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Category: life extension – Page 54

A new feature story out on book Transhuman Citizen:

A former presidential candidate who believes a dramatic increase in science funding can help humans achieve biological immortality has told Newsweek he is considering a third White House run in 2028.

Zoltan Istvan ran as an independent candidate during the 2016 presidential election when he attracted widespread media attention for driving a bus modified to look like a coffin from San Francisco to Washington D.C., to illustrate his believe that death can be overcome.

In 2019 he challenged Trump for the Republican presidential nomination using the campaign motto “Upgrading America,” in what he admitted was primarily a stunt to increase conservative interest in his ideas.

Continue reading “Meet the presidential hopeful who wants to end death” | >

So, they get very healthy but only live 24% longer no matter how many more times they use the treatment. I wonder what the telomere effect is. And what they are doing is not the same as what Aubrey’s mouse experiment is doing.

Altos Labs Co-founder and Chief Scientist Rick Klausner participated in a panel discussing efforts to increase human healthspan by combatting age-related diseases at this year’s Aspen Ideas Health conference.

In a panel that included Laura Deming and Kristen Fortney, Klausner discussed an Altos experiment in Spain (likely to be research conducted by Universidad Católica de Murcia and Altos Labs in collaboration with the Hospital Clínic de Barcelona), Klausner reported that if old kidneys are transplanted into young people they do not function nearly as well as transplanting young kidneys – but organ donations donors are getting older and older, and therein lies the rub.

Continue reading “Altos rejuvenation research in mice signposts healthspan extension” | >

The skin’s protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in combination with quercetin (D + Q) on senescent human skin fibroblasts and aging human skin. Senescence was induced in human dermal fibroblasts (HDFs) using approaches such as long-term passaging, ionizing radiation, and doxorubicin treatment. The generated senescent cells were treated with D + Q or vehicle.

Read more | >

New research indicates that plasma fusion heat spreads more evenly in tokamak reactors, suggesting a reduced risk of damage to critical components, thereby improving reactor longevity and efficiency.

According to researchers from the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL), Oak Ridge National Laboratory, and the ITER Organization (ITER), the intense exhaust heat produced by fusing plasma in a commercial-scale reactor might not be as damaging to the reactor’s interior as previously believed.

“This discovery fundamentally changes how we think about the way heat and particles travel between two critically important regions at the edge of a plasma during fusion,” said PPPL Managing Principal Research Physicist Choongseok Chang, who led the team of researchers behind the discovery. A new paper detailing their work was recently published in the journal Nuclear Fusion, following previous publications on the subject.

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Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.

Direct neuronal , a complex procedure that involves changing the function of one type of cell into another, offers a promising strategy.

In cell culture and in living organisms, glial cells—the non-neuronal cells in the central nervous system—have been successfully transformed into functional neurons. However, the processes involved in this reprogramming are complex and require further understanding. This complexity presents a challenge, but also a motivation, for researchers in the field of neuroscience and regenerative medicine.

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The Tesla Model Y has topped Sweden’s automotive registrations regardless of powertrain type in the first half of 2024, as shown in new data.

The Model Y was the most-registered vehicle in Sweden in the first six months of this year, according to data from Mobility Sweden reported by Carup on Monday. The Model Y topped the charts overall with 7,386 units registered, despite a 20 percent decline in overall EV sales. The Model 3 landed 14th overall in the six-month period, while electric options from Volvo, Toyota, Polestar, and Volkswagen were also some of the most registered.

“It is gratifying that the proportion of electric cars reached the best for the year in June, but at the same time we see a stagnant market, which leads to a gradually aging vehicle fleet,” said Mattias Bergman, CEO of Mobility Sweden. “In order to meet the climate goals and strengthen Sweden’s competitiveness, it is crucial that electrification is accelerated.”

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MD Anderson researchers identify molecule that reduces age-related inflammation and improves brain and muscle function in preclinical models.

MD Anderson News Release June 21, 2024

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring…

The study, published today in Cell, identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), which normally is repressed with the onset of aging. Maintenance of TERT levels in aged lab models reduced cellular senescence and tissue inflammation, spurred new neuron formation with improved memory, and enhanced neuromuscular function, which increased strength and coordination.

Continue reading “Activating molecular target reverses multiple hallmarks of aging” | >