A seaweed compound just reversed ageing in mice. Humans are next.
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Take note of the name: ReHMGB1. A new study pinpoints this protein as being able to spread the wear and tear that comes with time as it quietly travels through the bloodstream. This adds significantly to our understanding of aging.
Short for reduced high mobility group box 1, ReHMGB1 triggers senescence in cells, permanently disabling them. It doesn’t just do this locally; it can send damaging signals throughout the body, particularly in response to injuries or disease.
“An important question in aging research is why senescent cells increase with age,” write the study authors, led by researchers from the Korea University College of Medicine.
For 25 years, scientists at Northwestern Medicine have been studying individuals aged 80 and older—dubbed “SuperAgers”—to better understand what makes them tick.
These unique individuals, who show outstanding memory performance at a level consistent with individuals who are at least three decades younger, challenge the long-held belief that cognitive decline is an inevitable part of aging.
Over the quarter-century of research, the scientists have seen some notable lifestyle and personality differences between SuperAgers and those aging typically—such as being social and gregarious—but “it’s really what we’ve found in their brains that’s been so earth-shattering for us,” said Dr. Sandra Weintraub, a professor of psychiatry and behavioral sciences and neurology at Northwestern University Feinberg School of Medicine.
A paper coauthored by geneticist George Church has been retracted following an internal review at a university where several coauthors are based.
The article appeared in the Proceedings of the National Academy of Sciences in 2022. The work supports an anti-aging gene therapy developed by BioViva, a company for which Church serves as an adviser. The paper’s authors claim cytomegalovirus (CMV) can be a gene therapy vector for a treatment for “aging-associated decline” that can be inhaled or injected monthly.
The work has been cited 41 times, two of which are citations from corrections to the article, according to Clarivate’s Web of Science.
Aging infrastructure, soaring electricity demand, renewable integration, and climate risks are driving the largest US grid modernization effort in history.
The idea of taking blood from the young to rejuvenate the elderly is getting an increasing amount of attention from scientists, and a new study has shown how some of the youthful properties of our skin can be restored with this kind of blood swap.
A special 3D human skin model was set up in the lab by researchers, who then tested the effects of young blood serum on the skin cells. By itself, the serum had no effect, but when bone marrow cells were added to the experiment, anti-aging signals were detected in the skin.
It appears that the young blood serum interacts with the bone marrow cells in specific ways to roll back time in skin cells. The study was led by scientists from Beiersdorf AG, a skin care company in Germany, who say their findings have huge potential in helping us understand anti-aging mechanisms.