Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 645

Healthy living isn’t meaningless, but while all of us can make positive lifestyle modifications, genes play a massive role in longevity — or there would be no species variation. We’re still discovering exactly which genes provide a longevity boost and what they do, but we now know 7 variants could help give you an advantage.

The search for a longevity gene

Previous efforts to search out a ‘longevity gene’ have been largely unsuccessful, so researchers led by Stuart Kim at Stanford decided to focus on ‘bad’ gene variants this time — or more crucially a lack of them. They analysed 800 people over 100 and 5000 people over 90 and found that while many variants are common in the average person, possession of fewer ‘bad’ versions of 5 crucial genes was indeed associated with longevity. Many long-lived individuals are able to avoid chronic disease despite harmful lifestyle choices like smoking, and this could be one of the explanations. These confirmed 5 add to 2 already associated with longer lifespans.

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Robots and artificial intelligence (AI) will dominate legal practice within 15 years, perhaps leading to the “structural collapse” of law firms, a report predicting the shape of the legal market has envisaged.

Civilisation 2030: The near future for law firms, by Jomati Consultants, foresees a world in which population growth is actually slowing, with “peak humanity” occurring as early as 2055, and ageing populations bringing a growth in demand for legal work on issues affecting older people.

This could mean more advice needed by healthcare and specialist construction companies on the building and financing of hospitals, and on pension investment businesses, as well as financial and regulatory work around the demographic changes to come; more age-related litigation, IP battles between pharmaceutical companies, and around so-called “geriatric-tech” related IP.

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By 2034 the annual cost of diabetes in the US will be comparable to the market capitalization of Google.

Diabetes comes in two main forms, type 1 and type 2. Type 1 diabetes is caused by a failure of the body to produce the hormone insulin that helps sugar molecules to be absorbed by your cells. This type of diabetes is commonly caused by an autoimmune reaction in which the body attacks the pancreas, the gland that produces insulin, and normally occurs during childhood. The second form is when the body becomes insensitive to insulin; the hormone is still there but the cells no longer respond to it. In the Dutch language this form used to be called ‘ouderdomsdiabetes’ meaning ‘diabetes of old age’. This description is no longer accurate as even teenagers have now been diagnosed with it.

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This tongue-in-cheek article highlights an interesting experience I had a few days ago on the Immortality Bus in North Carolina:

One wants to live forever, the other wants to push reset on the US Constitution. Both are running for president in 2016. As Republican and Democrat presidential candidates prepare for December’s debates, pioneering Transhumanist Zoltan Istvan and cybersecurity legend John McAfee met for the first time this week for their own debate, over several large drinks in a motel bar.

Istvan, who is currently touring the US aboard a coffin-shaped campaign bus, and McAfee both have technology at the core of their campaign policies, but in terms of specific policy this is where the similarities end.

“I can’t think of a more horrific concept than immortality,” McAfee told Istvan soon after meeting in Charlotte, North Carolina. “It is anti-evolutionary. We need to die and die young preferably; dying is the most beautiful of all things. I’d get behind a platform where you kill everyone at 30. I would fight you tooth and nail to stop you making people live forever.”

John McAfee zoltan istvan elections

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Last week the FDA announced that they have granted permission for the TAME trial. The Targeting Aging with Metformin (TAME) trial is the first human trial specifically looking at an anti-aging drug in humans.

Repurposing An Old Medicine

Metformin is an old drug, first approved in France in 1957, for the treatment of type 2 diabetes and polycystic ovary syndrome (PCOS). However extracts from the French liliac (Galega officinalis), the plant containing a precursor of metformin, has been used to treat frequent urination, a symptom of diabetes, since the Middle Ages. In 2012 in the US about 60 million prescriptions for metformin were written, making metformin the most used antidiabetic drug. Amazingly, every year about 37,000 metric tons of metformin are produced! Metformin is also a super-cheap drug, costing only cents per dose.

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C. elegans roundworm (credit: The Goldstein Lab)

When researchers at The Scripps Research Institute (TSRI) in California administered an antidepressant called mianserin to the Caenorhabditis elegans roundworm in 2007, they discovered the drug increased the lifespan of the “young adulthood” of roundworms by 30–40 per cent.

So, does that mean it will work in humans? Not necessarily. “There are millions of years of evolution between worms and humans,” says TSRI researcher Michael Petrascheck. “We may have done this in worms, but we don’t want people to get the impression they can take the drug we used in our study to extend their own teens or early twenties.”

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