‘Barcoding’ studies discovered two independent sources for blood cells in mice. If confirmed in humans, our understanding of blood cancers, bone marrow transplants, and the aging immune system will change.
The origins of our blood may not be quite what we thought. Using cellular “barcoding” in mice, groundbreaking research finds that blood cells originate not from one type of mother cell, but two, with potential implications for blood cancers, bone marrow transplant, and immunology. Fernando Camargo, PhD, of the Stem Cell Program at Boston Children’s Hospital led the study, published in the journal Nature on June 15, 2022.
“Historically, people have believed that most of our blood comes from a very small number of cells that eventually become blood stem cells, also known as hematopoietic stem cells,” says Camargo, who is also a member of the Harvard Stem Cell Institute and a professor at Harvard University. “We were surprised to find another group of progenitor cells that do not come from stem cells. They make most of the blood in fetal life until young adulthood, and then gradually start decreasing.”
Please share this event with someone that you care about.
Would you like to make a Donation to Perpetual Life? Your donations help us grow & improve our services. To donate, go to our website http://Perpetual.Life and use the PayPal button at the top right of the page. Thank you for your generous donations, we appreciate it immensely!
“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“ - Nikolai F. Fedorov.
We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.
Working to Save Lives with Age Reversal Education.
Human Longevity Inc, which was built by the pioneers of the human genome sequencing effort, and Freedom Acquisition Corporation, a publicly traded special purpose acquisition company (SPAC), have announced that they have signed a non-binding letter of intent for a proposed business combination that would result in HLI becoming a publicly listed company. Assuming everything ticks along as planned, the parties currently expect to seek approval from Freedom’s shareholders by the first quarter of 2023.
Longevity. Technology: Unicorns are the stuff of legends and headlines, and while there can be no assurance that a definitive agreement will be entered into or that the proposed transaction will be consummated, the speculation is delicious because longevity start-ups with billion-dollar valuations mean more visible, accelerating progress for the sector.
The proposed transaction values the combined company at approximately $1 billion, providing HLI with funding to pursue growth and technology innovation – watch this space!
Outer Space, Inner Space, and the Future of Networks. Synopsis: Does the History, Dynamics, and Structure of our Universe give any evidence that it is inherently “Good”? Does it appear to be statistically protective of adapted complexity and intelligence? Which aspects of the big history of our universe appear to be random? Which are predictable? What drives universal and societal accelerating change, and why have they both been so stable? What has developed progressively in our universe, as opposed to merely evolving randomly? Will humanity’s future be to venture to the stars (outer space) or will we increasingly escape our physical universe, into physical and virtual inner space (the transcension hypothesis)? In Earth’s big history, what can we say about what has survived and improved? Do we see any progressive improvement in humanity’s thoughts or actions? When is anthropogenic risk existential or developmental (growing pains)? In either case, how can we minimize such risk? What values do well-built networks have? What can we learn about the nature of our most adaptive complex networks, to improve our personal, team, organizational, societal, global, and universal futures? I’ll touch on each of these vital questions, which I’ve been researching and writing about since 1999, and discussing with a community of scholars at Evo-Devo Universe (join us!) since 2008.
For fun background reading, see John’s Goodness of the Universe post on Centauri Dreams, and “Evolutionary Development: A Universal Perspective”, 2019.
John writes about Foresight Development (personal, team, organizational, societal, global, and universal), Accelerating Change, Evolutionary Development (Evo-Devo), Complex Adaptive Systems, Big History, Astrobiology, Outer and Inner Space, Human-Machine Merger, the Future of AI, Neuroscience, Mind Uploading, Cryonics and Brain Preservation, Postbiological Life, and the Values of Well-Built Networks. He is CEO of Foresight University, founder of the Acceleration Studies Foundation, and co-founder of the Evo-Devo Universe research community, and the Brain Preservation Foundation. He is editor of Evolution, Development, and Complexity (Springer 2019), and Introduction to Foresight: Personal, Team, and Organizational Adaptiveness (Foresight U Press 2022). He is also author of The Transcension Hypothesis (2011), the proposal that universal development guides leading adaptive networks increasingly into physical and virtual inner space.
