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Archive for the ‘genetics’ category: Page 94

Sep 5, 2023

Curing aging should be a moral imperative for all of humanity

Posted by in categories: biotech/medical, cryonics, ethics, genetics, life extension, robotics/AI

The Death of Death is an international bestseller by José Cordeiro and David Wood that claims that “death will be optional by 2045” – or even earlier, if more public and private funds are invested in rejuvenation technologies.

Longevity. Technology: Already available in more than 10 languages, the book provides insight into recent exponential advances in AI, tissue regeneration, stem cell treatment, organ printing, cryopreservation and genetic therapies that, say the authors, offer a realistic chance to solve the problem of the aging of the human body for the first time in human history. In fact, the book’s subtitle is The Scientific Possibility of Physical Immortality and its Moral Defense.

Given that until relatively recently, just mentioning the concept of ‘biological immortality’ was enough to raise eyebrows and with most of the opinion that it should be filed away under ‘science fiction’ or ‘charlatanism’. However, longevity science is advancing at an incredible pace and today there are people who no longer wonder if immortality is possible, but when it will be a reality. We sat down with José Luis Corderio PhD to find out more.

Sep 5, 2023

Few People with Cancer Undergo Germline Testing

Posted by in categories: biotech/medical, genetics

Like biomarker tests, germline testing can help doctors determine the best treatments for patients, but such testing may also help identify people whose family members should be offered testing for potential cancer-causing gene changes.

Guidelines recommend that germline testing be offered to all people with male breast cancer, ovarian cancer, pancreatic cancer, and metastatic prostate cancer. For other cancers with lower likelihood of harmful inherited mutations, recommendations for germline testing vary.

But new findings from a study that is examining the extent of testing for germline mutations among people diagnosed with cancer in California and Georgia between 2013 and 2019 found that germline testing rates are still low. Among the more than 1.3 million people in the study, only about 93,000, or 6.8%, underwent germline genetic testing through March 31, 2021, according to findings published July 3 in JAMA.

Sep 4, 2023

First-in-class targeted microRNA therapy slows cancer tumor growth

Posted by in categories: biotech/medical, genetics

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division. As reported in Oncogene, tumors treated with the new therapy did not increase in size over the course of a 21-day study, while untreated tumors tripled in size over the same time period. The paper is tiled “A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy.”

Cancer can begin almost anywhere in the human body. It is characterized by cells that divide uncontrollably and that may be able to ignore signals to die or stop dividing, and even evade the . The therapy, tested in mouse models, combines a delivery system that targets cancer cells with a specially modified version of microRNA-34a, a molecule that acts “like the brakes on a car,” slowing or stopping cell division, said Andrea Kasinski, lead author and the William and Patty Miller Associate Professor of biological sciences at Purdue University.

In addition to slowing or reversing , the targeted microRNA-34a strongly suppressed the activity of at least three genes—MET, CD44 and AXL—known to drive cancer and resistance to other cancer therapies, for at least 120 hours. The results indicate that the patent-pending therapy, the newest iteration in more than 15 years of work targeting microRNA to destroy cancer, could be effective on its own and in combination with existing drugs when used against cancers that have built .

Sep 4, 2023

Artificial Intelligence: Transforming Healthcare, Cybersecurity, and Communications

Posted by in categories: augmented reality, bioengineering, cybercrime/malcode, economics, genetics, information science, robotics/AI, sustainability

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More remarkably, the advent of artificial intelligence (AI) and machine learning-based computers in the next century may alter how we relate to ourselves.

Continue reading “Artificial Intelligence: Transforming Healthcare, Cybersecurity, and Communications” »

Sep 4, 2023

Harnessing deep learning for population genetic inference

Posted by in categories: genetics, robotics/AI

Applying deep learning to large-scale genomic data of species or populations is providing new opportunities to understand the evolutionary forces that drive genetic diversity. This Review introduces common deep learning architectures and provides comprehensive guidelines to implement deep learning models for population genetic inference. The authors also discuss current opportunities and challenges for deep learning in population genetics.

Sep 4, 2023

Two-pronged immunotherapy approach could treat most blood cancers

Posted by in categories: biotech/medical, genetics

Strategy using genetically engineered T cells would attack cancer while sparing healthy blood stem cells.

Sep 3, 2023

Human ancestors nearly went extinct 900,000 years ago

Posted by in category: genetics

A new technique analysing modern genetic data suggests that pre-humans survived in a group of only 1,280 individuals.

Sep 3, 2023

Did Tryptophan And/Or Serine Mess Up Blood Biomarkers? (Blood Test #5 in 2023 Analysis)

Posted by in categories: biotech/medical, genetics, health

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Sep 3, 2023

Transferring Longevity DNA Across Species: Gene from Naked Mole Rat Extends Mouse Lifespan

Posted by in categories: biotech/medical, genetics, life extension

Naked mole rats are rodents that are about the size of a mouse with a key difference, aside from having no fur — they’re extremely long-lived — reaching ages of around 40 years old. For comparison, lab mice live an average of about three and a half years. To explain their extensive lifespans, researchers have sought to pinpoint how naked mole rats evade the onset of age-related diseases like cancer. In doing so, they’ve identified a form of gelatinous substance called hyaluronan, which has anti-inflammatory and anticancer properties. Now, the question of whether the benefits of the naked mole rat’s abundant levels of this form of hyaluronan — called high molecular mass hyaluronic acid (HMM-HA) — can be exported to other species has recently drawn attention.

Published in Nature, Gorbunova and colleagues from the University of Rochester show that genetically modifying mice to harbor an enzyme that produces HMM-HA extends their lifespan. The researchers go on to show that increasing HMM-HA reduces the prevalence of cancer. Additionally, the nmrHAS2 gene improves the healthspan of mice by countering physiological dysfunction, as measured with a frailty score. These findings provide the first evidence that genes from long-lived species can be exported to other species, perhaps conferring benefits to humans one day.

Sep 2, 2023

Scientists Uncover Secrets of Plant Regeneration

Posted by in categories: biotech/medical, genetics

Plants possess the unique ability to completely regenerate from a somatic cell, i.e., an ordinary cell that does not typically participate in reproduction. This process involves the de novo (or new) formation of a shoot apical meristem (SAM) that gives rise to lateral organs, which are key for the plant’s reconstruction.

On a cellular scale, the formation of SAM is meticulously controlled by either positive or negative regulators (genes/protein molecules) that may induce or restrict shoot regeneration, respectively. But which molecules are involved? Are there other regulatory layers that are yet to be uncovered?

To seek answers to the above questions, a research group led by Nara Institute of Science and Technology (NAIST), Japan studied the process in Arabidopsis, a plant commonly used in genetic research.

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