An international team of scientists, including researchers from Harvard University and the University of Zurich, analyzed clinical trial results 777 elderly Swiss adults to test the potential anti-aging benefits of supplements and exercise.
While there’s no perfect way to measure biological aging, the researchers used tools that help measure age-related decline in the cells and organs, including factors like brain health and heart health.
They looked at participants who underwent one of eight longevity treatments over three years, including exercising and supplementing omega-3s, vitamin D, or both.
Josh Mitteldorf suggests new protocol for experimental young plasma therapy.
Scientists explore concentrated plasma infusions for stronger anti-ageing effects.
01-Feb-2025Key points from article :
Scientists have long observed the remarkable rejuvenation effects of young plasma in ageing rats, but translating these findings into human therapies has been slow due to intellectual property barriers and funding challenges. In the meantime, a niche industry has emerged in Texas, where ageing individuals can receive plasma infusions from young donors for tens of thousands of dollars. However, these treatments, which replace about 35% of a patient’s plasma, fall short of the dramatic regeneration seen in laboratory animals. Researchers suspect that the exosome dosages in these human procedures are too low to match the full rejuvenation potential seen in rats.
To address this, a new approach suggests concentrating young plasma by removing excess water, allowing for higher doses without overloading the circulatory system. Freeze-drying plasma, a long-standing technology, could be adapted to reconstitute plasma at three or more times its normal strength. However, modifications would be necessary—such as removing platelets to avoid clotting risks and adjusting albumin levels for safety.
A key question remains: Can young exosomes permanently reprogram the body’s ageing process, or will ongoing infusions be required? If the body starts producing its own youthful exosomes after treatment, the therapy could be a game-changer. If not, frequent infusions might be necessary, making the procedure less practical. While uncertainty remains, results from animal studies provide hope that young plasma could lead to longer-lasting rejuvenation in humans.
Outer Space, Inner Space, and the Future of Networks. Synopsis: Does the History, Dynamics, and Structure of our Universe give any evidence that it is inherently “Good”? Does it appear to be statistically protective of adapted complexity and intelligence? Which aspects of the big history of our universe appear to be random? Which are predictable? What drives universal and societal accelerating change, and why have they both been so stable? What has developed progressively in our universe, as opposed to merely evolving randomly? Will humanity’s future be to venture to the stars (outer space) or will we increasingly escape our physical universe, into physical and virtual inner space (the transcension hypothesis)? In Earth’s big history, what can we say about what has survived and improved? Do we see any progressive improvement in humanity’s thoughts or actions? When is anthropogenic risk existential or developmental (growing pains)? In either case, how can we minimize such risk? What values do well-built networks have? What can we learn about the nature of our most adaptive complex networks, to improve our personal, team, organizational, societal, global, and universal futures? I’ll touch on each of these vital questions, which I’ve been researching and writing about since 1999, and discussing with a community of scholars at Evo-Devo Universe (join us!) since 2008.
For fun background reading, see John’s Goodness of the Universe post on Centauri Dreams, and “Evolutionary Development: A Universal Perspective”, 2019.
John writes about Foresight Development (personal, team, organizational, societal, global, and universal), Accelerating Change, Evolutionary Development (Evo-Devo), Complex Adaptive Systems, Big History, Astrobiology, Outer and Inner Space, Human-Machine Merger, the Future of AI, Neuroscience, Mind Uploading, Cryonics and Brain Preservation, Postbiological Life, and the Values of Well-Built Networks. He is CEO of Foresight University, founder of the Acceleration Studies Foundation, and co-founder of the Evo-Devo Universe research community, and the Brain Preservation Foundation. He is editor of Evolution, Development, and Complexity (Springer 2019), and Introduction to Foresight: Personal, Team, and Organizational Adaptiveness (Foresight U Press 2022). He is also author of The Transcension Hypothesis (2011), the proposal that universal development guides leading adaptive networks increasingly into physical and virtual inner space.
A talk for the ‘Stepping into the Future‘conference (April 2022).
A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers at Penn State.
Materials created up to this point to mimic tissues and extracellular matrices (ECMs)—the body’s biological scaffolding of proteins and molecules that surrounds and supports tissues and cells—have all had limitations that hamper their practical applications, according to the team. To overcome some of those limitations, the researchers developed a bio-based, “living” material that encompasses self-healing properties and mimics the biological response of ECMs to mechanical stress.
They published their results in Materials Horizons, where the research was also featured on the cover of the journal.
As one of the most hard-working tissues in the body, the heart muscle is subject to incessant wear and tear due to aging and various health conditions. Unsurprisingly, heart failure is one of the most common age-related causes of death.
Cryonic freezing offers a pathway to reap future medical technologies today by preserving someone for future restoration, but what would the impact of this technology be on civilization?
Credits: Cryonics: Frozen Civilizations. Science & Futurism with Isaac Arthur. Episode 273; January 14, 2021 Written, Produced & Narrated by Isaac Arthur.
Editors: Jason Burbank. Jerry Guern. Keith Blockus.
Chromatin, the mix of DNA and protein that houses each cell’s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King’s College London.
Scientists believe this may reveal how the body can cope with the inevitable “wear-and-tear” of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.
Proteins, much like the rest of the body, change when aging. This is especially the case for the histone proteins that make up chromatin, which may “live” for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring chemical changes to the protein called post-translational modifications, or PTMs.
Explore how science, innovation, and consumer demand are transforming the pursuit of longevity, from groundbreaking research to personalized health solutions.
Thymic injury leads to reduced T cell production and makes patients more vulnerable to infections and cancers. Lemarquis et al. identify a population of recirculating regulatory T (Treg) cells that mediate regeneration in the injured thymus, partially through amphiregulin. An analogous population of Treg cells expressing CD39 and ICOS is found in humans, suggesting therapeutic avenues for boosting thymic regeneration to address aging-and treatment-induced immunosuppression.
