Lifeboat Foundation

Red blood cells are the most abundant cell type in blood, carrying oxygen throughout the human body. In blood circulation, they repetitively encounter various levels of oxygen tension. Hypoxia, a low oxygen tension condition, is a very common micro-environmental factor in physiological processes of blood circulation and various pathological processes such as cancer, chronic inflammation, heart attacks and stroke. In addition, an interplay between poor cellular deformability and impaired oxygen delivery is found in various pathological processes such as sickle cell disease. Sickle red blood cells simultaneously undergo drastic mechanical deformation during the sickling and unsickling process.

The interactions between hypoxia and cell biomechanics and the underlying biochemical mechanisms of the accelerated damage in diseased red blood cells are well understood, however, the exact biomechanical consequences of hypoxia contributing to red blood cell degradation (aging) remains elusive.

Researchers from Florida Atlantic University’s College of Engineering and Computer Science, in collaboration with the Massachusetts Institute of Technology (MIT), sought to identify the role of hypoxia on red blood cell aging via the biomechanical pathways. In particular, they examined hypoxia-induced impairment of red blood cell deformability at the single cell level, compared the differences between non-cyclic hypoxia and cyclic hypoxia, and documented any cumulative effect vs. hypoxia cycles, such as aspects that have not been studied quantitatively. Red blood cell deformability is an important biomarker of its functionality.

Yes he starts with his personal controversy, emerging challenges, TAME, longevity is moving along well but has a long way to go.

Dr. Aubrey de Grey discusses the changing priorities at the forefront of the field of longevity rejuvenation research at Lifespan.io’s 2021 EARD conference. “The crusade is accelerating”, says Dr. De Grey, “but there’s so much still to do.”
De Grey is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies.

Continue reading “Dr. Aubrey de Grey — Changing Priorities in Rejuvenation Technologies — Lifespan.io” »

This is the video of Harold Katcher’s presentation to the London Futurists. It was a great discussion, be sure to check it out.

#haroldkatcher #antiaging #rejuvenation #futurism

Continue reading “A paradigm shift in aging research?” »

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Levine’s Biological age calculator is embedded as an Excel file in this link:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

A newly discovered manipulation mechanism used by parasitic bacteria to slow down plant aging, may offer new ways to protect disease-threatened food crops.

Parasites manipulate the organisms they live off to suit their needs, sometimes in drastic ways. When under the spell of a parasite, some plants undergo such extensive changes that they are described as “zombies”. They stop reproducing and serve only as a habitat and host for the parasitic pathogens.

Until now, there’s been little understanding of how this happens on a molecular and mechanistic level.

What do you do when you’re so rich you could live to be a hundred and still not spend a noticeable fraction of your fortune? Buy yourself some more time. Literally.

The Amazon founder Jeff Bezos, 57 was reported last week to be among the backers of a new “rejuvenation company”, Altos Labs, a Silicon Valley start-up that has set its sights on understanding why we age and how we might prevent it — and ultimately work out how we might live for ever.

Bezos is not the only billionaire looking towards his end days. The men behind Google and Facebook are also dabbling in the dark art of manipulating mortality. But are they altruistically investing for the good of humanity — or is this.

https://www.youtube.com/watch?v=GgHYCU5qB_4

Hey it’s Han from WrySci HX talking about a really interesting concept — the world’s first biological gaming console that uses nanopore technology to detect molecules, and turn these readouts into games! It’s called the Demonpore 64! More below ↓↓↓

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Continue reading “Can Video Games Defeat Aging? World’s First Scientific Gaming Console: Demonpore 64” »

Researchers at Université de Montréal and McGill University have discovered a new multi-enzyme complex that reprograms metabolism and overcomes “cellular senescence,” when aging cells stop dividing.

In their study published today in Molecular Cell, the researchers show that an enzyme complex named HTC (hydride transfer complex) can inhibit cells from aging.

“HTC protects cells from hypoxia, a lack of oxygen that normally leads to their death,” said senior author Gerardo Ferbeyre, an UdeM biochemistry professor and principal scientist at the CRCHUM, the university’s affiliated teaching hospital research center.

Reducing naturally occurring errors in protein synthesis (production) improves both health and lifespan, finds a new study in simple model organisms led by researchers at UCL and MRC London Institute of Medical Sciences.

The novel findings, published in Cell Metabolism, are the first to demonstrate a direct link between fewer protein mistakes and longevity.

Explaining the study, lead author Dr. Ivana Bjedov (UCL Cancer Institute), said: We commonly hear about DNA mutations, which can cause cancer, and are considered one of the underlying causes of ageing.