Lifeboat Foundation

Do we make conscious decisions? Or are all of our actions predetermined? And if we don’t have free will, are we responsible for what we do? Modern neurotechnology is now allowing scientists to study brain activity neuron by neuron to try to determine how and when our brains decide to act. In this program, experts probe the latest research and explore the question of just how much agency we have in the world, and how the answer impacts our ethics, our behavior, and our society.

This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation.

Continue reading “The Question of Free Will” »

Transhumanism is the idea that technology and evidence-based science can and should be used to augment and improve humans in order to overcome the limitations that evolution has left us with. As the name suggests, it stems from humanism, but it adds an optimism that cognitive and physical improvement is both possible and desirable.

On the face of it, the idea that humans should be permitted to use technology to live healthier and happier lives does not sound dangerous, or even contentious. But it does provoke strong opposition: in 2004, Francis Fukuyama called transhumanism “the world’s most dangerous idea”. The force of that claim is somewhat undermined when you consider how wildly wrong his previous big idea turned out to be: in 1992 he declared that because the Cold War ended with the collapse of the Soviet Union, history had come to an end. Nevertheless, Fukuyama is not alone in fearing transhumanism.

Some people object to transhumanism because they think we should strive to be “natural”, and to be content with what evolution – or their god — have given us. But of course the definition of what is “natural” changes over time. Nature didn’t endow us with spectacles, and few people now argue they should be banned. Now we have cochlear implants, and many people feel that their smartphones are extensions of themselves. In the future we will have the option of raising our IQ with smart drugs or with gene therapy, and these will be hotly debated.

Nerve cells require vast amounts of energy and oxygen which they receive through the bloodstream. This results in nerve tissue being densely intertwined with numerous blood vessels. However, what prevents neurons and vascular cells from interfering with each other during growth? Researchers from the Universities of Heidelberg and Bonn, in collaboration with international partners, have uncovered a mechanism that ensures this coordination. The findings have recently been published in the journal Neuron.

Nerve cells are highly energy-intensive, requiring a large amount of fuel. Approximately 20% of the calories we consume through food are dedicated to our brain, as the generation of voltage pulses (action potentials) and transmission between neurons is incredibly energy-demanding. For this reason, nerve tissue is usually crisscrossed by numerous blood vessels. They ensure a supply of nutrients and oxygen.

During embryonic development, a large number of vessels sprout in the brain and spinal cord, but also in the retina of the eye. Additionally, masses of neurons are formed there, which network with each other and with structures such as muscles and organs. Both processes have to be considerate of each other so as not to get in each other’s way. “We have identified a new mechanism that ensures this,” explains Prof. Dr. Carmen Ruiz de Almodóvar, member of the Cluster of Excellence ImmunoSensation2 and the Transdisciplinary Research Area Life & Health at the University of Bonn.

Neuroscientists have successfully increased the motivation to exert mental effort by using a weak alternating electrical current sent through electrodes attached to the scalp to synchronize brain waves. The findings, published in Cognitive, Affective, & Behavioral Neuroscience, help to identify the neural mechanisms underlying the willingness to engage in mental effort, suggesting that midfrontal theta oscillations play a key role.

“For a long time research has mainly focussed on which brain mechanisms underlie mental processes, but in the recent years it has become clear that engaging in mental activities needs to be understood as an active decision process where humans are willing to perform demanding mental tasks only if they are ‘worth it.’ The goal of our research was to get a better understanding of the brain mechanisms causally determining our motivation to engage in demanding mental activities,” explained study author Alexander Soutschek, a research group leader at the psychology department of the University of Munich.

For their study, the researchers utilized transcranial alternating current stimulation (tACS), a non-invasive neurostimulation technique that applies low-amplitude electrical current to the scalp through electrodes. The current modulates the neural activity in the brain regions under the electrodes, potentially enhancing or suppressing specific cognitive processes.

Robert Sapolsky’s book is now available for pre-order!

