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Category: life extension – Page 562

There is a growing list of aging biomarkers available to researchers that help them measure how well someone is aging and assess how aging interventions are working in preclinical testing.

Some clinical biomarkers, such as DNA methylation and telomere length, are commonly used in labs. Other biomarkers, such as blood pressure, grip strength, heart rate variability, visual reaction time, and decision reaction time, are non-invasive and easy to test.

Currently, DNA methylation is generally regarded as the gold standard for aging biomarkers, although new techniques, such as cell functional age, are attempting to challenge that. The sensible choice, of course, would be to combine both methods to further improve the accuracy of results.

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A new interview I did on my transhumanist California Governor run:

On August 4th, Zoltan Istvan joined Merion West’s Erich Prince for an interview to discuss his campaign for Governor of California. Running in this race as a Libertarian, Mr. Istvan previously ran in the 2016 presidential election as a member of the Transhumanist Party. Working previously for National Geographic, Mr. Istvan is well-known for his writings on transhumanism, the movement that aims to improve human life and extend longevity through science. A pillar of his campaign for Governor of California includes a proposal for implementing universal basic income.

Erich Prince: Mr. Istvan, thank you for joining us this morning. Could you start by explaining the connection that you see between transhumanism, the movement you’re so involved with, and libertarianism?

Zoltan Istvan : The transhumanism and libertarian movement are connected through this concept called Morphological freedom. Morphological freedom is the idea that you should be able to do anything with your body that you want to do, as long as it doesn’t hurt someone else. It’s a core transhumanist concept. Of course, it’s also a core libertarian concept. It’s the idea that your body belongs to you; it’s part of the non-aggression principle, and because of that single issue, transhumanism and libertarianism have always been connected. As a result, when the movement first began, it was very libertarian-oriented, and I still find it very libertarian-oriented, especially when it comes to government staying out of the way of people wanting to do science and not face interference.

Continue reading “Merion West Interviews Zoltan Istvan, Candidate for Governor of CA” | >

Unprecedented acute concentration of wealth happens alongside these expulsions. Advanced economic and technical achievements enable this wealth and the expulsion of surplus groups. At the same time, Sassen writes, they create a kind of nebulous centerlessness as the locus of power:

The oppressed have often risen against their masters. But today the oppressed have mostly been expelled and survive a great distance from their oppressors … The “oppressor” is increasingly a complex system that combines persons, networks, and machines with no obvious centre.

Surplus populations removed from the productive aspects of the social world may rapidly increase in the near future as improvements in AI and robotics potentially result in significant automation unemployment. Large swaths of society may become productively and economically redundant. For historian Yuval Noah Harari “the most important question in 21st-century economics may well be: what should we do with all the superfluous people?”

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As we age the brain loses its flexibility, this in turn affects our ability to learn, to remember things and adapt to new situations. The classic theme is of an older person who is stuck in a rut and unable to change how they think.

This is also a common concern people raise when any discussion of healthy longer lives are mentioned. The concern is that we would have a world of people living more decades and becoming so set in their ways that society would stagnate.

However, many proponents of rejuvenation biotechnology refute this and suggest that mental plasticity could be rejuvenated just the same as cells and tissues could be. The new study we will discuss today offers us a hint of what might be possible, although the focus here is specifically on the visual cortex[1].

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Aging. We all face it. Nobody’s immune and we’ve long tried to reverse it, stop it or just even slow it down. While advances have been made, true age-reversal at a cellular level remains difficult to achieve. By taking a different approach, however, researchers at Houston Methodist made a surprising discovery leading to the development of technology with the ability to rejuvenate human cells. And that couldn’t be more important for the small population of children who are aging too quickly — children with progeria.

John P. Cooke, M.D., Ph.D., department chair of cardiovascular sciences at Houston Methodist Research Institute, and his colleagues, describe their findings in a Research Letter titled “Telomerase mRNA Reverses Senescence in Progeria Cells,” appearing online July 31 and in print Aug. 8 in the Journal of the American College of Cardiology, a leading medical journal in the field of cardiovascular disease.

Cooke studied cells from children with , a rare condition marked by rapid aging that usually robs them of the chance to live beyond their early teens. They focused on progeria, because the condition tells them a lot about aging in general that’s ultimately relevant to all of us.

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Cellular senescence is widely considered by academia to be one of the causes of aging and one that leads to a number of age-related diseases. There has been a high level of interest in recent years in cellular senescence and approaches that seek to remove senescent cells as a route to delaying or even preventing age-related diseases.

Today we have a new study where researchers focus on pulmonary fibrosis and the role of cellular senescence.

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Transhumanists are curiosity addicts. If it’s new, different, untouched, or even despised, we’re probably interested in it. If it involves a revolution or a possible paradigm shift in human experience, you have our full attention. We are obsessed with the mysteries of existence, and we spend our time using the scientific method to explore anything we can find about the evolving universe and our tiny place in it.

Obsessive curiosity is a strange bedfellow. It stems from a profound sense of wanting something better in life—of not being satisfied. It makes one search, ponder, and strive for just about everything and anything that might improve existence. In the 21st century, that leads one right into transhumanism. That’s where I’ve landed right now: A journalist and activist in the transhumanist movement. I’m also currently a Libertarian candidate for California Governor. I advocate for science and tech-themed policies that give everyone the opportunity to live indefinitely in perfect health and freedom.

Politics aside, transhumanism is the international movement of using science and technology to radically change the human being and experience. Its primary goal is to deliver and embrace a utopian techno-optimistic world—a world that consists of biohackers, cyborgists, roboticists, life extension advocates, cryonicists, Singularitarians, and other science-devoted people.

Transhumanism was formally started in 1980’s by philosophers in California. For decades it remained low key, mostly discussed in science fiction novels and unknown academic conferences. Lately, however, transhumanism seems to be surging in popularity. What once was a smallish band of fringe people discussing how science and technology can solve all humanity’s problems has now become a burgeoning social mission of millions around the planet.

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News from Veritas and remember Veritas are offering a whole genome sequence as one of the rewards in our AgeMeter campaign at Lifespan.io:

https://www.lifespan.io/campaigns/agemeter-biomarker-scan/#reward_12

“On August 3, sequencing company Veritas Genetics bought one of the most influential: seven-year old Curoverse. Veritas thinks AI will help interpret the genetic risk of certain diseases and scour the ever-growing databases of genomic, medical, and scientific research.”

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