New York’s Gorbunova Aging Research Center team is encouraged by frailty results from SIRT6 activator trial.
SIRT6, the so-called “longevity sirtuin” has been making rather a name for itself.
SIRT6 is a protein with an important job. It is vital for both normal base excision repair and double-strand break repair of DNA damage – damage that can lead to genomic instability, which ultimately contributing to aging. These repairs decline with age but can be boosted with SIRT6 [1].
But SIRT6 has another string to its longevity bow; back in 2019, Vera Gorbunova, professor of biology at the University of Rochester, and her team, demonstrated an overexpression of SIRT6 protein leads to extended lifespan. The researchers also showed that the opposite is also true – a deficiency in SIRT6 can cause premature aging [2].
Innovative Solutions For Unmet Needs Of Older Adults & Their Caregivers — Keith Camhi, Managing Director, Techstars Future of Longevity Accelerator — A Partnership With Melinda Gates Pivotal Ventures.
Keith Camhi is Managing Director, Techstars Future of Longevity Accelerator (https://www.techstars.com/accelerators/longevity), a program, run in partnership with Pivotal Ventures (https://www.pivotalventures.org/), an investment and incubation company created by Melinda French Gates, focusing on innovative solutions to address the unmet needs of older adults and their caregivers. The longevity accelerator core program themes include: Caregiver Support, Care Coordination, Aging in Place, Financial Wellness and Resilience, Preventive Health (both Physical and Cognitive), and Social Engagement.
Keith was previously the SVP of Accelerators for Techstars globally and was inspired to move to the MD role for the longevity program based on having built a venture-backed startup serving older adults himself, having experienced the gaps in America’s care giving infrastructure firsthand, and wanting to support entrepreneurs who are building solutions to address this substantial market opportunity.
Techstars is a global investment business that provides access to capital, one-on-one mentorship, a worldwide network and customized programming for early-stage entrepreneurs. It was founded in 2006 in Boulder, Colorado. As of May 2022, the company had accepted over 2,900 companies into its accelerator programs with a combined market capitalization of US$71 billion.
Prior to Techstars, Keith founded and led the rapid growth of two tech companies in the health and fitness industry – one that reached #20 on the Deloitte Fast 500, and another that made Entrepreneur’s Franchise 500 three times. He has raised over $50 million in venture funding, holds several patents for sensor and machine vision technology, has been an angel investor and LP in several venture funds, and enjoys mentoring promising startups.
How can we live longer and be healthier? These startups are trying to extend our lives. ✱ Download the Dizraptor app to invest in technologies of the future https://dizraptor.onelink.me/1kIK/samumed.
What’s inside: 00:00 How to make money. 01:42 How has human lifespan increased over history. 03:06 Top 1 04:28 Top 2 05:21 Top 3 05:43 Top 4 06:12 Top 5 06:48 What will the longevity economy change?
Within minutes of the final heartbeat, a cascade of biochemical events triggered by a lack of blood flow, oxygen, and nutrients begins to destroy a body’s cells and organs. But a team of Yale scientists has found that massive and permanent cellular failure doesn’t have to happen so quickly.
The researchers stressed that additional studies are necessary to understand the apparently restored motor functions in the animals, and that rigorous ethical review from other scientists and bioethicists is required.
The experimental protocols for the latest study were approved by Yale’s Institutional Animal Care and Use Committee and guided by an external advisory and ethics committee.
The OrganEx technology could eventually have several potential applications, the authors said. For instance, it could extend the life of organs in human patients and expand the availability of donor organs for transplant. It might also be able to help treat organs or tissue damaged by ischemia during heart attacks or strokes.
A study into bone loss in astronauts returning from long spaceflights has shown that some may have incomplete bone recovery even after one year back on Earth, with sustained losses equivalent to 10 years of normal age-related bone loss on Earth.
An organism uses programmed cell death as a critical tool to maintain its health. Various stress responses are triggered when a cell does not operate as it should. These responses aim to bring back the original cell function.
One example is the process known as autophagy, in which a cell partly digests itself in order to acquire energy that it can utilize for its own repair. Should these efforts fail, the cell dies. This enables the body to combat conditions including infections, diabetes, cancer, and neurodegeneration.
Circa 2020 Reversing the biological clock to essentially reverse aging.
Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice, suggesting that mammalian tissues retain a record of youthfu…
Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics.
Scientists around the world are scurrying to reverse the hands of time. Here’s a look at one lab’s search for the fountain of youth, where old mice have grown young again.
