Improvements in public health and medicine have lengthened human survival, but science has yet to overcome ageing.
Category: life extension – Page 55
They say aging is just a part of life, but have you ever wondered if it really has to be? What if getting older isn’t just something we accept but something we could actually treat?
In this riveting episode of Peak Human Labs Podcast, Dr. Sanjeev Goel, sits down with Dr. Aubrey de Grey, a trailblazing biomedical gerontologist and Chief Science Officer of the SENS Research Foundation. They dive deep into the revolutionary idea of treating aging as a medical condition. They explore how damage accumulates in our bodies over time and discuss the groundbreaking medical advancements that could extend our healthy lifespans. Dr. de Grey sheds light on the crucial need for investing in underfunded research and shares insights into the future of longevity science. Tune in and envision a future where health and longevity are not just aspirations but achievable realities!
Click https://dublinlongevitydeclaration.or… to sign in for Dublin Longevity Declaration.
In This Episode:
[00:00:00] Introduction to longevity research.
[00:00:51] Guest introduction.
[00:01:17] Personal connection.
[00:02:04] Dr. de Grey’s background.
[00:03:14] Early research stages.
[00:04:05] Understanding aging as a machine.
[00:05:22] Accumulated damage mechanism.
[00:06:15] Comprehensive medical control.
[00:07:13] Categories of damage.
[00:07:55] Wear and tear concept.
[00:09:20] Epigenetic changes discussion.
[00:11:31] Partial reprogramming concept.
[00:13:30] Addressing multiple mechanisms.
[00:14:31] Longevity escape velocity.
[00:15:43] Initial pushback on longevity ideas.
[00:17:51] Positive outlook on aging research.
[00:19:51] The future of longevity research.
[00:20:54] Funding disparities in research.
[00:21:10] Business models in longevity research.
[00:21:58] Combining existing therapies.
[00:23:47] Current longevity therapies.
[00:24:56] Caloric restriction vs. drugs.
[00:25:36] Dublin Longevity Declaration.
[00:26:39] Community building through conferences.
[00:28:09] Anticipating longevity breakthroughs.
[00:29:12] Access to longevity therapies.
[00:30:58] Epigenetic clocks and age reversal.
[00:32:24] Retroviruses and aging.
[00:34:56] Persistent viral infections.
[00:37:24] Hyperbaric oxygen therapy.
[00:37:49] Therapeutic blood exchange.
[00:39:37] Discussion on active ingredients.
[00:40:41] Bone marrow transplant experimentation.
[00:42:09] Health benefits of bone marrow transplants.
[00:43:05] Personal health practices.
[00:43:55] Advice for maximizing healthy lifespan.
[00:45:01] Microbiome and longevity.
Navigating the frontiers of longevity: therapeutic plasma exchange and its implications.
Therapeutic plasma exchange (TPE) has emerged as a contentious longevity treatment, touted for its potential to rejuvenate the body.
In another effort to live longer, wealthy Silicon Valley-ites are ditching young blood for plasma exchange.
Afrolongevity
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My recent Op-Ed: We need integrated approaches to healthy longevity and to our human future. Enjoy my article and work with me to build a community of Human evolution of consciousness with AI.
In vivo DNA replication dynamics in regenerating mouse livers unveil aging-dependent decline in replication efficiency and a crucial role of the ATR checkpoint kinase in mitigating inflammation associated with the decline.
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Billionaires are backing top scientists racing to develop tech that could reverse aging. Cellular reprogramming promises to rejuvenate the body… but how does it work, and is it safe?
00:00 – Introduction.
00:55 – The Role Of Stem Cells.
02:33 – What Is Aging?
03:24 – What Is Cellular Reprogramming?
03:56 – How The Yamanaka Factors Can Rejuvenate Cells.
05:35 – Why Scientists Want To Partially Reprogram Cells.
06:28 – How Humans Could Become More Resilient To Age-Related Diseases.
07:00 – How Johnny Huard Uses Cellular Reprogramming.
08:10 – How Cellular Reprogramming Could Shape The Future.
08:38 – Amazon’s Jeff Bezos Is Investing Billions With Altos Labs.
09:02 – How Harvard Professor David Sinclair Used Cellular Reprogramming on Mice.
10:07 – ChatGPT’s Sam Altman Launched Retro. Biosciences.
10:57 – The Risks of Cellular Reprogramming, Including Cancer.
12:56 – How the Tech World Is Investing In Biotech.
13:50 – Credits.
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Researchers at Duke-NUS Medical School have identified interleukin-11 (IL11) as a key factor in the ageing process. Elevated IL11 levels lead to fat accumulation and muscle loss—two major indicators of ageing. Inhibiting IL11 could enhance healthy lifespans.
Ageing populations pose significant health and economic challenges globally. Even a one-year increase in life expectancy could be valued at $38 trillion.
In a study published in Nature, the team demonstrated that anti-IL11 therapy not only counters the harmful effects of ageing but also increases lifespan by up to 25% in preclinical models. The therapy shifts metabolism from generating harmful white fat to beneficial brown fat, which helps burn calories and maintain body temperature.
Our longevity may actually turn out to have a hard limit. In a new study this week, scientists show that the long rise in our collective life expectancy seen during the 20th century has started to slow down as of late. The findings suggest that focusing on simply expanding our lifespan might be short-sighted, the researchers say.