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Category: life extension – Page 611

People have been hunting down the legendary fountain of youth since antiquity. Does it exist? Could it ever, even theoretically, exist? A Russian scientist named Dr. Anatoli Brouchkov believes it’s out there, and he thinks he found it in 3.5-million-year-old bacteria. So what does Dr. Brouchkov do next? Inject himself with it, of course.

The bacteria, Bacillus F, was discovered in Siberia in 2009. The bacteria was at once impressive because, despite being roughly 3.5 million years old, it was alive in Siberian permafrost. Brouchkov believes there is a mechanism in this bacteria that allowed it to stay alive in the frost for millions of years. Hey, if bacteria can do it, so can we, right? Who knows, but Dr. Brouchkov was eager enough to experiment with that thought to inject himself with the stuff. Though it’s hard to say if the bacteria “worked” to make the scientist immortal, Dr. Brouchkov claimed in 2015 that he’s feeling better than ever. Only time will tell the rest of his story… Hear more about the unbelievable tale in the video below.

Has he found the fountain of youth?

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Further criticism of the Nature article from Wednesday that suggested there was a limit to lifespan.

We’ve known there is a ‘natural’ maximal human life span for a while, but it would be extraordinarily naive to believe it will always be so

In the latest study published in Nature, researchers claim that human life span has a fundamental limit of around 115. This has been widely publicised around various news platforms, and has proved highly controversial, with many taking sides or making rather grandiose claims about future trajectories. After observing trends in survival from 1900 onwards, the team discovered that maximal life span has plateaued; forming a ceiling at around 115–120 years. Jeanne Calment is so far the longest lived (verified) person in history, passing away at an extensive 122 years. Despite dying in 1997, no one has surpassed her title in over 10 years. The research repeats previous observations and analysis suggesting that without intervention there is indeed a limit to human life span, and that it is exceedingly rare to approach this limit at all; explaining why Calment remains unchallenged.

“It is disheartening how many times the same mistake can be made in science and published in respectable journals” — James W. Vaupel, the director of the Max-Planck Odense Center on the Biodemography of Aging

Continue reading “Life Span Is Only Limited Without Intervention” | >

A great new biomarker for senescent cells is available and will allow researchers to more measure levels of aged cells easier and faster. Great news for gerontologists wishing to demonstrate changes to aged cell populations after therapies.

Scientists have discovered a new way to look for ageing cells across a wide range of biological materials; the new method will boost understanding of cellular development and ageing as well as the causes of diverse diseases.

Frustrated by the limitations of commercially available biomarkers — researchers led by The University of Manchester’s Professor Paul Townsend and senior author of the resulting paper, and honorary professor at Manchester, Professor Vassilis Gorgoulis, have developed a universally applicable method to assess senescence across biomedicine, from cancer research to gerontology.

Cellular senescence is a fundamental biological process involved in every day embryonic and adult life, both good – for normal human development – and, more importantly to researchers, dangerous by triggering disease conditions. Up to now available senescence detecting biomarkers have very limited and burdensome application. Therefore, a more effective, precise and easy-to-use biomarker would have considerable benefits for research and clinical practice.

Continue reading “New method to detect ageing cells – and aid rejuvenation therapies — developed” | >

Rapamycin could lead to the development of drugs to delay some aspects of aging in particular the immune systems decline with age.

Nearly a decade of research showing that Rapamycin makes mice live up to 60% longer, scientists are trying it out as an anti-aging drug in dogs and humans.

Researchers at the University of Washington’s Dog Aging Project gave rapamycin to 16 dogs and imaged their hearts.

“It started to function better. It started to look like a more youthful heart,” said Matt Kaeberlein, co-director of the Dog Aging Project, who has presented this research at conferences but hasn’t yet published it.

