Lifeboat Foundation

Now maybe we can snack happily! I think this applies to regular food too? I can eat all the Chinese and Mexican and Italian food I want? Plus for people with genetic risks can’t this not help? I hope so.

Mice fed a high-sugar, high-fat diet for most of their lives managed to escape weight gain and protect their livers when they were treated with an experimental new drug.

The small-molecule drug was developed by a team led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio). K nown by its chemical acronym CPACC, it works by limiting the entry of magnesium into the mitochondria, the parts of the cell in charge of generating energy and burning calories.

Continue reading “Scientists Develop Drug That Prevents Weight Gain in Junk-Food-Eating Mice” »

Likewise, this dataset had 4,510 cases, 212,242 controls, with 16,380,464 SNPs for psoriasis, and 2,802 cases, 212,242 controls, with 16,380,459 SNPs for psoriasis vulgaris.

The team analyzed the aggregated statistical data using an MR approach to explore the potential causal relationship between the gut microbiome and psoriasis. SNPs with a threshold P-value of 1 × 10⁻⁵ worked as genetic instrumental variables in these MR analyses.

While searching for answers about their son’s condition, Karlie and Evan Anderson made a startling discovery: despite living for 30 years without any symptoms, Evan tested positive for Marfan syndrome, a genetic disorder that nearly cost him his life. NBC’s Kaylee Hartung reports for TODAY.

A new study from the University of Minnesota is the first to demonstrate the ability for gene therapy to repair neural connections for those with the rare genetic brain disorder known as Hurler syndrome. The findings suggest the use of gene therapies—an entirely new standard for treatment—for those with brain disorders like Hurler syndrome, which have a devastating impact on those affected.

The largest ever study of the genetics of the brain – encompassing some 36,000 brain scans – has identified more than 4,000 genetic variants linked to brain structure. The results of the study, led by researchers at the University of Cambridge, are published in Nature Genetics today.

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Continue reading “Uremic Metabolites: Kidney Function Biomarkers” »

The research, published in Proceedings of the National Academy of Sciences, used a genetic approach to fix deafness in mice with a defective Spns2 gene, restoring their hearing abilities in low and middle frequency ranges. Researchers say this proof-of-concept study suggests that hearing impairment resulting from reduced gene activity may be reversible.

Over half of adults in their 70s experience significant hearing loss. Impaired hearing is associated with an increased likelihood of experiencing depression and cognitive decline, as well as being a major predictor of dementia. While hearing aids and cochlear implants may be useful, they do not restore normal hearing function, and neither do they halt disease progression in the ear. There is a significant unmet need for medical approaches that slow down or reverse hearing loss.

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has successfully reversed hearing loss in mice.

Continue reading “Researchers reverse hearing loss in mice” »

Group A streptococci are one of the most common pathogens that humans are exposed to, and they can cause infections with a wide range of severities, from mild rashes and sore throats to flesh-eating and systemic infections that can be fatal. The number of these infections is also on the rise, although the reasons are unclear. Now researchers have learned more about why these pathogens can be mild in some people, and hit others hard. The findings have been reported in Nature Communications.

Scientists suspected that some interaction between a person’s genetics and the bacterial pathogen could be leading to such varied outcomes, said study co-author Fredric Carlsson, a researcher at Lund University.

A genetically modified pig kidney transplanted into a brain-dead man on life support has exhibited regular functioning for over a month, showing no signs of rejection or infection.

A new milestone in animal-to-human organ transplants in the United States has been achieved.

A gene-edited pig kidney implanted into a brain-dead man on life support has been functioning normally for over a month with no signs of rejection or infection.