Robert Sapolsky’s book is now available for pre-order!
𝙊𝙣𝙚 𝙤𝙛 𝙤𝙪𝙧 𝙜𝙧𝙚𝙖𝙩 𝙗𝙚𝙝𝙖𝙫𝙞𝙤𝙧𝙖𝙡 𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩𝙨, 𝙩𝙝𝙚 𝙗𝙚𝙨𝙩𝙨𝙚𝙡𝙡𝙞𝙣𝙜 𝙖𝙪𝙩𝙝𝙤𝙧 𝙤𝙛 𝘽𝙚𝙝𝙖𝙫𝙚, 𝙥𝙡𝙪𝙢𝙗𝙨 𝙩𝙝𝙚 𝙙𝙚𝙥𝙩𝙝𝙨 𝙤𝙛 𝙩𝙝𝙚 𝙨𝙘𝙞𝙚𝙣𝙘𝙚 𝙖𝙣𝙙 𝙥𝙝𝙞𝙡𝙤𝙨𝙤𝙥𝙝𝙮 𝙤𝙛 𝙙𝙚𝙘𝙞𝙨𝙞𝙤𝙣-𝙢𝙖𝙠𝙞𝙣𝙜 𝙩𝙤 𝙢𝙤𝙪𝙣𝙩 𝙖 𝙙𝙚𝙫𝙖𝙨𝙩𝙖𝙩𝙞𝙣𝙜 𝙘𝙖𝙨𝙚 𝙖𝙜𝙖𝙞𝙣𝙨𝙩 𝙛𝙧𝙚𝙚 𝙬𝙞𝙡𝙡, 𝙖𝙣 𝙖𝙧𝙜𝙪𝙢𝙚𝙣𝙩 𝙬𝙞𝙩𝙝 𝙥𝙧𝙤𝙛𝙤𝙪𝙣𝙙 𝙘𝙤𝙣𝙨𝙚𝙦𝙪𝙚𝙣𝙘𝙚𝙨.
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The man himself:
Blueprint is a public science experiment to determine whether it’s possible to stay the same biological age. This requires slowing down aging processes as much as possible and then reversing the aging that has happened. Currently my speed of aging is .76 (DunedinPACE). That means for every 365 days each year, I age 277 days. My goal is to remain the same age biologically for every 365 days that pass.
I openly share (for free!) my diet, exercise and other protocols so that others can benefit and try to improve upon what I’m doing. I also openly share my health data as data is better than human opinion at guiding decision making. You can find everything here: https://blueprint.bryanjohnson.co/
This video is a whirlwind tour of what my daily life looks like as my team and I are on this adventure.
On the surface, Blueprint may seem like something about health, wellness and aging. To me, it’s a philosophy.
With some careful twisting and stacking, MIT physicists have revealed a new and exotic property in “magic-angle” graphene: superconductivity that can be turned on and off with an electric pulse, much like a light switch.
The discovery could lead to ultrafast, energy-efficient superconducting transistors for neuromorphic devices—electronics designed to operate in a way similar to the rapid on/off firing of neurons in the human brain.
Magic-angle graphene refers to a very particular stacking of graphene—an atom-thin material made from carbon atoms that are linked in a hexagonal pattern resembling chicken wire. When one sheet of graphene is stacked atop a second sheet at a precise “magic” angle, the twisted structure creates a slightly offset “moiré” pattern, or superlattice, that is able to support a host of surprising electronic behaviors.
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Science fiction loves to show us disembodied heads or brains floating in jars, but could this be one route to extending our lives? Or could you already be one living in false reality?
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Credits:
Life as a Brain in a Jar.
Episode 246; July 9, 2020
Written, produced & narrated by isaac arthur.
Editors.
Cancer vaccines are an active area of research for many labs, but the approach that Shah and his colleagues have taken is distinct. Instead of using inactivated tumor cells, the team repurposes living tumor cells, which possess an unusual feature. Like homing pigeons returning to roost, living tumor cells will travel long distances across the brain to return to the site of their fellow tumor cells. Taking advantage of this unique property, Shah’s team engineered living tumor cells using the gene editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agents. In addition, the engineered tumor cells were designed to express factors that would make them easy for the immune system to spot, tag, and remember, priming the immune system for a long-term anti-tumor response.
The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTC) in different mice strains, including the one that bore bone marrow, liver, and thymus cells derived from humans, mimicking the human immune microenvironment. Shah’s team also built a two-layered safety switch into the cancer cell, which, when activated, eradicates ThTCs if needed. This dual-action cell therapy was safe, applicable, and efficacious in these models, suggesting a roadmap toward therapy. While further testing and development is needed, Shah’s team specifically chose this model and used human cells to smooth the path of translating their findings for patient settings.
We speak at a rate of roughly 160 words every minute. That speed is incredibly difficult to achieve for speech brain implants.
Decades in the making, speech implants use tiny electrode arrays inserted into the brain to measure neural activity, with the goal of transforming thoughts into text or sound. They’re invaluable for people who lose their ability to speak due to paralysis, disease, or other injuries. But they’re also incredibly slow, slashing word count per minute nearly ten-fold. Like a slow-loading web page or audio file, the delay can get frustrating for everyday conversations.
A team led by Drs. Krishna Shenoy and Jaimie Henderson at Stanford University is closing that speed gap.
Summary: Tuning into a person’s brain wave cycle before they perform a learning task can dramatically improve the speed at which cognitive skills improve.
Source: University of Cambridge.
Scientists have shown for the first time that briefly tuning into a person’s individual brainwave cycle before they perform a learning task dramatically boosts the speed at which cognitive skills improve.
A recent study from researchers at the University of California, Irvine found that the removal of cilia from the striatum region of the brain negatively impacted time perception and judgement, opening the possibility for new therapeutic targets for mental and neurological conditions such as schizophrenia, Parkinson’s and Huntington’s diseases, autism spectrum disorder.
Autism Spectrum Disorder (ASD) is a complex developmental disorder that affects how a person communicates and interacts with others. It is characterized by difficulty with social communication and interaction, as well as repetitive behaviors and interests. ASD can range from mild to severe, and individuals with ASD may have a wide range of abilities and challenges. It is a spectrum disorder because the symptoms and characteristics of ASD can vary widely from person to person. Some people with ASD are highly skilled in certain areas, such as music or math, while others may have significant learning disabilities.
Year 2022 😗
Experts believe it is destined to become the world’s fifth major cancer treatment after surgery, chemotherapy, radiotherapy and immunotherapy.
The light-activated therapy forces cancer cells to glow in the dark, helping surgeons remove more of the tumours compared with existing techniques – and then kills off remaining cells within minutes once the surgery is complete. In a world-first trial in mice with glioblastoma, one of the most common and aggressive types of brain cancer, scans revealed the novel treatment lit up even the tiniest cancer cells to help surgeons remove them – and then wiped out those left over.
Trials of the new form of photoimmunotherapy, led by the Institute of Cancer Research, London, also showed the treatment triggered an immune response that could prime the immune system to target cancer cells in future, suggesting it could prevent glioblastoma coming back after surgery. Researchers are now also studying the new treatment for the childhood cancer neuroblastoma.