They treated three patients with recurrent glioblastoma using a variant of an existing CAR-T therapy, adding additional antibodies to the treatment — and the results were truly astounding.
According to the paper published in The New England Journal of Medicine, one patient saw their tumor decrease in size by 18.5% two days after the treatment, and by day 69, the tumor had decreased by 60.7%, while another saw their ‘tumor regress rapidly’, according to Mass General Brigham.
After the third patient was treated, an MRI showed that a single infusion had led to a ‘near-complete tumor regression’ in just five days.
Joint research led by Yu Toyoshima and Yuichi Iino of the University of Tokyo has demonstrated individual differences in, and successfully extracted commonalities from, the whole-brain activity of roundworms. The researchers also found that computer simulations based on the whole-brain activity of roundworms more accurately reflect real-brain activity when they include so-called “noise,” or probabilistic elements. The findings were published in the journal PLOS Computational Biology.
The roundworm Caenorhabditis elegans is a favorite among neuroscientists because its 302 neurons are completely mapped. This gives a fantastic opportunity to reveal their neural mechanism at a systems level. Thus far, scientists have been making progress in revealing the different states and patterns of each neuron and the assemblies they form. However, how these states and patterns are generated has been a less explored frontier.
First, the team of scientists measured the neural activity of each cell that makes up a primitive brain in the roundworms’ head area. To achieve this, the worms were placed in a microfluidic chip, a tiny device designed for worms to be able to “wiggle” backward and forward while keeping them within the field of view of the objective lens. Then, using a confocal microscope, the scientists filmed how the neurons reacted to changes in salt concentrations.
A collaborative project to bring the promise of cell therapy to patients with a deadly form of brain cancer has shown dramatic results among the first patients to receive the novel treatment.
In a paper published Wednesday in The New England Journal of Medicine, researchers from Mass General Cancer…
Cutting-edge therapy shrinks tumors in early glioblastoma trial.
Groundbreaking graphene neurotechnology developed by ICN2 and collaborators promises transformative advances in neuroscience and medical applications, demonstrating high-precision neural interfaces and targeted nerve modulation.
A study published in Nature Nanotechnology presents an innovative graphene-based neurotechnology with the potential for a transformative impact in neuroscience and medical applications. This research, spearheaded by the Catalan Institute of Nanoscience and Nanotechnology (ICN2) together with the Universitat Autònoma de Barcelona (UAB) and other national and international partners, is currently being developed for therapeutic applications through the spin-off INBRAIN Neuroelectronics.
Chinese ambassador Chen Xu called for the high-quality development of artificial intelligence (AI), assistance in promoting children’s mental health, and protection of children’s rights while delivering a joint statement on behalf of 80 countries at the 55th session of the United Nations Human Rights Council (UNHRC) on Thursday.
Chen, China’s permanent representative to the UN Office in Geneva and other international organizations in Switzerland, said that artificial intelligence is a new field of human development and should adhere to the concept of consultation, joint construction, and shared benefits, while working together to promote the governance of artificial intelligence.
The new generation of children has become one of the main groups using and benefiting from AI technology. The joint statement emphasized the importance of children’s mental health issues.
Analyzing cells from patients with neuromyelitis optica spectrum disorder, researchers show transfers of patient-derived extracellular vesicles rich in the apolipoprotein APOE alleviate neuroinflammation and slow astrocyte loss in a mouse model of this severe autoimmune disease.
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APOE was augmented in astrocytic extracellular vesicles from patients with neuromyelitis optica spectrum disorder and decreased brain lesions in a mouse model.
Research involving mice and samples from patients with multiple sclerosis reveals how anti-CD20 antibodies such as ocrelizumab protect neurons in gray matter, and ties the treatment’s effects to elevated levels of BAFF.
