Summary: Neural crest stem cells, a rare type found in skin and other tissues, are uniquely capable of reprogramming into different cell types, challenging the prevailing belief that any mature cell can be reprogrammed. The study reveals that cellular reprogramming is likely limited to these specialized stem cells rather than all mature cells.
Neural crest stem cells are present in skin, bone, and connective tissue, with a natural predisposition for transformation due to their origin in embryonic development. This finding could reshape strategies for stem cell therapies, emphasizing the role of neural crest cells in treating neurodegenerative diseases. The team hopes their work will refine cell reprogramming approaches and inspire further research into the specific potentials of stem cell types.
In his most recent book, neuroscientist and psychoanalyst Mark Solms tackles a philosophical puzzle: Why should we have consciousness? Why does life feel like something at all?
A key challenge in the effort to link brain activity with behavior is that brain activity, measured by functional magnetic resonance imaging (fMRI), for instance, is extraordinarily complex. That complexity can make it difficult to find recurring activity patterns across different people or within individuals.
In a new study, Yale researchers were able to take fMRI data, reduce its complexity, and in doing so, uncover stable patterns of activity shared across more than 300 different people. The findings, researchers say, are a promising step forward in uncovering biomarkers for psychiatric disorders.
The study was published Sept. 24 in the journal PLOS Biology.
Dr. Alexander Rosenberg is the R. Taylor Cole Professor of Philosophy at Duke University. He has been a visiting professor and fellow at the Center for the Philosophy of Science, at the University of Minnesota, as well as the University of California, Santa Cruz, and Oxford University, and a visiting fellow of the Philosophy Department at the Research School of Social Science, of the Australian National University. In 2016 he was the Benjamin Meaker Visiting Professor at the University of Bristol. He has held fellowships from the National Science Foundation, the American Council of Learned Societies, and the John Simon Guggenheim Foundation. In 1993, Dr. Rosenberg received the Lakatos Award in the philosophy of science. In 2006–2007 he held a fellowship at the National Humanities Center. He was also the Phi Beta Kappa-Romanell Lecturer for 2006–2007. He’s the author of both fictional and non-fictional literature, including The Atheist’s Guide to Reality, The Girl from Krakow, and How History Gets Things Wrong. In this episode, we focus on Dr. Rosenberg’s most recent book, How History Gets Things Wrong, and also a little bit on some of the topics of The Atheist’s Guide to Reality. We talk about the theory of mind, and how it evolved; the errors with narrative History, and the negative consequences it might produce; mind-brain dualism; what neuroscience tells us about how our brain and cognition operate; social science, biology, and evolution; the role that evolutionary game theory can play in explaining historical events and social phenomena; why beliefs, motivations, desires, and other mental constructs might not exist at all, and the implications for moral philosophy; if AI could develop these same illusions; and nihilism.
Time Links: 01:17 What is theory of mind, and how did it evolve? 06:16 The problem with narrative History. 08:17 Is theory of mind problematic in modern societies? 11:41 The issue with mind-brain dualism. 13:23 The concept of “aboutness” 15:36 Neuroscience, and no content in the brain. 22.21 What “causes” historical events? 28:09 Why the social sciences need more biology and evolution. 37:13 Evolutionary game theory, and understanding social phenomena. 41:06 The implications for moral philosophy of not having beliefs. 44:34 About “moral progress” 47:41 The usefulness of thought experiments in Philosophy. 49:58 The theory of mind will not be going away anytime soon. 51:37 Could AI systems have these same cognitive illusions? 53:13 A note on nihilism and morality. 57:38 Follow Dr. Rosenberg’s work! – Follow Dr. Rosenberg’s work: Faculty page: https://tinyurl.com/ydby3b5f. Website: http://www.alexrose46.com/ Books: https://tinyurl.com/yag2n2fn. – A HUGE THANK YOU TO MY PATRONS: KARIN LIETZCKE, ANN BLANCHETTE, BRENDON J. BREWER, JUNOS, SCIMED, PER HELGE HAAKSTD LARSEN, LAU GUERREIRO, RUI BELEZA, MIGUEL ESTRADA, ANTÓNIO CUNHA, CHANTEL GELINAS, JIM FRANK, AND JERRY MULLER!
I also leave you with the link to a recent montage video I did with the interviews I have released until the end of June 2018: https://youtu.be/efdb18WdZUo.
Alzheimer’s disease, fronto temporal dementia and progressive supra nuclear palsy. Using this study design, the investigators found four genes that marked vulnerable neurons across all three disorders, highlighting pathways that could be used to develop new therapeutic approaches.
The discovery of genes that marked vulnerable neurons could open options for therapeutic approaches.
At some point in your life, you must’ve experienced a lightbulb moment when an amazing idea just popped into your head out of nowhere. But what is your brain doing during these brief periods of creativity?
Researchers from the University of Utah Health and Baylor College of Medicine looked into the origin of creative thinking in the brain. They found that different parts of the brain work together to produce creative ideas, not just one particular area.
“Unlike motor function or vision, they’re not dependent on one specific location in the brain,” Ben Shofty, the senior author of the study and an assistant professor of neurosurgery at the Spencer Fox Eccles School of Medicine, said. “There’s not a creativity cortex.”
Philosopher Daniel Dennett explains how his functionalist perspective can shed some light on the apparent mystery of conscious experience. Interviewed by Louis Godbout.
(Aria from J.S. Bach’s Goldberg Variations played by Andrew Rangell, Keyboard Masterworks, Steinway \& Sons).
Researchers have successfully demonstrated how astroglia—cells that support the functioning of the brain—can be reprogrammed into cells resembling interneurons.
Daniel C. Dennett is one of the most influential philosophers of our time, perhaps best known in cognitive science for his multiple drafts (or “fame in the brain”) model of human consciousness, and to the secular community for his 2006 book Breaking the Spell. Author and co-author of two-dozen books, he’s the Austin B. Fletcher Professor of Philosophy, and Co-Director of the Center for Cognitive Studies at Tufts University, where he taught our very own Point of Inquiry host Lindsay Beyerstein.
Beyerstein and Dennett catch up to discuss Dennett’s newest book, From Bacteria to Bach and Back: The Evolution of Minds. It’s a fresh look at Dennett’s earlier work on the subject of consciousness, taken in new directions as he seeks a “bottom-up view of creation.” Join Dennett and Beyerstein as they discuss the how’s and why’s of consciousness, not just from an evolutionary and neurological standpoint, but also through the lenses of computer science and human culture.
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