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Dr. Michael Hufford, PhD — Advancing Novel Therapeutic Interventions For Unmet Medical Needs

Advancing Novel Therapeutic Interventions For Unmet Medical Needs — Dr. Michael Hufford, Ph.D., Co-Founder and CEO, LyGenesis; Interim CEO, Morphoceuticals; Scientific Advisor, Juvenescence.


Dr. Michael Hufford, Ph.D. is the Co-Founder and the Chief Executive Officer of LyGenesis (https://www.lygenesis.com/), a clinical-stage cell therapy company that transforms patient’s lymph nodes into bioreactors capable of growing functioning ectopic organs. He also serves as the Interim CEO of Morphoceuticals (https://www.morphoceuticals.com/) a company focused on modifying electric potentials in cells and tissues for a variety of applications in regenerative medicine, from improving amputation stump health and limb regeneration, to organogenesis, to creating a bioelectric atlas where numerous disease indications may be corrected.

Dr. Hufford also serves as a scientific advisor to Juvenescence (https://juvlabs.com/) a biotech holding company that develops therapies and products to modify aging and help people live longer.

An entrepreneur and drug developer, Dr. Hufford has over 20 years of experience in the development and FDA regulatory approval of small molecules (Cypress Bioscience), biologics (Amylin Pharmaceuticals), as well as drug delivery technologies (e-Nicotine Technology). He has designed and executed clinical trials and drug development programs across a wide variety of therapeutic areas, from orphan metabolic diseases to psychiatric and oncology indications. His experience in-and out-licensing pre-clinical and clinical stage assets, executing corporate partnering deals, and in investor relations, has helped him to raise public, private, and angel-back financing for his companies. His philanthropic work includes co-founding and serving as the CEO of Harm Reduction Therapeutics, Inc. (https://www.harmreductiontherapeutics.org/), a nonprofit pharmaceutical company developing low-cost over-the-counter intra-nasal naloxone in the US to help prevent opioid overdose deaths.

Dr. Hufford earned his undergraduate degree with distinction from Purdue University, and his master’s and doctoral degrees in Clinical Psychology from the University of Pittsburgh, before completing a Research and Clinical Fellowship in the Department of Psychiatry at Harvard Medical School. He is an award-winning lecturer, and the author of more than 100 scientific publications, presentations, and OpEds, with multiple issued and pending patents.

Alex Zhavoronkov: Live Long and Prosper

The maniacally focused founder of Insilico Medicine is going all in on AI to discover new medicines and extend lifespan.

But researchers are now using artificial intelligence to accelerate parts of that process by orders of magnitude. The same kind of technology that recognizes your face or autocompletes your emails can potentially add years to your life, experts say.

Forever Young: Scientists Reveal the Secret to a Strange Animal’s Eternal Youth

Sea anemones are seemingly immortal animals. They seem to be immune to aging and the negative impacts that humans experience over time. However, the exact reasons for their eternal youth are not completely understood.

The genetic fingerprint of the sea anemone Nematostella vectensis reveals that members of this incredibly ancient animal phylum employ the same gene cascades for neural cell differentiation as more complex organisms. These genes are also in charge of maintaining the balance of all cells in the organism during the anemone’s lifetime. These findings were recently published in the journal Cell Reports by a group of developmental biologists headed by Ulrich Technau of the University of Vienna.

Almost all animal organisms are made up of millions, if not billions, of cells that join together in intricate ways to create specific tissues and organs, which are made up of a range of cell types, such as a variety of neurons and gland cells. However, it is unclear how this critical balance of diverse cell types emerges, how it is regulated, and if the different cell types of different animal organisms have a common origin.

Warning: Popular Vitamin Supplement Causes Cancer Risk and Brain Metastasis

University of Missouri researchers made the discovery while using bioluminescent imaging technology to study how nicotinamide riboside supplements work inside the body.

Commercial dietary supplements like nicotinamide riboside (NR), a form of vitamin B3, were linked to benefits related to cardiovascular, metabolic, and neurological health in previous studies. However, new research from the University of Missouri (MU) has found NR could actually increase the risk of serious disease, including developing cancer.

Supplements containing nicotinamide riboside are often marketed as NAD+ boosters claimed benefits including increased energy, anti-aging/longevity/healthy aging, improved cellular energy metabolism and repair, increased vitality, and improved heart health.

Longitudinal Biomarker Optimization: A Road To Maximize Health And Longevity?

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What can blockchain do for increasing human longevity?

Longevity is not yet considered an official medical term, and aging is not officially considered a disease but a natural occurrence in every living thing.

However, some biologists, researchers and practicing doctors believe this approach should change, and they are striving to discover the mechanisms of aging in humans. In doing so, they are creating age clocks by defining biomarkers for measuring biological age, exploring the best lifestyle habits and natural supplements, and inventing new drugs that could stop us from getting older.

Longevity has been on the radar of crypto leaders for some time already, which is not a surprise given that the industry promises to improve humankind through innovation. Indeed, one prominent event in the longevity industry, the Longevity Investors Conference, is organized by Marc P. Bernegger and Tobias Reichmuth, who were previously involved with the Crypto Finance Group.

A discussion with Dr. Nir Barzaili on Age Later

Ever wonder why some 90-year olds don’t seem to slow down and seem. to retain the mental and physical capacity of someone half their age?
Do they have good genes? Or is there a way that all of us can get older without getting old?

That’s what Dr. Nir Barzilai, founder of the Institute for Aging Research at the Albert Einstein College of Medicine, set out to answer in his book, Age Later.

Dr. Nir joined us for a live Q + A discussion on Zoom.
Whether you’ve read Age Later or not, you won’t want to miss this. Because by the end of the discussion, you’ll know how to turn back the clock on aging.

Listen to the Longevity by Design podcast episode with Dr. Nir’s on genetics and lifestyle factors of centenarians here: https://hubs.li/Q01rqsV-0

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Genetics May Explain Link Between Unhealthy Teen Lifestyles and Accelerated Biological Aging

Summary: The epigenetic clocks of those who indulged in unhealthy behaviors as teens were 1.7 to 3.3 years older than individuals who reported more healthy lifestyles as teens.

Source: eLife.

Biological aging results from damage to cells and tissues in the body that accumulates over time. The results of the study could lead to new ways of identifying young people at risk of developing unhealthy habits that are associated with accelerated biological aging and suggest interventions to prevent poor health outcomes later on.

Making melanoma immortal: Pitt scientists discover key genetic step in cancer’s race to live forever

Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality.

In a paper published in Science this week, Jonathan Alder, Ph.D. and his team describe how they discovered the perfect combination of genetic alterations that tumors use to promote explosive growth and prevent their own demise, a development that could change the way oncologists understand and treat melanoma.

“We did something that was, in essence, obvious based on previous basic research and connected back to something that is happening in patients,” said Alder, assistant professor in the Division of Pulmonary, Allergy and Critical Care Medicine at Pitt’s School of Medicine.

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