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The concept of repairing age-related damage to prevent diseases is now mainstream and openly talked about by most acadmics.


Earlier this year the second Scripps Florida Symposium was held and now this open access paper reports on the event. The title of of the event was ‘Advances in Therapeutic Approaches to Extend Healthspan’ and was held on January 22nd–25th, 2017 at The Scripps Research Institute in Jupiter, Florida.

It is once again very refreshing to see that the focus of the researchers here is now firmly on intervening on the various aging processes in order to prevent or treat age-related diseases. Less than a decade ago suggesting addressing the aging processes to treat disease as a preventative form of medicine would have jepordised the chances of funding, or even damaged a researcher’s career prospects. Now the majority of researchers are engaged in exploring the potential of increasing healthspan (the period of life spent free of age-related disease) with the aim of delaying or preventing age-related diseases.

The taboo of talking about doing something about aging

Whilst there is still resistance in academia to talk in public about the potential of these therapies leading to not only healthier but also longer lives, it is nonetheless a step in the right direction. The discussion has changed dramatically in the last decade and the taboo of targeting the aging process has largely been banished, this in our view is a good thing. Only the most conservative scientists cling to the idea that nothing can be done about aging despite the mountains of evidence suggesting otherwise.

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We teamed up the MMTP last week and did a special longevity live panel on Facebook with Dr. Aubrey de Grey, Dr. Alexandra Stolzing, Dr. Oliver Medvedik and guests. Check it out.


We teamed up with the MMTP for their “How to Promote Longevity?” Live Panel. Dr. Aubrey de Grey, Dr. Alexandra Stolzing and Dr. Oliver Medvedik and guests discuss the latest research and progess in rejuvenation biotechnology.

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Liz Parish joins the show to discuss her company’s efforts to reverse aging. Her aging trials have been famously conducted on her personally resulting in 20 year reversals on Telomere cell lengths, muscle mass, and other factors. We discuss the real possibility that humans could live to be over 1000 years old in our lifetimes. We also discuss the ethical issues that arise from the flood of new technologies that will soon be on the market.

You can see more about Parrish and her company at BioViva-Science.com

See more episodes and articles at www.SarahWestall.com

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Interview with Dr. Jose Luis Cordeiro at the International Longevity and Cryopreservation Summit in Madrid.


During the recent International Longevity and Cryopreservation Summit in Madrid, LEAF Board member Elena Milova had the opportunity to speak with Dr. Jose Luis Cordeiro new fellow of the World Academy of Art and Science (WAAS) and long-term proponent of innovation technologies in many fields. Jose shared his vision on how public perception of rejuvenation technologies is changing over time and what are the main outcomes of the groundbreaking show he and his team managed to organize.

Dr. Cordeiro got his B.Sc. and M.Sc. degrees in Mechanical Engineering at the Massachusetts Institute of Technology (MIT) in Cambridge, USA, with a minor in Economics and Languages. He is President Emeritus of the Future World Society (Venezuela) and since its foundation about two decades ago Jose managed to become an influential futurist. He is a founding faculty at NASA created Singularity University in Silicon Valley. The goal of the research centre is to tackle global problems such as health, nutrition, poverty and education using the medium of technology. He is also on the board of directors for the Lifeboat Foundation. Jose is part of Fundacion VidaPlus, promoting rejuvenation technologies as well as cryonics, as he believes that people who are too old to make use of the emerging biotechnologies should be granted a plan B in form of cryopreservation. Apart from traveling all over the world to promote innovative ideas in his inspiring talks, Jose has written more than 10 books and co-written over 20 more in five languages, including sections of the State of the Future by the Millennium Project. His extensive associations and achievements are far too numerous to list in this short article, and we invite you to read more about Jose here and also watch his awesome TEDx talk here.

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Increasing autophagy in macrophages is a promising avenue of research aiming at heart disease and other age-related diseaeses.


Today we thought it was a good time to take a look at a new study that demonstrates that increasing autophagy is a good approach to slowing aging and could be the foundation for a variety of therapies to treat age-related diseases.

What is Autophagy?

Autophagy is an intracellular degradation system that delivers unwanted cell components to a type of cellular garbage disposal system, known as the lysosome. The lysosome uses powerful enzymes that break down the unwanted material for recycling. However, as we age the lysosomes become clogged up with materials that are so fused together not even the potent enzymes can destroy them and this causes the lysosomes to become dysfunctional and eventually the cell dies. This is a particular problem for long lived cells with a very low rate of replacement such as the heart, the back of the eye, nerve cells and other cells that rarely divide if at all. Ultimately as more and more cells become dysfunctional over time due to lysosome dysfunction, tissue function become impaired and age-related disease sets in.

Due technical issues the Longevity Panel with Aubrey de Grey, Alexandra Stolzing and Oliver Medvedik + guests will be airing on Friday 9th June at 13:00 on the MMTP Facebook page. Apologies for the delay.


We are teaming up with LEAF/Lifespan.io for our Longevity Panel with Dr. Alexandra Stolzing, Dr. Aubrey de Grey, Dr. Oliver Medvedik and a number of other guests. We will be streaming the panel live to this page and we invite you to join us. It will also be made available later to view on Youtube.

This was originally scheduled for the 6th June but had to be rescheduled due to technical problems. We apologize for the inconvenience.

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A brief article I wrote to rebut the misconception that longer—perhaps indefinite—lifespans would cause eternal boredom.


Alright. So, some people object you don’t want a very long lifespan because it would end up being boring. Even if a currently normal lifespan wasn’t enough, they argue, something like two hundred years would be more than enough to do anything worth doing. I wouldn’t bet my last cent on it.

Meet John and Jack, both born in the year 1400. John says he regrets he will not live past 1500 1490 1470 (that’s more like it). There are so many things he’ll miss out on centuries from now, he says.

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Japanese researchers have identified specific features of a gene that could hold the key to living beyond 100 and lead to the development of medicine for extra longevity.

Scientists at the Tokyo Metropolitan Institute of Gerontology, Keio University and other institutes said that centenarians and those close to that age share specific features of a gene that helps stem the spread of cancer and form bones.

“The gene we identified recently is not the sole actor determining longevity,” said Masashi Tanaka, chief of the Department of Clinical Laboratory at the institute. “But we believe that it plays a role in anti-aging in one way or another.”

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Only one more day to go before the live longevity panel with Dr. Aubrey de Grey, Dr. Alexandra Stolzing and Dr. Oliver Medvedik plus guests!


June 6th at 13:00 EST/18:00 UK we are teaming up with LEAF/Lifespan.io for a special Longevity Panel featuring Dr. Alexandra Stolzing, Dr. Aubrey de Grey, Dr. Oliver Medvedik and guests.

We will be streaming the panel live to this page and we invite you to join us. It will also be made available later to view on Youtube.

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