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Alzheimers Drug Turns Back the Clock in Mitochondria

J147 is an experimental drug that has been shown to treat Alzheimer’s disease, and it also appears to reverse some aspects of aging. It is also poised to enter human clinical trials in the near future, although how it works has been somewhat of a puzzle.

A new study published in the journal Aging Cell has changed all that, and the results are quite intriguing[1]. Researchers at the Salk Institute have solved the mystery of how J147 works and why it makes old flies, mice, and cells more youthful.

Exercise is Currently the Best Way to Slow Down Aging

We have all heard that exercise is good for our health. However, it can not only keep you healthy, it can also slow down some aspects of aging. Some researchers even think that it might be possible to use this knowledge to develop new therapies against aging. While waiting for that to happen, we need to exercise in order to slow down the effects of aging.

How important is it to keep fit?

So, how beneficial is exercising? Well, one of the best studies conducted on this subject showed that women will live 5.6 years longer and men 6.2 years longer if they exercise between 1 and 2.5 hours per week[1]. This makes exercise a better lifestyle choice than any other, at least as long as you’re not counting avoiding downright dangerous behavior, such as smoking.

Discussion of iTR Publication

AgeX, one of our supported startups aiming at turning basic research into actual rejuvenation therapies for human application, just published a breakthrough genetic discovery that could enable us to activate tissue regeneration capabilities in humans.

Dr. Mike West, CEO of AgeX, will also be presenting at undoing-aging.org

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#foreverhealthy #undoingaging

Understanding Why the Thymus Shrinks With Age

Today, we are going to take a look at a new study in which scientists at the Walter and Eliza Hall Institute of Medical Research have recently identified a type of cell that appears to be implied in thymic involution—the shrinking of the thymus[1].

Thymic involution is somewhat of a mystery in biology, a phenomenon that isn’t fully understood that happens to everyone with age and is a driving cause of immunosenescence, the age-related decline in our immune systems’ ability to fight disease. This new study helps to shed light on why it happens.

A crowdfunding platform aims to solve the puzzle of aging

Dr. Oliver Medvedik Vice President of LEAF appears in this new TED interview where he talks about aging research and the possibilities of future medicine.


Aging happens to all of us, but scientists still don’t know the mechanism behind it. We need to focus on finding an answer, says molecular biologist Oliver Medvedik.

If given the option, would you choose to live forever? Many of us would say “yes,” but with one major caveat: just as long we don’t age. In scientific terms, aging means “a progressive loss of fitness in an organism over time,” says molecular biologist and TED Fellow Oliver Medvedik. What causes this loss of fitness in humans is multifaceted, although scientists are exploring different theories including — and these are just a few of the many avenues of research — the deterioration of the health of our telomeres (the ends of our chromosomes), changes in cell mitochondria, inefficient clearance of damaged cell proteins, and the senescence of stem cells, leading to chronic inflammation and a depletion of stem cells.

Although it causes a loss of fitness and health, aging is not seen as a disease. “The FDA defines a disease as something that afflicts only a segment of the population. But aging affects everyone,” says Medvedik, the co-founder of Genspace, a citizen science biotech lab, and a professor of bioengineering at the Cooper Union in New York City. And because aging is not considered a disease by the government, it limits the amount of federal funding available in order to study it.

Top Five Deadly Vitamins

A look back at the most popular health articles of 2017. Here is the report: “Top Five Deadly Vitamins”


Summary: High-dose vitamin and mineral supplements were once promoted as ways to prevent heart disease, aging, and cancer. To the contrary, recent research has shown that excessive vitamin and mineral consumption sometimes shortens life. Using evidence from scores of clinical trials we generate a list of five vitamin and mineral supplements that have been shown to be harmful to an otherwise healthy person when consumed in excess. [Note: This article was extensively updated on Nov 2, 2017]. This article first appeared on LongevityFacts.com. Follow us on Google+ | Facebook | Reddit. Author: Brady Hartman.

Recent research shows that some vitamin or mineral supplements are hazardous to your health.

In particular, five vitamin and mineral supplements have been shown to be harmful to an otherwise healthy person when consumed in supranormal doses.