Continue reading “Side Effects of Antiaging drug Rapamycin can be managed with lower doses and appears to improve the immune system, restore vitality and delay heart disease and dementia” | >

Circa News, a millennial site, did a story on transhumanism and my campaign. There are 3 videos embedded into this article (a general one on transhumanism, one on using tech to help the environment, and one on a Universal Basic Income):

WATCH | Zoltan Istvan thinks all sentient beings — including, but not limited to humans, artificial intelligence and cyborgs — have the right to be immortal. And that right should be protected under law.

Which is why, naturally, he decided to run for president of the United States.

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In Brief.

  • New research concludes that human lifespan has already reached its peak of 125 years.
  • The research does not take into account synthetic biology and advancements in biotech that could extend lifespans further.

Scientists at the Albert Einstein College of Medicine assert that they have discovered the maximum lifespan of human beings, and it’s a range we may no longer be able to exceed. Dr. Jan Vijg, professor of ophthalmology and visual sciences at Einstein, lead the research, which was published online today in the journal Nature.

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Scientific progress is being held back by established experts who lack ambition and vision.

The mainstream of aging research, at least in public, is characterized by a profound lack of ambition when it comes to treating aging as a medical condition. Researchers talk about slightly altering the trajectory of aging as though that is the absolute most that is possible, the summit of the mountain, and are in many cases ambivalent when it comes to advocating for even that minimal goal. It is this state of affairs that drove Aubrey de Grey and others into taking up advocacy and research, given that there are clear paths ahead to rejuvenation, not just a slight slowing of aging, but halting and reversing the causes of aging. Arguably embracing rejuvenation research programs would in addition cost less and take a much shorter span of time to produce results, since these programs are far more comprehensively mapped out than are efforts to produce drugs to alter the complex operations of metabolism so as to slightly slow the pace at which aging progresses. It is most frustrating to live in a world in which this possibility exists, yet is still a minority concern in the research community. This article is an example of the problem, in which an eminent researcher in the field takes a look at a few recently published books on aging research, and along the way reveals much about his own views on aging as an aspect of the human condition that needs little in the way of a solution. It is a terrible thing that people of this ilk are running the institutes and the funding bodies: this is a field crying out for disruption and revolution in the name of faster progress towards an end to aging.

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Continue reading “An Example of the Glaring Lack of Ambition in Aging Research” | >

Classifying aging as a disease, the debate is hotting up as ICD11 at WHO draws near.

What is considered to be normal and what is considered to be diseased is strongly influenced by historical context (Moody, ). Matters once considered to be diseases are no longer classified as such. For example, when black slaves ran away from plantations they were labeled to suffer from drapetomania and medical treatment was used to try to “cure” them (Reznek, ). Similarly, masturbation was seen as a disease and treated with treatments such as cutting away the clitoris or cauterizing it (Reznek, ). Finally, homosexuality was considered a disease as recently as 1974 (Reznek, ). In addition to the social and cultural influence on disease definition, new scientific and medical discoveries lead to the revision of what is a disease and what is not (Butler, ). For example, fever was once seen as a disease in its own right but the realization that different underlying causes would lead to the appearance of fever changed its status from disease to symptom (Reznek, ). Conversely, several currently recognized diseases, such as osteoporosis, isolated systolic hypertension, and senile Alzheimer’s disease, were in the past ascribed to normal aging (Izaks and Westendorp, ; Gems, ). Osteoporosis was only officially recognized as a disease in 1994 by the World Health Organization (WHO, ).

Disease is a complex phenomenon and a current definition must consider both a biological and social explanation. The medical definition of disease is any abnormality of bodily structure or function, other than those arising directly from physical injury; the latter, however, may open the way for disease (Marcovitch, ). The disorder has a specific cause and recognizable signs and symptoms, and can affect humans, other animals, and plants (Martin, ). The social aspect of disease is significant when trying to divide a line between a healthy and a pathological state. This is a highly context and value driven process and, considering the WHO definition of health as a “state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity,” it is not as simple as classifying disease as the opposite of health (WHO, ). “Someone starving to death is not taken to have a disease, but is still not considered healthy” (Reznek, ).

Continue reading “It is time to classify biological aging as a disease” | >