-lasting effects on mood by altering the functional connectivity of the brain’s salience and default mode networks.

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With these new findings scientists can potentially better understand the subtle changes that can occur in genes and brain circuits that can lead to mental health disorders such as anxiety and autism spectrum disorders.

Although physically very different, research has found that the brains of flies, mice and humans are similar in how they form and how they function. Data has shown that the that underlie the brain development of insects and mammals are very similar but this can be interpreted in two different ways, where some believe it provides evidence of one single ancestor for both mammals and insects and others think it could support the theory that brains evolved multiple times independently.

Published in the journal Proceedings of the National Academy of Sciences (PNAS), this collaborative study between King’s College London, University of Arizona, University of Leuven and Leibniz Institute DSMZ has provided strong evidence that the mechanisms that regulate genetic activity required for the formation of brain areas important to control behavior, is the same for insects and mammals.

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Our brains have an upper limit on how much they can process at once due to a constant but limited energy supply, according to a new UCL study using a brain imaging method that measures cellular metabolism.

The study, published in the Journal of Neuroscience, found that paying attention can change how the brain allocates its limited energy; as the brain uses more energy in processing what we attend to, less energy is supplied to processing outside our attention focus.

Explaining the research, senior author Professor Nilli Lavie (UCL Institute of Cognitive Neuroscience) said: It takes a lot of energy to run the human brain. We know that the brain constantly uses around 20% of our metabolic energy, even while we rest our mind, and yet it’s widely believed that this constant but limited supply of energy does not increase when there is more for our mind to process.

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SAN CARLOS, Calif., Feb. 19, 2020 /PRNewswire/ — ZAP Surgical Systems, Inc. today announced an agreement with Bonifatius Hospital in Lingen, Germany to acquire ZAP-X® stereotactic radiosurgery (SRS) technology.

SRS is a well-known and effective procedure for non-invasively treating select brain tumors and brain metastases. However, significant acquisition and radiation shielding costs of historical SRS systems have limited widespread access to this potentially life-saving therapy. Consequently, scarce availability of SRS treatment has remained heavily concentrated in large urban hospitals.

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Summary: Repetitive transcranial memory stimulation applied to the dorsolateral prefrontal cortex modifies the negative effects of fear memories. The findings could have implications for the treatment of PTSD.

Source: University of Bologna

A research group from the University of Bologna has succeeded in modifying the negative effect of a returning memory that triggers fear, and developed a new non-invasive experimental protocol. The result of this study, published in the journal Current Biology, is an innovative protocol that combines fear conditioning—a stimulus associated with something unpleasant that induces a negative memory—and the neurostimulation of a specific site of the prefrontal cortex.

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When we say someone has a quick mind, it may be in part thanks to our expanded cerebellum that distinguishes human brains from those of macaque monkeys, for example.

Sometimes referred to by its Latin translation as the ‘“little brain”’, the is located close to the brainstem and sits under the in the hindbrain. New research at San Diego State University, however, calls the “little” terminology into question.

The cerebellum plays a versatile role, contributing to our five senses as well as pain, movements, thought, and emotion.

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Summary: Activating p38gamma, a naturally protective enzyme in the brain, may help to prevent the development of Alzheimer’s disease symptoms. Researchers showed the naturally protective effects of p38gamma could be harnessed to improve memory in the later stages of Alzheimer’s disease.

Source: Macquarie University

A ground-breaking new treatment developed by Macquarie University scientists has reversed the effects of memory loss associated with Alzheimer’s disease in a study of mice with advanced dementia.

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Summary: Researchers successfully applied a gene therapy platform to completely correct brain defects in a large animal model of a human genetic disease.

Source: University of Pennsylvania

A lone genetic mutation can cause a life-changing disorder with effects on multiple body systems. Lysosomal storage diseases, for example, of which there are dozens, arise due to single mutations that affect production of critical enzymes required to metabolize large molecules in cells. These disorders affect multiple organs including, notably, the brain, causing intellectual disability of varying degrees.

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The discovery could lead to long lasting brain implants that can both treat neurological disease and enable mind controlled prosthetics and machines.

A group of researchers from the University of Michigan has created a new ultra-low-power brain implant. The scientists say that the estimated reduction in power requirements is about 90% for their new creations. Not only have they reduced the power requirements for the implants, they have also made them more accurate.

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