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Open Longevity
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Category: life extension – Page 187
One of the most upsetting aspects of age-related memory decline is not being able to remember the face that accompanies the name of a person you just talked with hours earlier. While researchers don’t understand why this dysfunction occurs, a new study conducted at University of Maryland School of Medicine (UMSOM) has provided some important new clues. The study was published on September 8 in Aging Cell.
Using aging mice, researchers have identified a new mechanism in neurons that causes memories associated with these social interactions to decline with age. In addition, they were able to reverse this memory loss in the lab.
The researchers report that their findings identified a specific target in the brain that may one day be used to develop therapies that could prevent or reverse memory loss due to typical aging. Aging memory problems are distinct from those caused by diseases like Alzheimer’s or dementia. At this time, there are no medications that can prevent or reverse cognitive decline due to typical aging.
00:00 Intro.
02:44 Kernel Flow brain interface.
08:03 Seeing my brain activity.
12:42 Reversing aging-Project Blueprint.
18:18 Overcoming depression.
26:42 Starting Kernel.
34:40 Why non-invasive?
36:43 Comparison to Tesla/ Neuralink.
43:52 Elon considered joining Kernel?
44:52 Kernel hiring.
46:17 Participate in the studies.
Participate & experience Kernel Flow: https://www.kernel.com/participate.
Information: Kernel Flow: https://www.kernel.com/flow.
Kernel Careers: https://jobs.lever.co/kernel-2
Neura Pod Episode about Kernel & Bryan Johnson: https://youtu.be/c0VFiEhDg6I
Bryan Johnson LinkedIn: https://www.linkedin.com/in/bryanrjohnson/
Bryan Johnson Personal Page: https://www.bryanjohnson.co/
Blueprint Website: https://blueprint.bryanjohnson.co/
After selling his company, Braintree/Venmo, for $800 million and battling chronic depression for 10 years, Bryan Johnson is now on a mission to help us measure and gather more data about the organ that makes us oh-so human: our brain.
In this episode, Ryan Tanaka and Omar Olivares share an exclusive, behind the scenes look of Kernel’s headquarters near Los Angeles, California. Ryan interviews Bryan Johnson, tries on Kernel’s wearable brain-interface, ‘Flow,’ and learns about the engineering and technology developments needed to make it all happen. CTO, Ryan Field and Director of Applied Neuroscience, Katherine Perdue also share insights about Kernel’s wearable Flow headset.
A talk for the international audience of Technology Universe (https://technologyuniverse.net/) by futurist Brian Wang.
Other videos by Brian Wang on Space, Replicating factories, future teslabots and antiaging.
Fully and Rapidly Replicable Factories — the Most Important Product Ever.
Brian Wang interviews Aubrey de Grey.
Research into how the blood protein vitronectin changes when under pressure – such as when it passes through the blood vessels at the back of the eye – could unlock the mechanism of macular degeneration.
Research led by Sanford Burnham Prebys professor Francesca Marassi, Ph.D., is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.
The study, published recently in the Biophysical Journal, describes the flexible structure of a key blood protein involved in macular degeneration and other age-related diseases, such as Alzheimer’s and atherosclerosis.
“Proteins in the blood are under constant and changing pressure because of the different ways blood flows throughout the body,” says Marassi. “For example, blood flows more slowly through small blood vessels in the eyes compared to larger arteries around the heart. Blood proteins need to be able to respond to these changes, and this study gives us fundamental truths about how they adapt to their environment, which is critical to targeting those proteins for future treatments.”
Circa 2021 face_with_colon_three
Welwitschia mirabilis is a unique plant that only has two leaves, but it can survive in hostile conditions of the African desert. Here, the authors report its chromosome-level genome assembly and discuss how gene function and regulation have given rise to its unique morphology and environmental adaptions.
Cyborgs transhumanist and futurists.
Museum of Science | Boston, MA
March 28th, 2018
We’ve all heard of Terminator, Blade Runner, and other science fiction about cyborgs. But how far is reality from fiction? Can scientists transform humans into machine-like creatures, stronger, smarter and, who knows, even immortal?
A year back and bodily function improves, and it’s a shot rather than transfusion as needed from other plasma treatments.
Researchers have found that intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people [1].
Circulating proteins have a significant impact on our health, and blood plasma transfusion is increasingly used against inflammatory conditions as well as some autoimmune and genetic diseases [2]. Basically, plasma transfusion enables physicians to alter the concentration of interesting molecules in the blood.
In recent years, Michael and Irina Conboy, along with other researchers, have experimented with blood/plasma exchange in the context of longevity [3]. Their continuing research has shown that heterochronic parabiosis (blood exchange between old and young animals), as well as plasma transfusion and even dilution of old plasma [4], alleviate various aspects of aging and decrease biological age as measured by methylation clocks.
Did they unlock one of the vital keys to stop aging?
According to a recent National Eye Institute (NEI) study in mice, loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may promote age-related changes in the retina.
Age-related retinal diseases, such as age-related macular degeneration (AMD), can cause blindness since the retina is the light-sensitive tissue at the back of the eye. The new information could help develop medicines to stop AMD and other aging conditions of the retina. The research was published in the International Journal of Molecular Sciences. NEI is part of the National Institutes of Health.
“People have called PEDF the ‘youth’ protein because it is abundant in young retinas, but it declines during aging,” said Patricia Becerra, Ph.D., chief of NEI’s Section of Protein Structure and Function and senior author of the study. “This study showed for the first time that just removing PEDF leads to a host of gene changes that mimic aging in the retina.”