Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging.

Senescent cells and the SASP

As we get older, an increasing number of our cells enter into a state known as senescence. They cease dividing and supporting the tissues and organs of which they are part and, instead, secrete a range of harmful chemical signals. This cocktail of harmful signals is known as the senescence-associated secretory phenotype (SASP).

Clinical trials to remove senescent cells have now begun.

undoing-aging.org/…/judy-campisi-presenting-at-undoing-agin…

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The findings, published in the journal Nature Medicine, showcase a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome. This treatment provides an important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via gene therapy. The researchers hope to translate this therapy to humans to potentially provide a cure for progeria as well as possibly slowing down the aging process to delay the onset of age-related diseases in everyone.

Link to paper: https://www.nature.com/articles/s41591-019-0343-4

Abstract.