Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience – Page 135

stores and retrieves important information, such as domain-specific knowledge and memories. One dimension of human memory is the ability to link various aspects of experience to specific life events.

Past studies have suggested that this memory-related process is supported by phase precession, which is a shift in the timing at which specific neurons are fired. Up until now, however, this hypothesis had not been confirmed experimentally.

Researchers at the University of California, Davis, Harvard Medical School, Toronto Western Hospital and Cedars-Sinai Medical Center recently carried out a study aimed at probing the relationship between phase precession and memory.

Read more | >

Intestinal stem cells play an important role in maintaining intestinal homeostasis and repairing damaged epithelial tissue. These cells function in a regenerative manner to generate new tissue throughout the growth phase and repair damaged tissue during the aging process.101 The interactions between the gut microbiome and intestinal stem cells are crucial because, if this interaction is comprehended, it may be possible to address various disorders that require stem cell therapy, heal wounds, and improve the durability of organ transplants.101 A recent study showed a connection between hematopoietic stem cells and the microbiome through altering metabolic stress.66 Therefore, the microbiota is crucial for maintaining microbial homeostasis, regulating metabolism, and the innate and adaptive immune systems.101 Furthermore, the study reveals that compositional alterations in the gut microbiome driven by dysbiosis are related to stem cell aging, metabolic dysregulations, stem cells’ epigenetic instability, and abnormal immune system activation.66

In the field of anti-aging, stem cells are regarded to have great potential. In numerous organs, it has been demonstrated that as we age, stem cells lose their capacity for self-renewal and differentiation and run out of resources.89 The emergence of anti-aging medications should address the dysregulation caused by aging that affects stem cells’ capacity for differentiation and self-renewal by re-regulating intrinsic and extrinsic variables. The host microbiome, hormones, local immune system, systemic inflammation, and niche structure are just a few examples of microenvironmental and systemic factors that influence stem cell aging.66

Endogenous ethanol is a class of microbiological metabolites. Proteobacteria, including E. coli and other Enterobacteriaceae, produce ethanol with bacterial origins. High endogenous ethanol levels in the human hippocampus inhibit proliferating stem cells and reduce progenitor and stem cells.102 Additionally, when more ethanol accumulates in the gut, it enhances the permeability of the gut by disrupting epithelial tight junctions, particularly zonula occludens. This enables the movement of pathogenic microbes, their endotoxins, and ethanol across the epithelial layer, causing more immediate and adverse effects on tissues. As a result, the stem cell reserve depletes, hastening the aging process and compensating for damaged tissues.103

Read more | >

Fascinating as this may sound, not all dreams serve as gateways to parallel timelines. Whether dreams return is key here. “Recurring dreams, especially those with vivid and consistent scenarios, might suggest deeper connections to other realities,” Leong claims. On the other hand, dreams tied to personal experiences often feel disjointed, with distorted time. The most surreal and incomprehensible dreams are likely the subconscious processing your life here on Earth, he says. But, if it feels like you’re visiting the dream rather than imagining it—like a play with a beginning, middle, and end—you probably are visiting this other world, under Leong’s hypothesis.

Leong also hints that strong emotions in persistent dreams could offer cosmic clues—signals of how another version of you is experiencing life in a parallel world. “Say you have a repetitive dream of being stuck in high school,” he suggests. “While it may reflect unresolved psychological themes, such as feelings of stagnation or anxiety about personal growth, it could also indicate that in another reality, you are still in high school, dealing with the same challenges your waking self has moved beyond.” This emotional resonance—like the frustration of being stuck—could ripple across dimensions, creating a feedback loop between your conscious mind here and one of your alter egos elsewhere.

YET, AS CAPTIVATING AS THIS HYPOTHESIS MIGHT BE, it runs into a significant problem: there’s no empirical evidence to back it up. Quantum phenomena, such as entanglement and nonlocality, challenge our traditional views on time and space. Yet, no scientific studies conclusively support the idea that dreams are portals to other worlds. Mainstream neuroscience and cognitive science, on the other hand, find this hypothesis heretical—if not downright unscientific.

Read more | >

Anikeeva added, “Yes, it is a record-breaking particle, but it’s not as record-breaking as it could be.”

Although that is still a work in progress, the team has ideas about how to move forward.

Large-scale safety studies are one of the additional steps that would be necessary to move these nanodiscs from basic research using animal models to clinical use in humans, “which is something academic researchers are not necessarily most well-positioned to do,” according to Anikeeva.

Read more | >

An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells.

The research, published in Nature Communications, offers exciting potential for advancing our understanding and treatment of common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.

Neural stem cells are the source of the brain’s primary functional cells. After the initial development of the brain, typically enter a dormant state, conserving energy and resources. They re-awaken only when the brain needs them, such as after an injury or with physical exercise.

Read more | >