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How we can use CRISPR/Cas9 to treat the processes of aging.


Oliver Medvedik, Cofounder of the Life Extension Advocacy Foundation and the Lifespan.io Crowdfunding platform, discusses the CRISPR/Cas9 gene editing system in depth and highlights how it may be used to help overcome the diseases and disabilities of aging. He also gives an overview of other promising areas in aging research, such as senescent cell-clearing drugs, or “senolytics”, and “augmentive” compounds that may help restore the body to youthful functionality.

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Please sign this petition to the NIH to help get more funding for aging research.


Every year about two million Americans die of illnesses doctors cannot cure. Cancer afflicts 50% of men and 30% of women. Five hundred and ninety five thousand Americans will die of cancer this year. Millions get heart diseases, strokes, etc. Every year 1,612,552 Americans die of the top 8 illnesses that doctors are unable to cure. Over a 30-year period, 48,376,560 United States citizens will die of the top 8 illnesses. Let us not forget other disabling and potentially curable illnesses. How much is it worth to save them? We have the resources and opportunity to cure age-related disease.

History has shown that medical research actually saves money. We now spend three trillion two hundred billion dollars yearly for health care. The health care expenditures will increase as our population grows with more senior citizens.

Every year we also spend hundreds of billions of dollars for services such as Social Security Disability, welfare, food stamps, special transportation, etc. Medical research will help cut down on the need for these services. It will also extend our lives.

A strong rebuttle to the sick article in the Telegraph which attempts to discredit Zuckerberg and Chan and their commitment to curing diseases.


Science and progress hardly ever stop just because a few cuckoos think we’re going too far. That’s what I tell myself most of the times when I bump into depressingly ill-informed articles about ageing and the diseases of old age. I tell myself that the best thing to do is to just let such articles disappear into oblivion and not give them any extra visibility. However, if instead of a few cuckoos we’re faced with an army of cuckoos, then we’re in for troubles.

At the time of this writing, people who are in favour of or oppose rejuvenation aren’t many, and neither are those who know about it but don’t care. Quite likely, most people in the world haven’t even heard about it yet. What I fear is that, when the advent of rejuvenation biotechnologies will be close, people who oppose rejuvenation will do their best to persuade undecided ones that disease is better than health, and ultimately, provoke an us-vs-them conflict that could jeopardise the cause of rejuvenation. The best way to avoid that conflict is to convince as many people as possible to support rejuvenation biotechnologies before they even arrive, so that when they do, those who oppose them will only be a few cuckoos indeed and not an army. Exposing the intellectual misery of deathist arguments is indubitably a good way of reaching this goal; that’s why I chose to respond to this spectacularly stupid article, instead of just ignoring it.

Lewis doesn’t want to live in a world without diseases. She prefers living in one where diseases are invented.

Connecting the dots between transhumanism, veganism, and caring for animals. My new story for Vice Motherboard:


The answer is bewildering—and it probably won’t be satisfying to plant-loving people. Nonetheless, it will inevitably eliminate most human-caused animal deaths. The answer is transhumanism—the movement that aims to replace human biology with synthetic and machine parts.

You see, the most important goal of transhumanism is to try to overcome death with science and technology. Most cellular degeneration—otherwise known as aging and sickness—comes from the failing of cells. That failure is at least partially caused by the daily act of eating and drinking—of putting foreign objects into our bodies which cells have to consume or discard to try to create energy. Paraxdocially, it’s stressful and hard work for cells to endlessly do this just to live. A simple way to eliminate this Sisyphean task—all the steaks, chocolate donuts, bacon breakfasts, and even my favorite, scotch—is to get rid of human reliance on food and drink entirely.

Transhumanists, like myself, want to get rid of it all. We want to strip you of your stomach, your guts, and even your anus—and replace it all with machine parts and bionics. In the future, there will be no eating, drinking, or defecation.

Fascinating article, and a mostly fair one at that!

“Cryonicists are often dismissed as wasteful, selfish, and narcissistic, and the practice itself is often viewed as an eccentric indulgence for wealthy people with a profound fear of death. And genuine concern exists about the feasibility and viability of cryonics. But as more and more families take the leap into the frozen unknown, there are practical concerns—legal rights, money, consent. And lurking beneath the surface, there is a different fear—that cryonics might just actually work and that signing up for cryonics might be the most insanely rational decision you will ever make.”


In a vat of liquid nitrogen on storage platform 17, the youngest person ever to be put into cryogenic storage has been waiting for the future for one year and eight months.

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Bioquark, Inc., (http://www.bioquark.com) a life sciences company focused on the development of novel, natural bio-products for health, wellness and rejuvenation, has entered a collaboration whereby Forest Organics LLC & I-Beauty Charm LLC, a unique, integrated facial and body cosmetology facility, and their state-licensed, highly skilled skin care specialists, will be utilizing novel, natural Bioquantine™ extract complexes as part of their spa procedures, as well as providing consumer access to a range of proprietary skin care products (http://www.forestorganics.life).

“We are very excited about this first company collaboration in the area of beauty care and cosmetology,” said Ira S. Pastor, CEO, Bioquark Inc. “It is another step forward towards the wide applicability of our natural combinatorial bio-products, across a broad range of health and wellness segments, as well as future franchise opportunities.”

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The integrated Forest Organics LLC & I-Beauty Charm LLC model was conceived by local Tampa business women, Nadia Goetzinger and Tatyana Reshetnikova, to offer a new generation of products and services related to skin beautification and rejuvenation.

“We look forward to working closely with Bioquark Inc. on this initiative and providing an exclusive range of services and products to customers throughout the greater Tampa metropolitan area,” said Ms. Goetzinger”

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About Bioquark, Inc.

Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biopharmaceutical candidates, as well as non-Rx products for the global consumer health and wellness market segments.

About Forest Organics LLC & I-Beauty Charm LLC

Forest Organics LLC & I-Beauty Charm LLC operate a unique, integrated facial and body cosmetology facility providing novel rejuvenative spa and cosmetology services and products.

It has officially been one year since I volunteered to take the first gene therapy to treat biological aging. It has been an amazing year! It began with a great deal of excitement in the weeks leading up to taking the treatment. The excitement of treatment day was followed by months of anticipation before the letdown of not magically reversing visual aging and becoming a 20-year-old biologically again. Even so, the year has been filled with energizing information gleaned from every additional molecular biomarker test that we have done. In this post, I will try to summarize my feelings on several topics as they have evolved throughout the year.

First in Human Use

Being the first person to use any new medical treatment is a complicated endeavor. It is infinitely more complicated when we don’t know the possible outcomes, the perfect dosage, the regimen, or the optimal delivery method. With all of these uncertainties, one is constantly aware that all the excitement and hopes could be squelched in moments. For the same reasons, every small success seems unbelievable, even though they are the results we wanted.

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