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Archive for the ‘genetics’ category: Page 9

Sep 13, 2024

Creating Life’s Operating System

Posted by in categories: biotech/medical, computing, genetics

Have we created an operating system for life? How close are we to cloning humans, and what would that even look like?

You’re in for a fascinating episode as the line between science and science fiction gets blurred. My guest is microbiologist and geneticist Andrew Hessel, the CEO and Founder of The Genome Project-Write, and author of \.

Sep 12, 2024

Efficient genetic code expansion without host genome modifications

Posted by in categories: biotech/medical, genetics

Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage.

Sep 11, 2024

Genetic testing to be banned from life insurance, income protection, disability cover

Posted by in categories: biotech/medical, genetics, government

Life insurers and those offering income protection and permanent disability insurance will be banned from using genetic testing to refuse cover, or hike up charges, for a range of insurance products.

The federal government announced on Tuesday it would ban the practice that saw consumers discriminated against if they disclosed the results of genetic tests that predict their likelihood of an inherited disease.

It comes after consultation to address genetic discrimination in life insurance earlier this year. More than 1,000 submissions were received with 97 per cent supporting a total ban.

Sep 10, 2024

A comprehensive map of the aging blood methylome in humans

Posted by in categories: biotech/medical, genetics, life extension

During aging, the human methylome undergoes both differential and variable shifts, accompanied by increased entropy. The distinction between variably methylated positions (VMPs) and differentially methylated positions (DMPs), their contribution to epigenetic age, and the role of cell type heterogeneity remain unclear.

We conduct a comprehensive analysis of 32,000 human blood methylomes from 56 datasets (age range = 6–101 years). We find a significant proportion of the blood methylome that is differentially methylated with age (48% DMPs; FDR 0.005) and variably methylated with age (37% VMPs; FDR 0.005), with considerable overlap between the two groups (59% of DMPs are VMPs). Bivalent and Polycomb regions become increasingly methylated and divergent between individuals, while quiescent regions lose methylation more uniformly. Both chronological and biological clocks, but not pace-of-aging clocks, show a strong enrichment for CpGs undergoing both mean and variance changes during aging. The accumulation of DMPs shifting towards a methylation fraction of 50% drives the increase in entropy, smoothening the epigenetic landscape. However, approximately a quarter of DMPs exhibit anti-entropic effects, opposing this direction of change.

Sep 10, 2024

The role of metabolites in pluripotent stem cell modification

Posted by in categories: biotech/medical, genetics

Dissecting the molecular mechanism controlling the epigenetic profile of pluripotent stem cells.„, European Commission.

Sep 10, 2024

Genetic Testing Company Must Issue Refunds After Security Breach Disaster

Posted by in categories: genetics, security

1Health.io left its customers genetic information unsecured in unencrypted and publicly accessible AWS servers.

Sep 9, 2024

Genetic associations with human longevity are enriched for oncogenic genes

Posted by in categories: biotech/medical, genetics, life extension

Human lifespan is shaped by both genetic and environmental exposures and their interaction. To enable precision health, it is essential to understand how genetic variants contribute to earlier death or prolonged survival. In this study, we tested the association of common genetic variants and the burden of rare non-synonymous variants in a survival analysis, using age-at-death (N = 35,551, median [min, max] = 72.4 [40.9, 85.2]), and last-known-age (N = 358,282, median [min, max] = 71.9 [52.6, 88.7]), in European ancestry participants of the UK Biobank. The associations we identified seemed predominantly driven by cancer, likely due to the age range of the cohort. Common variant analysis highlighted three longevity-associated loci: APOE, ZSCAN23, and MUC5B. We identified six genes whose burden of loss-of-function variants is significantly associated with reduced lifespan: TET2, ATM, BRCA2, CKMT1B, BRCA1 and ASXL1. Additionally, in eight genes, the burden of pathogenic missense variants was associated with reduced lifespan: DNMT3A, SF3B1, CHL1, TET2, PTEN, SOX21, TP53 and SRSF2. Most of these genes have previously been linked to oncogenic-related pathways and some are linked to and are known to harbor somatic variants that predispose to clonal hematopoiesis. A direction-agnostic (SKAT-O) approach additionally identified significant associations with C1orf52, TERT, IDH2, and RLIM, highlighting a link between telomerase function and longevity as well as identifying additional oncogenic genes.

Our results emphasize the importance of understanding genetic factors driving the most prevalent causes of mortality at a population level, highlighting the potential of early genetic testing to identify germline and somatic variants increasing one’s susceptibility to cancer and/or early death.

The authors have declared no competing interest.

Sep 8, 2024

New large scale gene editing technique

Posted by in categories: bioengineering, biotech/medical, genetics

A novel method utilising genes in our body to perform long-sequence DNA recombination and editing, called the RNA bridge, has been discovered and reported by genetic engineers. ThePrint #̦PureScience, Sandhya Ramesh explains the findings and implications.

Sources and further reading:

Continue reading “New large scale gene editing technique” »

Sep 8, 2024

6y Younger Horvath Epigenetic Age: My Best Data Yet (16-Test Analysis)

Posted by in category: genetics

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links/Affiliates (Ways To Test Yourself, While Also Helping To Support The Channe):…

Sep 7, 2024

Gene therapy restores sight with up to 10,000-fold vision improvement

Posted by in categories: biotech/medical, genetics

This gene therapy treats LCA1, causing early childhood vision loss, affecting under 100,000 people:


“One patient reported for the first time being able to navigate at midnight outdoors only with the light of a bonfire,” said Cideciyan, who is also co-director of the Center for Hereditary Retinal Degenerations.

Continue reading “Gene therapy restores sight with up to 10,000-fold vision improvement” »

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