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For every month in space, astronauts can lose 2.5 percent of their bone density. This is quite troublesome, as it will likely compound with the natural process of aging that also reduces bone density. However, a new therapy could be a fantastic solution to this issue, along with many other bone-weakening conditions.

Researchers from University College London have discovered that stem cells found in human amniotic fluid could be used in a treatment to strengthen brittle bones. The research, published in Scientific Reports, shows the treatment resulted in 79 percent fewer fractures in mice with brittle bone disease. Out of a total 324 mice, 168 were treated, while 156 served as the control group. Eight weeks after the mice were treated both the test group and the control group were evaluated for fractures.

Every control mouse exhibited fractures. Conversely, fractures in the experimental group decreased between 69 and 89 percent, leading to the 79 percent decrease in the fracture rate across all tested bones. Pascale Guillot, the study leader, found that the treatment was not resulting in new bone formation, but instead helping to fortify existing bone tissue.

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The rapid development of so-called NBIC technologies – nanotechnology, biotechnology, information technology and cognitive science – are giving rise to possibilities that have long been the domain of science fiction. Disease, ageing and even death are all human realities that these technologies seek to end.

They may enable us to enjoy greater “morphological freedom” – we could take on new forms through prosthetics or . Or advance our cognitive capacities. We could use brain-computer interfaces to link us to advanced artificial intelligence (AI).

Nanobots could roam our bloodstream to monitor our health and enhance our emotional propensities for joy, love or other emotions. Advances in one area often raise new possibilities in others, and this “convergence” may bring about radical changes to our world in the near-future.

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O n a recent evening at a start-up hub in Spitalfields, London, journalist and author Jamie Bartlett spoke to a small group of mostly under 40, mainly techie or creative professionals about his book Radicals: Outsiders Changing the World. The book, which Bartlett started to research in 2014, before Brexit and Trump, chronicles his time with a series of different radical groups, from the Psychedelic Society — who advocate the “careful use of psychedelics as a tool for awakening to the unity and interconnectedness of all things” — to Tommy Robinson, co-founder of the unabashedly far-right English Defence League, to the founder of Liberland, a libertarian nation on unclaimed land on the Serbian/Croatian border, to Zoltan Istvan, who ran as US transhumanist presidential candidate on a platform of putting an end to death. He campaigned by racing around America in a superannuated RV which he’d modified to look like a giant coffin, dubbed “the Immortality Bus.” His efforts were in vain, and illegal, as it turned out: his campaign was in breach of the US’ Federal Electoral Commission rules.

Bartlett’s book has been damned with faint praise — he has been called “surprisingly naive about politics,” and defining ‘radical’ so broadly as to make the term “meaningless.” The general consensus goes that Bartlett’s journey through the farthest-flung fringes of politics and society is entertaining and impressively dispassionate, but not altogether successful in making a clear or convincing case for radicals or radicalism. But at the talk that night Bartlett challenged what he sees as the complacent acceptance and defense of our current political and governmental systems, institutions and ideas, of the kind of technocratic centrism that prevailed throughout the global North until very recently. Perhaps they need some radical rethinking. Many of the radicals Bartlett spent time with may be flawed, crazy or wrong — literally, legally and morally — but they can also hold up mirrors and magnifying glasses to political and social trends. And sometimes, they can prophesize them…

Bartlett began the evening by saying, “If democracy were a business, it would be bankrupt.” A provocative statement, but one that he backs up. He pointed to research showing that only 30% of those born after 1980 believe that it is essential to live in a democracy. That rate drops steadily with age. A closer look at the research around peoples’ attitudes reveals widespread skepticism towards liberal institutions and a growing disaffection with political parties. Freedom House’s annual report for 2016 shows that as faith in democracy has declined so too have global freedoms — 2016 marks the “11th consecutive year of decline in global freedom.” While a lot of attention has been given to violent polarization, populism and nationalism rising out of anger at demographic and economic changes, Bartlett suggests that perhaps comfort and complacency are culprits too, and he is not the only one: only last week Financial Times columnist Janan Ganesh took up a similar theme.

What are the fringe ideas of today that might become ideas of the future? We cannot, of course, say, but Bartlett’s point is we should be paying much closer attention to the crazed hinterlands of human thought. In 2015 transhumanist Zoltan Istvan was talking about using technology to fundamentally change what it is to be human — to augment our fleshy bodies with steel and silicon. One of Istvan’s favored refrains is the transformative effect of artificial intelligence on the way that we work, and the way that we live. In the past six months, it has become near-impossible to read a newspaper or a magazine without stumbling across a take on how AI is set to change our economy. Istvan’s other hobby-horse is immortality, and using technology to drastically expand the human lifespan — ultimately to the point where it increases so fast that time can’t catch up with us and we reach a kind of “escape velocity.

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Eric Shuss, Ed Hudgins, Peter Voss, Zoltan Istvan, Gennady Stolyarov; Michael Shermer (mod) discuss artificial intelligence and robots. Will these developments lead the economy of the future or end capitalism as we know it?

Gennady Stolyarov II, FSA, ACAS, MAAA, CPCU, ARe, ARC, API, AIS, AIE, AIAF, is the second Chairman in the history of the U.S. Transhumanist Party and the Chief Executive of the Nevada Transhumanist Party. Mr. Stolyarov is an actuary, independent philosophical essayist, science-fiction novelist, poet, amateur mathematician, composer, and Editor-in-Chief of The Rational Argumentator, a magazine championing the principles of reason, rights, and progress. Mr. Stolyarov regularly produces YouTube videos discussing life extension, libertarianism, and related subjects, In December 2013, Mr. Stolyarov published Death is Wrong, an ambitious children’s book on life extension illustrated by his wife Wendy Stolyarov. Death is Wrong can be found on Amazon in paperback and Kindle formats, and can also be freely downloaded in PDF format in the English, Russian, French, Spanish, and Portuguese languages.

