Lifeboat Foundation: Safeguarding Humanity
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Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.

This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.

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“We are very excited about the approval of our protocol,” said Ira S. Pastor, CEO, Bioquark Inc. “With the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we are poised to delve into an area of scientific understanding previously inaccessible with existing technologies.”

Death is defined as the termination of all biological functions that sustain a living organism. Brain death, the complete and irreversible loss of brain function (including involuntary activity necessary to sustain life) as defined in the 1968 report of the Ad Hoc Committee of the Harvard Medical School, is the legal definition of human death in most countries around the world. Either directly through trauma, or indirectly through secondary disease indications, brain death is the final pathological state that over 60 million people globally transfer through each year.

While human beings lack substantial regenerative capabilities in the CNS, many non-human species, such as amphibians, planarians, and certain fish, can repair, regenerate and remodel substantial portions of their brain and brain stem even after critical life-threatening trauma.

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Additionally, recent studies on complex brain regeneration in these organisms, have highlighted unique findings in relation to the storage of memories following destruction of the entire brain, which may have wide ranging implications for our understanding of consciousness and the stability of memory persistence.

“Through our study, we will gain unique insights into the state of human brain death, which will have important connections to future therapeutic development for other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states, as well as a range of degenerative CNS conditions, including Alzheimer’s and Parkinson’s disease,” said Dr. Sergei Paylian, Founder, President, and Chief Science Officer of Bioquark Inc.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. However, once humans transition through the brain death window, currently defined by the medical establishment as “irreversible”, they are technically no longer alive, despite the fact that human bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

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“We look forward to working closely with Bioquark Inc. on this cutting edge clinical initiative,” said Dr. Himanshu Bansal, Managing Director of Revita Life Sciences.

About Bioquark, Inc.

Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.

About Revita Life Sciences

Revita Life Sciences is a biotechnology company focused on the development of stem cell therapies that target areas of significant unmet medical need. Revita is led by Dr. Himanshu Bansal MD, PhD. who has spent over two decades developing novel MRI based classifications of spinal cord injuries as well as comprehensive treatment protocols with autologous tissues including bone marrow stem cells, dural nerve grafts, nasal olfactory tissues, and omental transposition.

Taking their cue from salamander regeneration, a team led by the University of New South Wales says that a stem cell therapy capable of regenerating any human tissue damaged by injury, disease, or aging could be available within a few years, thanks to an innovative new technique.

While stem cells have worked wonders in medicinal research, showing signs of curing everything from spinal cord injuries to blindness, they’ve always had their shortcomings. But one study is promising a new “game changing” technique for stem cells.

Taking their cue from salamander regeneration, new research led by the University of New South Wales says that a stem cell therapy capable of regenerating any human tissue damaged by injury, disease, or aging could be available within a few years, through an innovative new technique.

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DARPA taking on the designer viruses and resistant fighting viruses that we hate. Who knows; they may finally find the fountain of youth in the process.

Vaccines are great, but they’re no match for most viruses in play at any given time. This is due largely in part to the ever-changing nature of viruses and the expense and difficulty in developing new vaccines to target them. DARPA wants that reality to change, citing the numerous concerning viruses, past and present, that affect humanity. Under the “INTERCEPT” program, DARPA seeks “shape-shifting” vaccines that adapt to kill off viruses as they evolve.

One of the biggest virus scares at the moment is the zika virus, but ebola was just recently a big issue and other viruses, including influenza and dengue, are a continuous problem. Once someone is infected, the virus is able to “mutate and morph as they reproduce inside their hosts,” says DARPA, making any vaccines quickly obsolete. If the agency’s new INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program proves successful, though, things will change in a big way.

Under the program, DARPA seeks a solution that uses something called TIPs — Therapeutic Interfering Particles — which are described as small entities similar to viruses that are made in labs. TIPs are essentially genetic material packed within a protein shell, something that mimic the way a virus is structured. Because of their similarities, TIPs can enter cells like viruses but don’t proceeded to hijack that cell as viruses do.

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The growth of human and computer intelligence has triggered a barrage of dire predictions about the rise of super intelligence and the singularity. But some retain their skepticism, including Dr. Michael Shermer, a science historian and founding publisher of Skeptic Magazine.

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The reason so many rational people put forward hypotheses that are more hype than high tech, Shermer says, is that being smart and educated doesn’t protect anyone from believing in “weird things.” In fact, sometimes smart and educated people are better at rationalizing beliefs that they hold for not-so-rational reasons. The smarter and more educated you are, the better able you are to find evidence to support what you want to be true, suggests Shermer.

“This explains why Nobel Prize winners speak about areas they know nothing about with great confidence and are sure that they’re right. Just because they have this great confidence of being able to do that (is) a reminder that they’re more like lawyers than scientists in trying to marshal a case for their client,” Shermer said. “(Lawyers) just put together the evidence, as much as you can, in support of your client and get rid of the negative evidence. In science you’re not allowed to do that, you’re supposed to look at all the evidence, including the counter evidence to your theory.”

