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Archive for the ‘life extension’ category: Page 291

Apr 28, 2020

Reversing Ageing: New Studies Show it Can be Done

Posted by in categories: business, life extension

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Apr 28, 2020

NMN Restores Brain Function

Posted by in categories: biotech/medical, life extension, neuroscience

A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities for longevity research.

Neurovascular coupling

While the human brain is the evolutionary advantage that brought us to where we are today, operating this machine requires considerable resources. Our cerebral blood flow (CBF) accounts for 15% of cardiac output and 20% of resting total oxygen consumption, even though the brain itself comprises just 2% of body mass. CBF has to be constantly redirected to the regions of the brain that are currently active, and NVC is the mechanism in charge of this complex operation. Importantly, the CBF/cardiac output ratio decreases with age [2].

Apr 28, 2020

Molecules identified that reverse cellular aging process

Posted by in categories: biotech/medical, genetics, life extension

Central to a lot of scientific research into aging are tiny caps on the ends of our chromosomes called telomeres. These protective sequences of DNA grow a little shorter each time a cell divides, but by intervening in this process, researchers hope to one day regulate the process of aging and the ill health effects it can bring. A Harvard team is now offering an exciting pathway forward, discovering a set of small molecules capable of restoring telomere length in mice.

Telomeres can be thought of like the plastic tips on the end of our shoelaces, preventing the fraying of the DNA code of the genome and playing an important part in a healthy aging process. But each time a cell divides, they grow a little shorter. This sequence repeats over and over until the cell can no longer divide and dies.

This process is linked to aging and disease, including a rare genetic disease called dyskeratosis congenita (DC). This is caused by the premature aging of cells and is where the team focused its attention, hoping to offer alternatives to the current treatment that involves high-risk bone marrow transplants and which offers limited benefits.

Apr 27, 2020

Restoring Telomerase Activity in Telomere Biology Diseases

Posted by in categories: biotech/medical, genetics, life extension

Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres.

Telomeres and telomerase

Each chromosome that stores our genetic information has a protective cap at each end known as a telomere, a specific DNA sequence that is repeated thousands of times. This sequence has two purposes: it protects the coding regions of the chromosome and prevents it from being damaged, and it acts as a clock that controls the number of replications a cell can make; this is known as the Hayflick limit.

Apr 24, 2020

Here are the so far identified genomic variants of COVID, we are up for quite a powerful enemy!

Posted by in categories: biotech/medical, life extension

The good side is that most people who are generally healthy won’t get ill from it! smile So let’s cure aging to avoid having these pandemies upcoming in the future!

Apr 24, 2020

Refining Senolytic Drugs to Be Less Toxic and More Effective

Posted by in categories: biotech/medical, life extension

Researchers have developed a way to modify an existing cancer drug with toxic side effects into something that is less toxic to blood platelets and more effective at removing harmful and inflammatory senescent cells, one of the reasons we age, from mice.

What are senescent cells?

As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they are part; instead, they emit a range of potentially harmful chemical signals that encourage nearby healthy cells to enter the same senescent state. Their presence causes many problems: they reduce tissue repair, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases.

Apr 23, 2020

IMMORTALISTS MAGAZINE’s 4th PUBLICATION!

Posted by in categories: biotech/medical, economics, evolution, life extension

Dinorah Delphin has unveiled another magnificent issue of the Immortalists Magazine. She has clearly focused her contributing authors on the world pandemic, with impressive results.

One of the outstanding articles is from our pal, the Chairman of the USTP, Gennady Stolyarov. Gennady levels an eviscerating attack on the American health care system.

I can see that Gennady has a visceral reaction to mass death. There is passionate, broiling anger in the lines of his article. He seems to be mounting a crusade, and I’m going to confess that I’m considering arming myself for battle.

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Apr 23, 2020

How to live when nobody dies

Posted by in categories: life extension, robotics/AI

Three score and ten is so 1970s. Today, the average baby born in the UK will live long enough to see the beginning of the 22nd century. Increasingly we also hear claims of longevity breakthroughs that could propel those children – and maybe even their parents – into triple digits and beyond. Is eternal life something we want outside of science fiction? And how will society cope if it is?

“The first ten million years were the worst,” said Marvin. “The second ten million years, they were the worst, too. The third ten million years I didn’t enjoy at all. After that I went into a bit of a decline.”

So opines Marvin, Douglas Adams’ paranoid android, who follows the protagonists of ‘The Hitchhiker’s Guide to the Galaxy’ around like a bumbling, grumbling storm cloud. Functionally immortal (and cursed with a “brain the size of a planet”), Marvin is the hubristic dream of eternal life printed and stamped in circuitry. While his human shipmates stumble from one disaster to another, devoting their limited talents to avoiding death at all costs, Marvin plods glumly along, bemoaning the pointlessness of an infinite existence in which there is nothing new to learn, no challenge to his intellect and in which everyone – even his closest friend, a rat that nested for a time in his foot – dies. Except him.

Apr 23, 2020

Can Aging be Reversed? Solving the Aging Problem

Posted by in category: life extension

A transcript for this episode is available online in blog form at Transcript: Aubrey de Grey Interview on Solving the Aging Problem.

Imagine a world where we live to 130, 150 or 500 years old. Anti-aging pioneer, Dr. Aubrey de Grey, joins us to share his confidence in how technology will dramatically extend human lifespan. He joins our host, Heather Sandison, ND, to look at aging as a problem to be solved. In this episode, Dr. Aubrey de Grey offers hope to people looking for cutting-edge therapies to live longer. We discuss:

Apr 23, 2020

Study identifies potential drug treatments for telomere diseases

Posted by in categories: biotech/medical, life extension

Capping decades of research, a new study may offer a breakthrough in treating dyskeratosis congenita and other so-called telomere diseases, in which cells age prematurely. Using cells donated by patients with the disease, researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center identified several small molecules that appear to reverse this cellular aging process. Suneet Agarwal, MD, Ph.D., the study’s senior investigator, hopes at least one of these compounds will advance toward clinical trials. Findings were published April 21 in the journal Cell Stem Cell.

If so, it could be the first treatment for dyskeratosis congenita, or DC, that could reverse all of the disease’s varying effects on the body. The current treatment, , is high-risk, and only helps restore the blood system, whereas DC affects multiple organs.