Lifeboat Foundation

The human brain is made up of two kinds of matter: the nerve cell bodies (gray matter), which process sensation, control voluntary movement, and enable speech, learning and cognition, and the axons (white matter), which connect cells to each other and project to the rest of the body.

Historically, scientists have concentrated on the gray matter of the cortex, figuring that’s where the action is, while ignoring white matter, even though it makes up half the brain. Researchers at Vanderbilt University are out to change that.

For several years, John Gore, Ph.D., director of the Vanderbilt University Institute of Imaging Science, and his colleagues have used functional magnetic resonance imaging (fMRI) to detect blood oxygenation-level dependent (BOLD) signals, a key marker of brain activity, in white matter.

Scientists at Kyushu University report that turning brain immune cells into neurons restores brain function after stroke-like injury in mice. Their findings suggest that replenishing neurons from immune cells could be a potential avenue for treating stroke in humans.

The findings are published in PNAS in an article titled, “Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke.”

“Although generating new neurons in the ischemic injured brain would be an ideal approach to replenish the lost neurons for repairing the damage, the adult mammalian brain retains only limited neurogenic capability,” wrote the scientists. “Here, we show that direct conversion of microglia/macrophages into neurons in the brain has great potential as a therapeutic strategy for ischemic brain injury.”

A recent study in Psychiatry Research: Neuroimaging revealed that individuals with high depression scores show increased activity in frontal brain regions during visuospatial memory tasks, despite similar behavioral performance to those with low depression scores. Researchers concluded that the heightened brain activity might represent a compensatory effort…

Experiments suggest that sleep doesn’t cut you off from the outside world as much as scientists had thought.

Neurotechnology will improve our lives in many ways. However, to sustain a world where our neurobiological data (in some cases perhaps including our innermost thoughts and feelings) remains properly secure, we must invest in both policy and technology that prevents bad actors from stealing private information or even directly manipulating people’s brains. We don’t want the very real possibility of ‘telepathy’ and ‘mind control’ to harm people and society. So, let’s start laying the groundwork now to ensure the best possible neurotech future! #neurotech #future #policy #neuroscience

We provide a Perspective highlighting the significant ethical implications of the use of fast-developing neurotechnologies in humans, as well as the regulatory frameworks and guidelines needed to protect neurodata and mental privacy.

Neurons, the main cells that make up our brain and spinal cord, are among the slowest cells to regenerate after an injury, and many neurons fail to regenerate entirely. While scientists have made progress in understanding neuronal regeneration, it remains unknown why some neurons regenerate and others do not.

Using single-cell RNA sequencing, a method that determines which genes are activated in individual cells, researchers from University of California San Diego School of Medicine have identified a new biomarker that can be used to predict whether or not neurons will regenerate after an injury. Testing their discovery in mice, they found that the biomarker was consistently reliable in… More.

Researchers from University of California San Diego have identified a new biomarker that can predict whether or not neurons will regenerate after an injury. The findings could help scientists develop regenerative therapies for spinal cord injuries and other neurological conditions.

Before epilepsy was understood to be a neurological condition, people believed it was caused by the moon, or by phlegm in the brain. They condemned seizures as evidence of witchcraft or demonic possession, and killed or castrated sufferers to prevent them from passing tainted blood to a new generation.

Today we know epilepsy is a disease. By and large, it’s accepted that a person who causes a fatal traffic accident while in the grip of a seizure should not be charged with murder.

That’s good, says Stanford University neurobiologist Robert Sapolsky. That’s progress. But there’s still a long way to go.

Continue reading “Stanford scientist, after decades of study, concludes: We don’t have free will” »

Researchers from University of California San Diego School of Medicine have used single-cell RNA sequencing (scRNA-seq) to identify a pattern of gene expression that can be used to predict whether or not neurons will regenerate after an injury. Tests in mice showed that this “Regeneration Classifier” was consistently reliable in predicting the regeneration potential of neurons across the nervous system and at different developmental stages. Conditional gene deletion then validated a role for NFE2L2 (or NRF2), a master regulator of antioxidant response, in corticospinal tract regeneration.

“Single-cell sequencing technology is helping us look at the biology of neurons in much more detail than has ever been possible, and this study really demonstrates that capability,” said senior author Binhai Zheng, PhD, professor in the Department of Neurosciences at UC San Diego School of Medicine. “What we’ve discovered here could be just the beginning of a new generation of sophisticated biomarkers based on single-cell data.” Zheng and colleagues reported on their findings in Neuron, in a paper titled “Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration.” In their paper the team concluded, “Our data demonstrate a universal transcriptomic signature underlying the regenerative potential of vastly different neuronalpopulations and illustrate that deep sequencing of only hundreds of phenotypically identified neurons has the power to advance regenerative biology.”

Neurons are among the slowest cells to regenerate after an injury. While scientists have made progress in understanding neuronal regeneration, it remains unknown why some neurons regenerate and others do not.

Study finds that in worms, the HSN neuron uses multiple chemicals and connections to orchestrate egg-laying and locomotion over the course of several minutes.

A new MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances. Their stated goal is to make a better world through education, research, and innovation.