Lifeboat Foundation

Microsoft’s ChatGPT-powered Bing search engine is sending “unhinged” messages to users, telling lies, sulking, gaslighting, questioning why it exists, and more. Martin Ciupa discusses ChatGPT, large language models, and artificial intelligence research.

Martin Ciupa is a subject matter expert on artificial intelligence, communications and information technology. Martin is the CEO of Remoscope Inc, an AI-based Telehealth startup, and an advisor & consultant to Mindmaze, a Unicorn Neurotech company focuses on applying advanced neuroscience to everyday life.

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How the Big Bang gave us time, explained by theoretical physicist Sean Carroll.

Up next, The Universe in 90 minutes: Time, free will, God, & more ► https://youtu.be/tM4sLmt1Ui8

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In a recent study published in Cell, researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

Despite being linked to rare genetic forms, all eight NDD hallmarks (cellular/molecular processes) also contribute to sporadic NDDs. In addition, they contribute to neuronal loss in preclinical (animal) models and NDD patients, manifesting as an altered molecular (hallmark) biomarker.

An NDD patient could have defects in multiple NDD hallmarks. However, the primary NDD hallmark depends on the NDD insult and the neuronal susceptibility and resilience, i.e., one’s ability to handle insults in the affected brain region.

Scientists have identified the exact point at which healthy brain proteins are shocked into the tangled mess that is commonly associated with Alzheimer’s disease.

Researchers at the University of California Santa Barbara (UCSB) are h opeful that the new laboratory technique behind the discovery can be used to directly study the ‘never-before-seen’ early stages of many neurodegenerative diseases.

Tau proteins are abundant in the human brain. At first, these proteins look like tiny pieces of string inside neurons. As they fold and bind together with structural elements called microtubules, however, they create a sort of skeleton for brain cells that helps them function properly.

Glioblastomas are the most common malignant tumors of the adult brain. They resist conventional treatment, including surgery, followed by radiation therapy and chemotherapy. Despite this armamentarium, glioblastomas inexorably recur.

In a new study published in Nature Communications, Isabelle Le Roux (CNRS) and her colleagues from the “Genetics and development of brain tumors” team at Paris Brain Institute have shown that the elimination of senescent cells, i.e., cells that have stopped dividing, can modify the tumor ecosystem and slow its progression. These results open up new avenues for treatment.

Glioblastoma, the most common adult brain cancer, affects 2 to 5 in 100,000 individuals. While the incidence of the disease is highest in those between 55 and 85 years old, it is increasing in all age groups. This effect can’t be attributed to improved diagnostic techniques alone, suggesting the influence of environmental factors hitherto unidentified.

Year 2019 face_with_colon_three

Scientists can finally explain the ‘breakthrough’ experience.

Year 2021 Basically dmt may be a sorta chemical based computer that shapes our reality which could help understand why sometimes people have disorders of reality perception.

Do we see the world as it really is, or are we creating our own reality? We delve into the neuroscience behind the world that we experience.

Membrane-permeable psychedelics promote cortical neuron growth by activating intracellular serotonin 2A receptors.

Can we objectively tell how fast we are aging? With a good measure, scientists might be able to change our rate of aging to live longer and healthier lives. Researchers know that some people age faster than others and have been trying to concisely measure the internal physiological changes that lead to deteriorating health with age.

For years, researchers have been using clinical factors normally collected at physicals, like hypertension, cholesterol and weight, as indicators to predict aging. The idea was that these measures could determine whether someone is a fast or slow ager at any point in their life cycle. But more recently, researchers have theorized that there are other biological markers that reflect aging at the molecular and cellular level. This includes modifications to a person’s genetic material itself, or epigenetics.

Continue reading “Epigenetic and social factors both predict aging and health, but new research suggests one might be stronger” »