Menu

Blog

Archive for the ‘life extension’ category: Page 610

Dec 9, 2015

Scores of Labs Should be Gearing Up to Work on Glucosepane Cross-Link Breakers, But Are They?

Posted by in categories: biotech/medical, chemistry, health, life extension, neuroscience

Glucosepane is one of the most significant mechanisms of aging and yet very few people are working on it!


As we age skin and blood vessels lose their elasticity. People care too much about the skin and too little about the blood vessels, but that is always the way of it. Appearance first and substance later, if at all. Yet you can live inside an aged skin; beyond the raised risk of skin cancer its damaged state arguably only makes life less pleasant, and the present state of medical science can ensure that the numerous age-related dermatological dysfunctions can be kept to a state of minor inconvenience. Loss of blood vessel elasticity, on the other hand, will steadily destroy your health and then kill you. Arterial stiffening causes remodeling of the cardiovascular system and hypertension. The biological systems that regulate blood pressure become dysfunctional as blood vessels depart from ideal youthful behavior, creating a downward spiral of increasing blood pressure and reactions to that increase. Small blood vessels fail under the strain in ever larger numbers, damaging surrounding tissue. In the brain this damage contributes to age-related cognitive decline by creating countless tiny, unnoticed strokes. Ultimately this process leads to dementia. More important parts of the cardiovascular system are likely to fail first, however, perhaps causing a stroke, or a heart attack, or the slower decline of congestive heart failure.

From what is known today, it is reasonable to propose that the two main culprits driving loss of tissue elasticity are sugary cross-links generated as a byproduct of the normal operation of cellular metabolism and growing numbers of senescent cells. Elasticity is a property of the extracellular matrix, an intricate structure of collagens and other proteins created by cells. Different arrangements of these molecules produce very different structures, ranging from load-bearing tissues such as bone and cartilage to elastic tissues such as skin and blood vessel walls. Disrupting the arrangement and interaction of molecules in the extracellular matrix also disrupts its properties. Persistent cross-links achieve this by linking proteins together and restricting their normal range of motion. Senescent cells, on the other hand, secrete a range of proteins capable of breaking down or remodeling portions of the surrounding extracellular matrix, and altering the behavior of nearby cells for the worse.

Continue reading “Scores of Labs Should be Gearing Up to Work on Glucosepane Cross-Link Breakers, But Are They?” »

Dec 8, 2015

Transhumanism Solving Violence and Improving the Human Condition: IQ, EQi, and Intelligence Upgrades

Posted by in categories: biotech/medical, business, computing, cyborgs, life extension, neuroscience, robotics/AI, transhumanism

Can we end violence? Can we create greater emotional well being and intellectual equality for the greater well being of humanity? Will we be able to keep up with machines? How can we augment our intelligence? Could we cure mental illness? After advancements in aging the next major area of research from a standpoint of eliminating personal and global suffering would be upgrades in intelligence. Transhumanist values at their core want to eliminate suffering and existential risk to people’s lives. With well founded logic, these goals are not completely out of reach, it is possible but as usual, we will have to take the complex issue from many angles and from the standpoint of a systems engineer, but let’s look at some fun stuff before we get into the heavy stuff.

The Benefits of Intelligence Upgrades

Continue reading “Transhumanism Solving Violence and Improving the Human Condition: IQ, EQi, and Intelligence Upgrades” »

Dec 8, 2015

Telomerase Therapy to Reverse Cardiovascular Senescence

Posted by in categories: biotech/medical, life extension

Exciting news as another group proposes to explore telomerase therapy for the Cardio Vascular system. This no doubt follows on from DePhino et al work on the P53-telomerase-PCG-1 aging axis work which showed the effects of short telomeres on vascular aging (and other organs) and its direct link to Mitochondrial function and Stem cell Decline via the P53-telomerase-PCG-1 aging axis.

Read more

Dec 6, 2015

Longer Life in a Pill May Already Be Available at Your Local Drug Store

Posted by in categories: biotech/medical, life extension

To most of the scientific community, “anti-aging” is a dirty word.

A medical field historically associated with charlatans and quacks, scientists have strictly restricted the quest for a “longevity pill” to basic research. The paradigm is simple and one-toned: working on model organisms by manipulating different genes and proteins, scientists slowly tease out the molecular mechanisms that lead to — and reverse — signs of aging, with no guarantee that they’ll work in humans.

longer-life-in-a-pill-41But it’s been a fruitful search: multiple drug candidates, many already on the market for immune or psychiatric disorders, have consistently delayed age-associated diseases and stretched the lifespan of fruit flies, roundworms and mice. Yet human trials have been far beyond reach — without the FDA acknowledging “aging” as a legitimate target for drug development, researchers have had no way of pitching clinical trials to the regulatory agency.

Read more

Dec 4, 2015

The Year We Decided to Live Forever

Posted by in category: life extension

In 2015, tech billionaires pursued anti-aging and cheating death like never before.

Read more

Dec 3, 2015

I visited one of the largest megachurches in the US as an atheist Transhumanist presidential candidate — here’s what happened

Posted by in categories: geopolitics, life extension, robotics/AI, transhumanism

A new article on visiting Alabama’s largest megachurch on the Immortality Bus and discussing transhumanism. Make sure to check out the 2-min YouTube video embedded in the story:


The pastor considered whether robots could be saved.

Read more

Dec 3, 2015

Discovery Provides Hope Of More Effective, Safer Cryopreservation

Posted by in categories: cryonics, innovation, life extension, materials

Cryogenics are an old science fiction dream, but today we still struggle to store large tissues without harming them. Now a breakthrough could lead to a safer, more reliable approach.

” This could be an important step toward the preservation of more complex tissues and structures”

Overcoming past challenges

Continue reading “Discovery Provides Hope Of More Effective, Safer Cryopreservation” »

Dec 2, 2015

Can Zoltan Istvan beat Hillary, Trump, and Death itself?

Posted by in categories: geopolitics, life extension, military, robotics/AI, transhumanism

Here’s a very in depth, approximately 6,000 word story (broken into 5 articles) with many pictures on transhumanism–from one of the world’s leading tech sites: The Verge.


Zoltan Istvan is very worried about the superintelligent machines.

He says the war over artificial intelligence will be worse than the Cold War nuclear arms race — much worse. It will be far more deadly, and whoever wins will control the world, eternally. This artificial intelligence might be being developed right now, he says, for all we know. At a government facility in the middle of the Arizona desert, perhaps.

Continue reading “Can Zoltan Istvan beat Hillary, Trump, and Death itself?” »

Dec 2, 2015

A Harvard professor says he can cure aging, but is that a good idea?

Posted by in categories: biotech/medical, life extension

Is the fountain of youth lurking somewhere in the code of life?

Read more

Dec 2, 2015

Telomeres length testing, longevity genotyping

Posted by in category: life extension

Non-invasive telomeres length testing by-mail and longevity genotyping. Custom longevity R&D and telomere protocols, bulk orders.

Read more