A talk for the ‘Stepping into the Future‘conference (April 2022).
At 190 years old, Jonathan the Seychelles giant tortoise recently made news for being the “oldest living land animal in the world.” Although, anecdotal evidence like this exists that some species of turtles and other ectotherms—or ‘cold-blooded’ animals—live a long time, evidence is spotty and mostly focused on animals living in zoos or a few individuals living in the wild. Now, an international team of 114 scientists, led by Penn State and Northeastern Illinois University, reports the most comprehensive study of aging and longevity to date comprising data collected in the wild from 107 populations of 77 species of reptiles and amphibians worldwide.
Among their many findings, which they report today in the journal Science, the researchers documented for the first time that turtles, crocodilians and salamanders have particularly low aging rates and extended lifespans for their sizes. The team also found that protective phenotypes, such as the hard shells of most turtle species, contribute to slower aging, and in some cases even ‘negligible aging’—or lack of biological aging.
“Anecdotal evidence exists that some reptiles and amphibians age slowly and have long lifespans, but until now no one has actually studied this on a large scale across numerous species in the wild,” said David Miller, senior author and associate professor of wildlife population ecology, Penn State. “If we can understand what allows some animals to age more slowly, we can better understand aging in humans, and we can also inform conservation strategies for reptiles and amphibians, many of which are threatened or endangered.”
At 79, he’s already outlived the CDC’s official life expectancy by two years and he has no intention of dying — or even slowing down — anytime soon. An active man, Scott jets between his homes in upstate New York and Florida, flies to exotic locations such as Panama City for business and still finds time for the odd cruise. His secret? A DIY regime of self-experimentation and untested therapies he believes will keep him going well past the next century.
Self-experimenters litter the history of medical science. Dentist Horace Wells dosed himself with nitrous oxide in 1,844 to see if it could kill pain, Nicholas Senn inflated his innards with hydrogen a few decades later to work out if it could diagnose a ruptured bowel, and more recently, Barry Marshall drank a solution containing H. pylori in 1985 to prove the bacterium caused ulcers.
These scientists risked their own health to make a medical breakthrough or prove a theory, but Scott is not a scientist. He’s an amateur enthusiast, also known as a biohacker. Biohackers engage in DIY biology, experimenting on themselves to enhance their brain and body. And many of them — like Scott — see longevity as the ultimate prize.
Researchers at the University of Houston are reporting a first-of-its-kind technology that not only repairs heart muscle cells in mice but also regenerates them following a heart attack, or myocardial infarction as its medically known.
Published in The Journal of Cardiovascular Aging 0, the groundbreaking finding has the potential to become a powerful clinical strategy for treating heart disease in humans, according to Robert Schwartz, Hugh Roy and Lillie Cranz Cullen Distinguished Professor of biology and biochemistry at the UH College of Natural Sciences and Mathematics.
The new technology developed by the team of researchers uses synthetic messenger ribonucleic acid (mRNA) to deliver mutated transcription factors — proteins that control the conversion of DNA into RNA — to mouse hearts.
As electric vehicles have become more popular across America, Texas is now putting forward a plan to expand charging infrastructure.
Vitamins are sometimes overlooked in the fight against aging compared to the vast variety of creams and serums, but research shows that vitamins are a key part of slowing the aging process. While topical serums and creams may slow the appearance of aging in areas where they are applied, they cann.
Vitamins are sometimes overlooked in the fight against aging compared to the vast variety of creams and serums, but research shows that vitamins are a key part of slowing the aging process.
While topical serums and creams may slow the appearance of aging in areas where they are applied, they cannot fight the aging happening within your body, and some anti-aging ingredients cannot be absorbed through the skin, making topical application pointless. Vitamins, meanwhile, work from the inside out, resulting in both inner and outer health. This does not mean you need to forgo topical solutions — the most powerful anti-aging regimes use both vitamins and topical creams to form a powerful, multi-pronged defense.
Vitamins and supplements help us ensure we are getting the nutrients we need, particularly if we are deficient — and according to experts, many adults do not get enough vitamin D[1] or B12,[2] leading to otherwise preventable age-related disorders and poor health.
