Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 486

We brought the leading experts in aging research and biotech investment together for an action-packed day of science. See what happened at this exciting event and check out our first event video now.

On July 12th, we hosted our first conference, Ending Age-Related Diseases: Investment Prospects & Advances in Research, at the Frederick P. Rose Auditorium, which is part of the Cooper Union campus in New York City. We are delighted to announce that the conference was a huge success with 160 attendees, a wide variety of speakers from both research and business, and some great discussion panels.

The goal of this conference was to promote multidisciplinary collaboration in order to foster the development of next-generation drugs and therapies that directly target the processes of aging and thus have the potential to prevent and cure age-related diseases.

Continue reading “Celebrating Success at Our First Conference” | >

The brain is about 10% neurons and 90% neural network support cells, called neuroglia, or glial cells, which surround and insulate neurons, protect them from damage, and supply them with nutrients and oxygen. Neuroglia are often found to malfunction in neurological disorders such as Alzheimer’s Disease or amyotrophic lateral sclerosis (ALS).

Research studies indicate that telomerase gene therapy may not only reverse Alzheimer’s Disease and other dementias, but it may even protect people from developing such diseases.

This is indeed hopeful news for the nearly 50 million victims of Alzheimer’s or related dementia worldwide as well as for the millions of aging people with Parkinson’s and aging-related mental decline.

Telomerase gene therapy appears to rejuvenate microglial (the immune cells of the brain) cells in Alzheimer’s Disease according to promising research study data.

Continue reading “A Novel Gene Therapy To Treat One Of The World’s Biggest Growing Chronic Disease: Dementia and Alzhiemer’s” | >

Excuses for age-related death are just that: excuses.

The knowledge that every ambition is doomed to frustration at the hands of a skeleton has never prevented the majority of human beings from behaving as though death were no more than an unfounded rumor.

The quote above is by Aldous Huxley. It sums up very well humanity’s attitude towards death, and interestingly, it can be interpreted in two opposite ways: praise for the human ability to soldier on, even in the face of inevitable demise, or a short, withering remark on how delusional we can be that, if we just ignore it really hard, maybe we don’t need to worry about death.

When I see people professing with apparently unshakable conviction the necessity of death, their not fearing it, or that—as they sometimes say in my hometown when somebody dies—” those who live have it worse”, I can’t help but think that the better interpretation of Huxley’s quote is the second one.

Continue reading “Enough with the excuses” | >

It’s in a bad taste to say that other global issues are more urgent than ageing, when pretty much all global issues—ageing included—affect the life, and the quality of life, of many people.

Suppose you’re in your mid-seventies, and you find out that your aortic valve doesn’t work very well. Undergoing a replacement operation—nowadays, a relatively simple and safe procedure—is not only going to help you with your unpleasant episodes of fatigue, chest pain, and dizziness, it may well save your life, minimizing your risk of sudden cardiac arrest.

Your doctor suggests that you undergo the procedure and sends you to a surgeon for the operation; however, when you get there, the surgeon starts yelling at you that, rather than using resources to replace your valve and extend your life, we should fund initiatives to save children in poor countries, build health clinics, train midwives, and fight for equal opportunity and for women’s rights. He then goes on rambling that, until these issues are addressed, he doesn’t want to hear about extending your natural lifespan—after all, since you’re in your mid-seventies, you’re well above the world’s average lifespan; he shoos you and your family out and slams the door on you.

The chances are good that you’d think this person was several sandwiches short of a picnic; you would report him and have him fired for malpractice. Thankfully, you’re not very likely to run into a surgeon like that, but you are likely to bump into people contending the exact same things as the mad surgeon when you replace heart surgery—a very specific form of life extension—with the general concept of life extension. Why is that?

Continue reading “Minoring in the majors” | >

Pills hailed as the first real “anti-aging” drugs inched a little closer to the market after a study found they cut the number of respiratory infections in the elderly by half.

The drugs: The pills act on an aging-related pathway called TORC1. Inhibiting this pathway “has extended life span in every species studies to date” (like mice and worms), according to Joan Mannick, who lead the study for drug giant Novartis.

Will humans live longer, too? Maybe. But that will take time to figure out. For now, what’s known is that giving people 65 and older these drugs seems to boost their immune function. Elderly people taking the drugs got about 40 percent fewer colds or bronchial infections. About 264 people got the drugs over six weeks and then were tracked for a year.

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Today we have a report from Open Longevity School: Summer Camp 2018, an initiative in Russia focused on developing a personal health and longevity strategy, Elena Milova went to investigate.

When we ask researchers when, in their opinion, the cures for aging will be ready, we often hear an optimistic answer: 20–25 years. As a well-informed optimist, I add another 10 years to this number, because wherever the therapies appear, it will take time for them to be distributed to other countries and become affordable. I will be happy if it takes less time, but what if it doesn’t? I am nearly 40, and when I add 35 years to my current age, I vividly imagine how my reflection in the mirror will show a 75-year-old lady. Honestly, I don’t want to see my body change, and it can explain why I aspire to get first-hand information about any means to slow down aging as soon as possible. Evidence-based information, of course.

Before I tell you my story of discovering how to control my aging, I must provide a disclaimer. This article does not contain any medical recommendations. The websites of the projects I will tell you about, once again, do not contain medical recommendations and cannot be independently used to make health decisions. The experience I will share, and the activities of the projects I will tell you about, are aimed at teaching you about the existing scientific knowledge about aging and interventions that have the potential to change the way we age. Whatever you decide to implement in your everyday life, please talk to your medical advisor first.

I am always looking for the means to keep myself as young as possible. Luckily for me, in Russia, there is a project focused on collecting this kind of information and making it publicly available. It is Nestarenie.ru (translation: “not aging”), an online encyclopedia created by professional sports trainer, valeologist and citizen scientist Dmitry Veremeenko. The amount of information that Dmitry has managed to process is hard to imagine; it consists of more than 70,000 scientific papers. The development of this database took him several years of work. Each article of his encyclopedia summarizes a specific drug, food or lifestyle element that can slow down or even reverse age-related changes, with a deep explanation of the underlying mechanisms. Each of his information-dense articles has lots of internal links to actual scientific papers (including the freshest meta-analyses) and finishes with a list of additional references.

Continue reading “Open Longevity School: Summer Camp 2018” | >

Is life extension at… odds with probability?

Does probability ensure that you will die, no matter what, once you are old enough? Does it throw the ultimate spanner in the works of life extension? The answer is not as clear-cut as you might think.

Recently, a study from Sapienza University in Italy has revived the idea of the so-called “mortality plateaus”—the apparent flattening of mortality rates in people aged above 100, suggesting that the maximum mortality rate of such people is 50% at age 105 [1]. However, even if this mortality rate remained constant for as long as you lived, you’d still be overwhelmingly likely to die relatively soon.

What may be even more disheartening is that, if you had a constant, larger-than-zero probability of dying, then no matter how small it was, you’d be overwhelmingly likely to die past a certain point in time, be it even billions of years into the future. As a matter of fact, over an infinite time, that probability would be exactly 100%. However, the situation is not as dire as it seems.

Continue reading “Surviving the odds” | >

Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) and the FIRC Institute of Molecular Oncology (IFOM) in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification — by confining them to a defined geometric space for an extended period of time.

“Our breakthrough findings will usher in a new generation of stem cell technologies for tissue engineering and regenerative medicine that may overcome the negative effects of geonomic manipulation,” said Prof Shivashankar.

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