Lifeboat Foundation

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The researchers expect to test the findings in a clinical trial evaluating the stem cell therapy in newborns who experience a brain injury during birth called perinatal hypoxic-ischemic brain injury (HII). The study was published in Cell Reports.

“In order for stem cell therapies to benefit patients, we need to be thoughtful and scientific about who receives these treatments,” says Evan Y. Snyder, M.D., Ph.D., professor and director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys, and corresponding study author. “I am hopeful that MRI, which is already used during the course of care for these newborns, will help ensure that infants who experience HII get the best, most appropriate treatment possible. In the future, MRI could help guide the use of stem cells to treat—or in some instances, not treat—additional brain disorders such as spinal cord injury and stroke.”

Scientists now understand that, in many instances, human neural stem cells are therapeutic because they can protect living cells—in contrast to “re-animating” or replacing nerve cells that are already dead. As a result, understanding the health of brain tissue prior to a stem cell transplant is critical to the treatment’s potential success. Tools that help predict the efficacy of neural stem cell therapy could increase the success of clinical trials, which are ongoing in people with Parkinson’s disease, spinal cord injury and additional neurological conditions, while also sparing people who will not respond to treatment from an invasive procedure that offers false hope.

The team saw some early successes regarding movement — the initial goal of the BCI — allowing Burkhart to press buttons along the neck of a “Guitar Hero” controller.

But returning touch to his hand was a much more daunting task. By using a simple vibration device or “wearable haptic system,” Burkhart was able to tell if he was touching an object or not without seeing it.

“It’s definitely strange,” Burkhart told Wired. “It’s still not normal, but it’s definitely much better than not having any sensory information going back to my body.”

Are you taking any pills to enhance performance?

When it comes to the mind, there are a host of drugs that have become popular in various settings as nootropics, from college campuses to high power startups in Silicon Valley. Of these, a few families of drugs have accumulated a collection of research studies suggesting that they could be utilized safety, and also produce a desired effect.

The first such category of such drugs that performance enhancement seekers often try are stimulants. Two common such drugs are methylphenidate and dexamphetamine, which are used routinely and safely to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Despite their popularity for off-label use to boost concentration, however, these drugs are not really nootropics. They are actually quite dangerous if you don’t have ADHD or narcolepsy, or some other deficit, because tolerance builds up quickly, leading to dependence. Thus, while methylphenidate can keep you awake overnight or give you a boost in the morning, and possibly move you faster through a pile of non-creative work, they don’t really make you think better, and if you keep taking them you will be back to square one on performance, and with a drug dependence problem. You’d be better off with a strong cup of coffee.

Continue reading “Supercharged brains and the quest to think better and faster” »

Neuroplasticity is the brain’s ability to change under the influence of experience and activities. Several aspects of neuroplasticity are noteworthy: neurogenesis (development of new nerve cells) and synaptogenesis (development of new contacts between nerve cells) among them. Neuroplasticity used to be thought of as a limited phenomenon, mostly restricted to the early years of life. More recently it has been demonstrated that neuroplasticity continues throughout life, even in advanced age. This provides the conceptual basis for a wide range of therapeutic efforts aiming to slow the detrimental effects of aging on the brain and to treat various brain disorders.

What are the factors influencing neuroplasticity? The question is compelling both as a scientific challenge and because of the therapeutic promise of neuroplasticity once we know how to control and harness it. Among such factors, the environmental factors influencing neuroplasticity are particularly intriguing. It turns out that a strong relationship exists between what people do with their brains and how their brains age.

Both anecdotal observations and formal research suggest that education confers a protective effect against dementia. Highly educated people are less likely to succumb to its effects. Robert Katzman was the first to note that the prevalence of dementia, including Alzheimer’s disease, is lower in people with advanced education. The MacArthur Foundation Research Network on Successful Aging sponsored a study of the predictors of cognitive change in older persons. Education emerged as by far the most powerful predictor of cognitive vigor in old age.

Philippines on alert this week as Tropical Depression Ambo threatens the region with downpours and gusty winds.

(CNN) — Scientists have long known our brains need sleep to review the day’s events and transfer them into longer-term memories. Students are often told to study just before turning in to maximize their recall of material for a test the next day.

But the exact way in which the brain stores our memories is poorly understood.

Now for the first time, tiny microelectrodes planted inside the brains of two people show just how the brain’s neurons fire during sleep to “replay” our short-term memories in order to move them into more permanent storage. The study was published Tuesday in the journal Cell Reports.

While a person sleeps, the brain activates a crucial process called “offline replay.” This helps store new memories without overwriting the old.

We repurposed some tools from the Stem Cell Therapy for Cancer/Brain Tumor. Those tools are T-Cells, B-Cells, and Natural Killer Cells. Instead of programming those cancer killing cells to attack cancer cells, we have programmed them to seek out, identify, attack, and destroy all the Coronavirus cells in the entire body.

Stem Cell Neurotherapy sends therapeutic messages, e.g., “your stem cells are transforming into new cells for the lungs, liver, and kidneys” to the DNA inside the nucleus of stem cells. Inside the nucleus, the DNA receives the message and transmits it to the RNA, which translates the message into genetic code.

The genes inside the stem cells transmit the coded message to the proteins, which are converted by the mitochondria into ATP, which provides the energy for the coded message to transform the stem cells into a new set of lung cells, as well as new cells for the kidneys and liver.

Scientists in Hong Kong recently completed a clinical study in which they found that administering a cocktail of three different anti-viral medications to patients enduring mild coronavirus symptoms “may rapidly suppress the amount of virus in a patient’s body.”

The three-drug anti-viral cocktail is made up of the HIV medication lopinavir-ritonavir, the hepatitis therapy drug ribavirin and the multiple sclerosis treatment interferon-beta.