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Category: neuroscience – Page 636

Mechanism of gene mutations linked to autism, Alzheimer’s found by TAU

A mechanism that causes autism, schizophrenia, Alzheimer’s and other conditions and is shared by mutations in the genes ADNP and SHANK3 has been unraveled by Tel Aviv University researchers who developed an experimental drug they found to be effective in animal models.

The drug could also be suitable for treating a range of rare syndromes that impair brain functions, said the scientists. The researchers were led by Prof. Illana Gozes from the Department of Human Molecular Genetics and Biochemistry at TAU’s Sackler Faculty of Medicine and the Sagol School of Neuroscience. The experimental drug, called Davunetide, had previously been developed in her lab.

The paper, which the team called a “scientific breakthrough,” was published in the scientific journal Molecular Psychiatry under the title “SH3-and actin-binding domains connect ADNP and SHANK3, revealing a fundamental shared mechanism underlying autism.”

Scientific breakthrough cures memory loss in mice

Researchers at Stanford University are reversing symptoms of Alzheimer’s in mice using a strange tactic — they’re infusing elderly mice with spinal fluid from younger ones.

Many medical breakthroughs that benefit humans are discovered by conducting trials on mice.

Though we look nothing alike, almost all the genes found in mice have similar functions to genes in humans. We get diseases for the same reasons, meaning scientists can study illnesses closely in mice to understand how they manifest in us.

One disease that has evaded scientists for decades is Alzheimer’s. Its commonality increases with age, affecting 1 in 14 people over the age of 65. But early onset Alzheimer’s is prevalent too and 1 in 20 people with the disease are below the age of 65.

JUST IN! Elon Musk & NASA’s New Light Speed Engine DEFIES Laws Of PHYSICS!

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You’d be instantly where you want to be if you moved at the speed of light. Indeed, light-speed travel has been a fantasy of many scientists and aerospace engineers who look for ways to achieve it.
And now, it seems Elon Musk and NASA have broken that fantasy code to build a light-speed engine that defies the laws of physics.

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The evolution and development of consciousness: the subject-object emergence hypothesis

A strategy for investigating consciousness that has proven very productive has focused on comparing brain processes that are accompanied by consciousness with processes that are not. But comparatively little attention has been given to a related strategy that promises to be even more fertile. This strategy exploits the fact that as individuals develop, new classes of brain processes can transition from operating ‘in the dark’ to becoming conscious. It has been suggested that these transitions occur when a new class of brain processes becomes object to a new, emergent, higher-level subject. Similar transitions are likely to have occurred during evolution. An evolutionary/developmental research strategy sets out to identify the nature of the transitions in brain processes that shift them from operating in the dark to ‘lighting up’. The paper begins the application of this strategy by extrapolating the sequence of transitions back towards its origin. The goal is to reconstruct a minimally-complex, subject-object subsystem that would be capable of giving rise to consciousness and providing adaptive benefits. By focusing on reconstructing a subsystem that is simple and understandable, this approach avoids the homunculus fallacy. The reconstruction suggests that the emergence of such a minimally-complex subsystem was driven by its capacity to coordinate body-environment interactions in real time e.g. hand-eye coordination. Conscious processing emerged initially because of its central role in organising real-time sensorimotor coordination. The paper goes on to identify and examine a number of subsequent major transitions in consciousness, including the emergence of capacities for conscious mental modelling. Each transition is driven by its potential to solve adaptive challenges that cannot be overcome at lower levels. The paper argues that mental modelling arose out of a pre-existing capacity to use simulations of motor actions to anticipate the consequences of the actions. As the capacity developed, elements of the simulations could be changed, and the consequences of these changes could be ‘thought through’ consciously. This enabled alternative motor responses to be evaluated. The paper goes on to predict significant new major transitions in consciousness.

SciShots: A quartet of brain cells

Allen Institute neuroscientist JoAnn Buchanan and team are studying the interaction between two kinds of non neuronal brain cells, a microglia (shown in purple)… See more.

Scientists are sifting through the hundreds of thousands of brain cells present in a cubic millimeter of mouse brain.

How the Brain ‘Constructs’ the Outside World

Like other young researchers, I began my investigation of the brain without worrying much whether this perception-action theoretical framework was right or wrong. I was happy for many years with my own progress and the spectacular discoveries that gradually evolved into what became known in the 1960s as the field of “neuroscience.” Yet my inability to give satisfactory answers to the legitimate questions of my smartest students has haunted me ever since. I had to wrestle with the difficulty of trying to explain something that I didn’t really understand.

Over the years I realized that this frustration was not uniquely my own. Many of my colleagues, whether they admitted it or not, felt the same way. There was a bright side, though, because these frustrations energized my career. They nudged me over the years to develop a perspective that provides an alternative description of how the brain interacts with the outside world.

The challenge for me and other neuroscientists involves the weighty question of what, exactly, is the mind. Ever since the time of Aristotle, thinkers have assumed that the soul or the mind is initially a blank slate, a tabula rasa on which experiences are painted. This view has influenced thinking in Christian and Persian philosophies, British empiricism and Marxist doctrine. In the past century it has also permeated psychology and cognitive science. This “outside-in” view portrays the mind as a tool for learning about the true nature of the world. The alternative view—one that has defined my research—asserts that the primary preoccupation of brain networks is to maintain their own internal dynamics and perpetually generate myriad nonsensical patterns of neural activity. When a seemingly random action offers a benefit to the organism’s survival, the neuronal pattern leading to that action gains meaning. When an infant utters “te-te,” the parent happily offers the baby “Teddy,” so the sound “te-te” acquires the meaning of the Teddy bear. Recent progress in neuroscience has lent support to this framework.

“Off the Shelf” Engineered Stem Cells Created To Treat Aggressive Brain Cancer

Investigators uncovered a diagnostic method to identify receptors on cancer cells in the blood, then engineered a cell-based therapy to target and kill tumor cells in the brain, paving the way to clinical testing.

Glioblastomas (GBMs) are highly aggressive cancerous tumors of the brain and spinal cord. Brain cancers like GBM are challenging to treat because many cancer therapeutics cannot pass through the blood-brain barrier, and more than 90% of GBM tumors return after being surgically removed, despite surgery and subsequent chemo-and radiation therapy being the most successful way to treat the disease. In a new study led by investigators at Brigham and Women’s Hospital and Harvard Medical School, scientists devised a novel therapeutic strategy for treating GBMs post-surgery by using stem cells taken from healthy donors engineered to attack GBM-specific tumor cells. This strategy demonstrated profound efficacy in preclinical models of GBM, with 100 percent of mice living over 90 days after treatment. Results will be published today (May 19, 2022) in the journal Nature Communications.

“This is the first study to our knowledge that identifies target receptors on tumor cells prior to initiating therapy, and using biodegradable, gel-encapsulated, ‘off-the-shelf’ engineered stem cell based therapy after GBM tumor surgery,” said Khalid Shah, MS, PhD, director of the Center for Stem Cell and Translational Immunotherapy (CSTI) and the vice chair of research in the Department of Neurosurgery at the Brigham and faculty at Harvard Medical School and Harvard Stem Cell Institute (HSCI).