𝙊𝙣𝙚 𝙤𝙛 𝙤𝙪𝙧 𝙜𝙧𝙚𝙖𝙩 𝙗𝙚𝙝𝙖𝙫𝙞𝙤𝙧𝙖𝙡 𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩𝙨, 𝙩𝙝𝙚 𝙗𝙚𝙨𝙩𝙨𝙚𝙡𝙡𝙞𝙣𝙜 𝙖𝙪𝙩𝙝𝙤𝙧 𝙤𝙛 𝘽𝙚𝙝𝙖𝙫𝙚, 𝙥𝙡𝙪𝙢𝙗𝙨 𝙩𝙝𝙚 𝙙𝙚𝙥𝙩𝙝𝙨 𝙤𝙛 𝙩𝙝𝙚 𝙨𝙘𝙞𝙚𝙣𝙘𝙚 𝙖𝙣𝙙 𝙥𝙝𝙞𝙡𝙤𝙨𝙤𝙥𝙝𝙮 𝙤𝙛 𝙙𝙚𝙘𝙞𝙨𝙞𝙤𝙣-𝙢𝙖𝙠𝙞𝙣𝙜 𝙩𝙤 𝙢𝙤𝙪𝙣𝙩 𝙖 𝙙𝙚𝙫𝙖𝙨𝙩𝙖𝙩𝙞𝙣𝙜 𝙘𝙖𝙨𝙚 𝙖𝙜𝙖𝙞𝙣𝙨𝙩 𝙛𝙧𝙚𝙚 𝙬𝙞𝙡𝙡, 𝙖𝙣 𝙖𝙧𝙜𝙪𝙢𝙚𝙣𝙩 𝙬𝙞𝙩𝙝 𝙥𝙧𝙤𝙛𝙤𝙪𝙣𝙙 𝙘𝙤𝙣𝙨𝙚𝙦𝙪𝙚𝙣𝙘𝙚𝙨.

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Continue reading “Robert M. Sapolsky” »

The man himself:

Blueprint is a public science experiment to determine whether it’s possible to stay the same biological age. This requires slowing down aging processes as much as possible and then reversing the aging that has happened. Currently my speed of aging is .76 (DunedinPACE). That means for every 365 days each year, I age 277 days. My goal is to remain the same age biologically for every 365 days that pass.

Continue reading “Why I Am Spending Millions To Be 18 Again” »

With some careful twisting and stacking, MIT physicists have revealed a new and exotic property in “magic-angle” graphene: superconductivity that can be turned on and off with an electric pulse, much like a light switch.

The discovery could lead to ultrafast, energy-efficient superconducting transistors for neuromorphic devices—electronics designed to operate in a way similar to the rapid on/off firing of neurons in the human brain.

Magic-angle graphene refers to a very particular stacking of graphene—an atom-thin material made from carbon atoms that are linked in a hexagonal pattern resembling chicken wire. When one sheet of graphene is stacked atop a second sheet at a precise “magic” angle, the twisted structure creates a slightly offset “moiré” pattern, or superlattice, that is able to support a host of surprising electronic behaviors.

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Science fiction loves to show us disembodied heads or brains floating in jars, but could this be one route to extending our lives? Or could you already be one living in false reality?

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Continue reading “Life as a Brain in a Jar” »

Cancer vaccines are an active area of research for many labs, but the approach that Shah and his colleagues have taken is distinct. Instead of using inactivated tumor cells, the team repurposes living tumor cells, which possess an unusual feature. Like homing pigeons returning to roost, living tumor cells will travel long distances across the brain to return to the site of their fellow tumor cells. Taking advantage of this unique property, Shah’s team engineered living tumor cells using the gene editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agents. In addition, the engineered tumor cells were designed to express factors that would make them easy for the immune system to spot, tag, and remember, priming the immune system for a long-term anti-tumor response.

The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTC) in different mice strains, including the one that bore bone marrow, liver, and thymus cells derived from humans, mimicking the human immune microenvironment. Shah’s team also built a two-layered safety switch into the cancer cell, which, when activated, eradicates ThTCs if needed. This dual-action cell therapy was safe, applicable, and efficacious in these models, suggesting a roadmap toward therapy. While further testing and development is needed, Shah’s team specifically chose this model and used human cells to smooth the path of translating their findings for patient settings.