Andrew Steele is a scientist, writer and presenter.
Ageing is a phenomenon we’re all familiar with and is completely taken for granted as a fact of reality, but do we have to accept.
Expect to learn why curing ageing might be easier than curing cancer and all other diseases, the unfortunate truth of fasting for longevity, why the next decade will be the most exciting for lifespan research and much more…
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One mouse is hunched over, graying, and barely moves at 7 months old. Others, at 11 months, have sleek black coats and run around. The videos and other results from a new study have inspired hope for treating children born with progeria, a rare, fatal, genetic disease that causes symptoms much like early aging. In mice with a progeria-causing mutation, a cousin of the celebrated genome editor known as CRISPR corrected the DNA mistake, preventing the heart damage typical of the disease, a research team reports today in. Treated mice lived about 500 days, more than twice as long as untreated animals.
“The outcome is incredible,” says gene-therapy researcher Guangping Gao of the University of Massachusetts, who was not involved with the study.
Although the developers of the progeria therapy aim to improve it, they are also taking steps toward testing the current version in affected children, and some other scientists endorse a rush. The mouse results are “beyond anyone’s wildest expectations,” says Fyodor Urnov, a gene-editing researcher at the University of California, Berkeley. “The new data are an imperative to treat a child with progeria … and do so in the next 3 years.”
Has some interesting parts, might interest some.
(not sure how novel)
As human beings age, the functioning of organs gradually deteriorates. While countless past studies have investigated the effects of aging on the human body, brain and on cognition, the neural mechanisms and environmental factors that can accelerate or slow down these effects are not yet fully understood.
The immune system and the nervous system are both known to play a key role in the control of organs in the body. Moreover, past findings suggest that both of these systems change significantly during aging.
Posted in food, life extension
After the tweet by David Sinclair just recently regarding a study looking at dietary restriction and the circadian clock, and the way it may impact longevity and health, I decided to have a bit of a deeper look.
Join me as I dive a little deeper, and don’t forget to subscribe to the channel to keep up with all the latest releases.
I am looking at the recent study, highlighted in a tweet by David Sinclair.
Summary: People with spinal cord injuries have the same brain activity during processing speed tasks as healthy older adults. The findings suggest the theory of accelerated cognitive aging following SCI is correct.
Source: Kessler Foundation.
A team of rehabilitation researchers has studied processing speed deficits in individuals with spinal cord injury (SCI), comparing their brain activation patterns with those of healthy age-matched controls, and older healthy individuals. They found that the SCI group and older controls had similar activation patterns, but the SCI group differed significantly from their age-matched controls.
ISRIB, a new drug that reboots protein production in cells can reverse aging declines in memory and cognition in mice, with no side effects.
Shared last year, but with the talk of future regenerative medicine I think it is important: Regenerative medicine aims to engineer tissue constructs that can recapitulate the functional and structural properties of native organs. Most novel regenerative therapies are based on the recreation of a three-dimensional environment that can provide essential guidance for cell organization, survival, and function, which leads to adequate tissue growth. The primary motivation in the use of conductive nanomaterials in tissue engineering has been to develop biomimetic scaffolds to recapitulate the electrical properties of the natural extracellular matrix, something often overlooked in numerous tissue engineering materials to date. In this review article, we focus on the use of electroconductive nanobiomaterials for different biomedical applications, particularly, very recent advancements for cardiovascular, neural, bone, and muscle tissue regeneration. Moreover, this review highlights how electroconductive nanobiomaterials can facilitate cell to cell crosstalk (i.e., for cell growth, migration, proliferation, and differentiation) in different tissues. Thoughts on what the field needs for future growth are also provided.
Bioelectricity.
Lots of good telomere info but one small problem with Mr Andrews here. He states that he agrees with the FDA that you can’t target aging as a disease since it is not measurable. Well i think this has been shown to be false as a result of epigenetic clocks.
I posted a question under the comments on the matter,(Lord Mon) we’ll see if we get a response.
Andres de Tenyi.
· 1tShponsShrorehd ·
An experimental drug reversed age-related declines in memory and mental flexibility in old mice after just a few doses, according to a study by researchers from the University of California, San Francisco (UCSF).
The drug, ISRIB, has previously been shown in other studies to restore normal cognitive function in mice after traumatic brain injury, enhance memory in healthy mice and mice with Down syndrome, as well as prevent noise-related hearing loss.
University of rochester — working at the intersection of aging, DNA repair, and cancer.
Dr. Vera Gorbunova is the Doris Johns Cherry Professor, in the Department of Biology, and Co-director, Rochester Aging Research Center, at University of Rochester.
Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals.
