Lifeboat Foundation

https://www.youtube.com/watch?v=3CT5IiLDnAY

There’s a quick line in here about how in the 70’s they took a look at the complexity of metabolism and decided no one would ever figure out how to solve aging. Might have been nice to have an Aubrey or a Parrish or an Andrews at the time to get started then.

Aubrey De Grey, Chief Science Officer for the SENS Research Foundation talks living forever young at London’s GIANT 2016 event. For more on Aubrey De Grey and gerontology: http://www.healthgauge.com/read/life-extension/

While it used to be the stuff of science fiction, the technology behind the dream has advanced in recent years.

As the year moves on and we look back at the achievements this year we would be remiss to not mention the fantastic result we got for the OncoSENS fundraiser hosted on Lifespan.io. We raised an amazing $72,002 for ALT cancer research thanks to the amazing supporters we have. Thank you to everyone who helped and donated to OncoSENS to make it another victory for SENS Research and for Science!

#aging #sens

Scientists have discovered a new way to edit DNA that could fix “broken genes” in the brain, cure previously incurable diseases and potentially even extend the human lifespan.

The breakthrough – described as a “holy grail” of genetics – was used to partially restore the sight of rats blinded by a condition which also affects humans.

Previously researchers were not able to make changes to DNA in eye, brain, heart and liver tissues.

Continue reading “DNA-editing breakthrough could fix ‘broken genes’ in the brain, delay ageing and cure incurable diseases” »

Great to see more quality aging biomarkers arriving for researchers. Well done to Alex Zhavoronkov and his team for this brilliant work.

Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification.

More news about SENS Research Foundation fundraiser and a look back at some of the achievements so far.

#sens #aging

Good news! Thanks to the generous pledges of new SENS Patrons, signing up for monthly donations to the SENS Research Foundation over the past two weeks since the fundraiser started, the $24,000 matching fund put up by Josh Triplett and Fight Aging! is nearly met. Just a little more left to reach the target: if you are the next person to sign up, the next year of your donations to the SENS Research Foundation will be matched dollar for dollar. But if you miss out on that, donations made before the end of the year can still be matched. The Forever Healthy Foundation’s Michael Greve, who earlier this year pledged $10 million to SENS rejuvenation research and startup companies building rejuvenation therapies, has put up a further $150,000 challenge fund. He will match all donations to the SENS Research Foundation made before the end of 2016, and there is still a way to go in order to meet that target. So help us get this done!

Continue reading “Forever Healthy Foundation Provides a $150,000 Challenge Fund to Match SENS Rejuvenation Research Donations” »

New hope for age related macular degeneration.

The discovery of a novel protein that links aging and age-dependent retinal diseases could lead to potential new treatments for conditions that cause sight loss in later life.

In a study in mice, to be published in the journal eLife, researchers from the University of Wisconsin-Madison reveal that Transmembrane 135 (Tmem135) regulates retinal aging, and that mutations in the protein result in age-dependent disease.

Continue reading “New protein provides critical link between aging and age-dependent disease” »

Heart disease prevention measures have made some impact on mortality rates. Looking after your heart is absolutely critical for your longevity plan.

Despite the rising proportion of the older population who choose to be overweight or obese, risk of heart disease has declined somewhat in past few decades. This outcome can be attributed to prevention in the sense of at least some people taking better care of their health by specifically targeting measures such as blood pressure and blood lipid levels, coupled with prevention in the sense of treatments such as statins that also reliably influence these measures. Increased blood pressure with age, or hypertension, directly impacts risk of cardiovascular disease and other conditions by putting additional stress on tissue structures and causing the heart to remodel itself detrimentally. Higher blood lipid levels on the other hand contribute to the progression of atherosclerosis, attacking blood vessel walls to form fatty deposits that can later break to cause blockages or ruptures of blood vessels. These are all things best avoided if possible, but until the advent of rejuvenation therapies after the SENS model the best that can be done is to slow down the damage.

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Continue reading “Measuring the Effects of Prevention on Heart Disease” »

More supporting data that higher education is good for longevity.

National Academy of Sciences.