The root of many of these false hypotheses, Shermer believes, is based in religion. Using immortality as an example, Shermer said the desire to live forever has strong parallels to religious beliefs; however, while there are many making prophecies that technology will insure we’ll live forever, too many people in groups throughout history have made similar yet unfulfilled promises.

“What we’d like to be true is not necessarily what is true, so the burden of proof is on them to go ahead and make the case. Like the cryonics people…they make certain claims that this or that technology is going to revive people that are frozen later…I hope they do it, but you’ve got to prove otherwise. You have to show that you can actually do that.”

Even if we do find a way to live forever, Shermer notes the negatives may outweigh the positives. It’s not just living longer that we want to achieve, but living longer at a high quality of life. There’s not much benefit in living to age 150, he adds, if one is bedridden for 20 or 30 years.

Instead, Shermer compares the process to the evolution of the automobile. While the flying cars promised by 1950’s-era futurists haven’t come to pass, today’s automobile is exponentially smarter and safer than those made 50 or 60 years ago. While forward thinkers have had moments of lucid foresight, humans also have a history of making technology predictions that often don’t turn out to be realized. Often, as is the case with the automobile, we don’t notice differences in technological changes because the changes happen incrementally each year.

“That’s what’s really happening with health and longevity. We’re just creeping up the ladder slowly but surely. We’ve seen hip replacements, organ transplants, better nutrition, exercise, and getting a better feel for what it takes to be healthy,” Shermer says. “The idea that we’re gonna’ have one big giant discovery made that’s going to change everything? I think that’s less likely than just small incremental things. A Utopian (society) where everybody gets to live forever and they’re infinitely happy and prosperous and so on? I think it’s unrealistic to think along those lines.”

Looking at the future of technology, Shermer is equally reticent to buy in to the predictions of artificial intelligence taking over the world. “I think the concern about AI turning evil (and) this dystopian, science fiction perspective is again, not really grounded in reality. I’m an AI optimist, but I don’t think the AI pessimists have any good arguments,” Shermer said

While we know, for the most part, which types of governments work well, we don’t have any similar precedent for complex AI systems. Humans will remain in control and, before we start passing laws and restrictions to curb AI out of fear, Shermer believes we should keep improving our computers and artificial intelligence to make life better, evaluating and taking action as these systems continue to evolve.

Nanomedicine has been something that many in tech expected to be a critical part of the healthcare landscape for over a decade. I am glad to see how quickly the technology is being adopted as part of bio-medical research and treatments for various diseases, etc.

NEW YORK, April 7, 2016 /PRNewswire/ — Nano-based science paving the precision medicine era.

The continued development of new treatments associated with the demographic trends and public health considerations is remarkable. Nanotechnology has been identified as one most relevant key enabling technologies of the last ten years, significantly impacting on many different biomedical developments in a broad spectrum of applications therapeutics, diagnostics, theranostics, medical imaging, regenerative medicine, life sciences research and biosciences, among many others. In fact, nanomedicine is present in all therapeutic areas, exhibiting a perceptible and extensive impact in the treatment and diagnosis of some most concerned diseases.

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In the pages of comic books and on the silver screen, superheroes like Wolverine and Deadpool have a “healing factor” that allows their bodies to regenerate and recover from injuries or illness at an amazing rate – but certainly nothing like that is possible in real life, right?

Amazingly, a team of scientists led by John Pimanda, a hematologist and associate professor at the University of New South Wales in Australia, published a study in Monday’s edition of the journal PNAS reporting that they had successfully reprogrammed bone and fat cells into induced multipotent stem cells (iMS) – the first step to making such a repair system a reality.

As they explained in a statement, stem cell therapies using iMS cells could theoretically repair a fractured bone or fix injured spinal discs, using a technique similar to how salamanders are able to regenerate lost limbs. These treatments could radically alter the field of regenerative medicine, and perhaps most surprisingly, the authors believe they could be available in just a few years. The technique, which has been successfully tested in mice, “is a significant advance on many of the current unproven stem cell therapies, which have shown little or no objective evidence they contribute directly to new tissue formation,” Pimanda said.

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Stem cells, human trials, regenerative medicine, yay!

UNSW researchers say the therapy has enormous potential for treating spinal disc injury and joint and muscle degeneration and could also speed up recovery following complex surgeries where bones and joints need to integrate with the body (credit: UNSW TV)

A stem cell therapy system capable of regenerating any human tissue damaged by injury, disease, or aging could be available within a few years, say University of New South Wales (UNSW Australia) researchers.

Their new repair system, similar to the method used by salamanders to regenerate limbs, could be used to repair everything from spinal discs to bone fractures, and could transform current treatment approaches to regenerative medicine.

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Dear Friends,

This month we at the MMTP are launching our crowdfunding campaign on Lifespan.io. Our Senolytics research is very important to the field of aging and longevity research and if we successfully raise sufficient funds, we will be ready to make a significant impact on aging!

We are seeking like minded groups and organisations to show their support, by becoming our official supporters. Showing your support means your logo will be displayed on some of our official media and website, demonstrating you are standing with us to get this vital work underway.

If you want to get involved beyond donating to our crowdfunding, please get in touch with us at [email protected] or contact us directly on our facebook page.

We have a very real opportunity to change how we age, be part of that change!

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