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Category: life extension – Page 189

Patreon support: https://www.patreon.com/braininspired.

Free Video Series: Open Questions in AI and Neuroscience:

BI Workshop- Open Questions Ever

Show notes: https://braininspired.co/podcast/103/

Randal, Ken, and I discuss a host of topics around the future goal of uploading our minds into non-brain systems, to continue our mental lives and expand our range of experiences. The basic requirement for such a subtrate-independent mind is to implement whole brain emulation. We discuss two basic approaches to whole brain emulation. The “scan and copy” approach proposes we somehow scan the entire structure of our brains (at whatever scale is necessary) and store that scan until some future date when we have figured out how to us that information to build a substrate that can house your mind. The “gradual replacement” approach proposes we slowly replace parts of the brain with functioning alternative machines, eventually replacing the entire brain with non-biological material and yet retaining a functioning mind.

Continue reading “BI 103 Randal Koene and Ken Hayworth: The Road to Mind Uploading” | >

Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Michael’s Twitter: https://twitter.com/drmichaellevin.
Michael’s Website: https://drmichaellevin.org.
Michael’s Papers:
Biological Robots: https://arxiv.org/abs/2207.00880
Synthetic Organisms: https://tandfonline.com/doi/full/10.1080/19420889.2021.2005863
Limb Regeneration: https://science.org/doi/10.1126/sciadv.abj2164

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast.
Apple Podcasts: https://apple.co/2lwqZIr.
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4
Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41

OUTLINE:

Continue reading “Michael Levin: Biology, Life, Aliens, Evolution, Embryogenesis & Xenobots | Lex Fridman Podcast #325” | >

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
Program & apply to join: https://foresight.org/biotech-health-extension-program/

Jennifer Garrison, Buck Institute.
Reframing Health and Aging through the Lens of Reproduct.

Jennifer Garrison is an assistant professor at the Buck Institute for Research on Aging and also holds appointments in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco (UCSF) and the Davis School of Gerontology at the University of Southern California. During her doctoral studies at UCSF with Jack Taunton, she discovered the molecular target of a natural product and elucidated a novel mechanism by which small molecules can regulate protein biogenesis.

Join us:

Continue reading “Jennifer Garrison, Buck Institute | Reframing Health and Aging through the Lens of Reproduct” | >

Brain-age (BA) estimates based on deep learning are increasingly used as neuroimaging biomarker for brain health; however, the underlying neural features have remained unclear. We combined ensembles of convolutional neural networks with Layer-wise Relevance Propagation (LRP) to detect which brain features contribute to BA. Trained on magnetic resonance imaging (MRI) data of a population-based study (n = 2,637, 18–82 years), our models estimated age accurately based on single and multiple modalities, regionally restricted and whole-brain images (mean absolute errors 3.37–3.86 years). We find that BA estimates capture ageing at both small and large-scale changes, revealing gross enlargements of ventricles and subarachnoid spaces, as well as white matter lesions, and atrophies that appear throughout the brain. Divergence from expected ageing reflected cardiovascular risk factors and accelerated ageing was more pronounced in the frontal lobe. Applying LRP, our study demonstrates how superior deep learning models detect brain-ageing in healthy and at-risk individuals throughout adulthood.

Read more | >

A team of researchers affiliated with several institutions in Switzerland and the U.S. reports evidence that the genetics of longevity are influenced by both gender and age. In their paper published in the journal Science, the group describes their study of aging in mice and humans. João Pedro de Magalhães, with the University of Birmingham, has published a Perspective piece in the same journal issue outlining the technical challenges to understanding how aging works and the work done by the team on this new effort.

Scientists have been studying the for many years but still do not have a good explanation for why organisms age and why some live longer than others. In this new effort, the researchers wondered if something in the genome plays a role in how long a species lives on average.

Noting that another team had created a very large dataset of information regarding aging in nearly 3,000 mice, the researchers found that it also contained . After obtaining access to the database, they analyzed that genetic information—more specifically, they conducted quantitative trait locus mapping. They found multiple loci that they could associate with longevity, some that were specific to one or the other gender. They also found that mice who weighed more during their early years or who had small litter sizes tended to die younger. They suggest the same that were associated with aging may have also played a role in the other two traits. The researchers also found that the aging-related genes they isolated appeared to remain dormant until the latter stages of a given individual’s life.

Read more | >

With more of us living into old age than at any other time, dementia is increasing steadily worldwide, with major individual, family, societal and economic consequences.

Treatment remains largely ineffective and aspects of the underlying pathophysiology are still unclear. But there is good evidence that —and their manifestation as dementia—are not an inevitable consequence of aging.

Many causes of dementia, including viral infections, are preventable.

Read more | >

Including decaffeinated and instant ones.

A new study conducted by Australian scientists suggests that consuming two to three cups of decaffeinated, ground, and instant coffee can lower the risk of developing cardiovascular disease and dying early.

“In this large, observational study, ground, instant, and decaffeinated coffee were associated with equivalent reductions in the incidence of cardiovascular disease and death from cardiovascular disease or any cause,” says study author Professor Peter Kistler of the Baker Heart and Diabetes Research Institute in a media release.

“The results suggest that mild to moderate intake of ground, instant, and decaffeinated coffee should be considered part of a healthy lifestyle.”

Full Story:

Continue reading “Drinking 2 to 3 cups of coffee per day could have a surprising effect on longevity” | >

Personalized Bio-Engineered Human Hearts For All — Dr. Doris A. Taylor, Ph.D., CEO, Organamet Bio Inc.

Dr. Doris A. Taylor, Ph.D. is Chief Executive Officer of Organamet Bio Inc. (https://organametbio.com/) an early phase start-up committed to saving lives and reducing the cost of healthcare for those with heart disease. Organamet has a goal is to make personalized bio-engineered human hearts, available to all who need them, within 5 years, increasing availability and access to hearts, decreasing or eliminating need for immunosuppression, reducing total lifetime transplant costs, and improving quality of life.

Dr. Taylor was previously the Director, Regenerative Medicine Research and Director, Center for Cell and Organ Biotechnology, at the Texas Heart Institute in Houston, Texas, where she worked on the integration of regenerative medicine and tissue engineering.

Continue reading “Dr. Doris A. Taylor, Ph.D. — CEO, Organamet Bio Inc. — Personalized Bio-Engineered Human Hearts” | >