Dr. Edward Hudgins is research director at the Heartland Institute, which seeks to develop and promote free-market solutions to social and economic problems. Hudgins has written extensively on the promise of exponential technologies and the need for a human achievement and entrepreneurial ethos. Before joining Heartland, he worked at The Atlas Society, which promotes the philosophy of reason, freedom, and individualism developed by Ayn Rand. During his stint at the Cato Institute, Hudgins directed regulatory studies and produced the book, Space: The Free-Market Frontier. He has also worked at the Joint Economic Committee of Congress and at The Heritage Foundation, where he pioneered the concept of an Index of Economic Freedom. Hudgins has a BA from the University of Maryland, an MA from American University, and a PhD from the Catholic University of America. He has taught at universities both in the United States and Germany.

Zoltan Istvan is a Libertarian candidate for California Governor in 2018. He is often considered one the world’s leading transhumanists after his popular run in the 2016 US Presidential race as a science and technology candidate. Zoltan began his futurist career by publishing The Transhumanist Wager, an award-winning, #bestseller in philosophy that has been compared to Ayn Rand’s work. Zoltan is also a leading technology journalist, a successful entrepreneur, and a former filmmaker and on-camera reporter for the National Geographic Channel. His futurist work and promotion of radical science has reached over 100 million people. He is a graduate of Columbia University, and lives in San Francisco with his physician wife and two young daughters. Breitbart wrote, “Istvan is a dynamic personality, as polarizing as he is engaging.” The New York Times wrote Zoltan has “a plausibly presidential aura.”

Eric Shuss has been actively involved in managing and acquiring high-tech companies for over thirty five years. He has owned and managed successful companies from start-up to thriving, ongoing ventures including professional services consulting firms, high-tech manufacturers and AI and computer software companies. He has extensive international business management experience with a keen understanding of how technology impacts today’s business. He is an author and futurist who serves on several advisory boards. He has worked in mid-to-large companies in roles of Senior Industry Analyst, Managing Consultant, Director of Information Systems, Director of Operations, Vice President, President, COO and CEO. His in-depth knowledge of multiple industries and complex business processes allows him to look at the big picture. He understands that technology alone is not the answer, but is a key component to success.

Filmed by Ford Fischer.

A research team led by Dr. Cai at the Albert Einstein college of medicine have shown that stem cells in the hypothalamus influence how fast we age. The new research, shown in mice, may lead to approaches that delay or even prevent age-related diseases[1].

Unfortunately like 70% of scientific research, this publication is behind a paywall, so those wishing to read will have to use the usual channels to obtain the publication. We discuss why paywalls are an unacceptable barrier to progress here in our interview with Sci-Hub.

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Imagine a world in which you’re 90 years old and nowhere near middle-aged. An app on your phone has hacked your DNA code, so you know exactly when to go to the doctor to receive gene therapy to prevent all the diseases you don’t yet have. A microchip in your skin sends out a signal if you’re at risk of developing a wrinkle — so you step out of the sun and hotfoot it to your dermatologist. Every evening you sync your brain-mapping device with The Cloud, so even if you were caught up in a fatal accident you’d still be able to cheat death — every detail of your life would simply be downloaded to one of the perfect silicon versions you’d had made of yourself, ensuring you last until at least your 1,000th birthday.

This may sound like science fiction but it could be your fate — provided you can afford it. If current research develops into medicine, in the London of the future the super-rich won’t simply be able to buy the best things in life, they’ll be able to buy life itself by transforming themselves into a bio-engineered super-race, capable of living, if not forever, then for vastly longer than the current UK life expectancy of 81 years.

The science of turning back the clock has never been more advanced. In Boston, a drug capable of reversing half a lifetime of ageing in mice is about to be tested on humans in a medical trial monitored by NASA. NMN is a compound found naturally in broccoli which boosts levels of NAD, a protein involved in energy production that depletes as we get older. Professor David Sinclair, who headed up the initial research at Australia’s University of New South Wales, doses himself with 500mg daily, and claims that he has already become more youthful. According to blood tests analysing the state of the 48-year-old’s cells, prior to taking the pills Sinclair was in the same physical shape as a 57-year-old, but now he’s ‘31.4’.

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Scientists at Albert Einstein College of Medicine have found that stem cells in the brain’s hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan. The paper was published online today in Nature.

The was known to regulate important processes including growth, development, reproduction and metabolism. In a 2013 Nature paper, Einstein researchers made the surprising finding that the hypothalamus also regulates aging throughout the body. Now, the scientists have pinpointed the in the hypothalamus that control aging: a tiny population of adult , which were known to be responsible for forming new brain neurons.

“Our research shows that the number of hypothalamic neural stem cells naturally declines over the life of the animal, and this decline accelerates aging,” says senior author Dongsheng Cai, M.D., Ph.D., (professor of molecular pharmacology at Einstein. “But we also found that the effects of this loss are not irreversible. By replenishing these stem cells or the molecules they produce, it’s possible to slow and even reverse various aspects of aging throughout the body.”

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What if there was one thing that you could do today to delay or improve the natural aging process in your body and mind?

At Emerge we are constantly seeking collaboration with the best minds in the world for helpful and practical advice on how to stay physically, mentally and financially healthy. Today we explore the concept of what it would be like to totally reimagine aging.

We’ve spent weeks rounding-up the top experts from around the world in various aging (also referred to as senescence) fields and asked them one question for our highly health conscious audience:

What is the best habit for staying physically or mentally young that most people do not know?

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