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Category: genetics – Page 9

Protective genetic variants against Alzheimer’s disease

Genetic studies can offer powerful insights for the development of disease-modifying therapies for Alzheimer’s disease. Protective genetic variants that delay the onset of cognitive impairment have been found in people with sporadic Alzheimer’s disease and in carriers of mutations that usually cause autosomal-dominant Alzheimer’s disease in mid-life. The study of families who carry autosomal dominant mutations provides a unique opportunity to uncover genetic modifiers of disease progression, including rare variants in genes such as APOE and RELN.

Friction variation creates Tête de Moine’s signature cheese flowers

Tête de Moine, a semi-hard Swiss cheese that often finds its way onto charcuterie boards and salads, not only brings a rich, nutty and creamy flavor, but also adds a dramatic flare to the presentation. Instead of slicing, this cheese is shaved into delicate rosettes using a tool called a Girolle whose rotating blade gently scrapes thin layers of cheese into ruffled curls. These pretty cheese flowers are known to enhance the flavor and texture due to their high surface-to-volume ratio.

The unusual way Tête de Moine forms wrinkles when shaved, piqued the interest of a team of physicists who, in a study published in Physical Review Letters, set out to investigate the physical mechanisms behind these intricate shapes.

Similar morphogenetic patterns can be observed in the frilly edges of leaves, fungi, corals, or even torn , but the mechanisms that explain the similar shapes in these materials fail to account for the distinctive physical properties of .

How rapid DNA repair in plants protects genomes from internal threats

Scientists have uncovered a critical role for rapid DNA repair in maintaining genome stability. A new study reveals that repair of double-strand breaks (DSBs) in nuclear DNA in plants serves as a powerful safeguard against the integration of foreign DNA from chloroplasts—a phenomenon that, while important for evolution, can be highly destabilizing to the genome. The research expands our knowledge about plant genome evolution and also has relevance to the medical field.

The findings, presented by Dr. Enrique Gonzalez-Duran and Prof. Dr. Ralph Bock from the Max Planck Institute of Molecular Plant Physiology in Nature Plants, shed new light on endosymbiotic gene transfer (EGT)—an ongoing evolutionary process in which genes from organelles such as chloroplasts and mitochondria are relocated into the nuclear genome.

While successful gene transfers help the nucleus to better coordinate its function with that of the organelles, they also pose risks: Mutations arising from DNA insertion can disrupt essential nuclear genes and provoke harmful rearrangements.

Breakthrough DNA-based supercomputer runs 100 billion tasks at once

The boundaries of computing are shifting as biology fuses with technology. At the center of this new frontier is an emerging concept: a liquid computer powered by DNA. With the ability to support more than 100 billion unique circuits, this system could soon transform how we detect and diagnose disease.

While DNA is best known for encoding life, researchers are now exploring its potential as a computing tool. A team led by Dr. Fei Wang at Shanghai Jiao Tong University believes DNA can do much more than carry genetic instructions.

Their study, recently published in Nature, reveals how DNA molecules could become the core components of new computing systems. Rather than just holding genetic data, DNA could behave like wires, instructions, or even electrons inside biological circuits.

17y Younger Biological Age (Full Lab Results And Analysis; Test #3 in 2025)

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Candidate drug that boosts protective brain protein in mice has potential to treat Alzheimer’s disease

As researchers work to improve treatment of Alzheimer’s disease, new research by UCLA Health identified a candidate drug that reduces levels of a toxic form of a protein in the brain caused by the disease and improved memory in mice by boosting production of a protective protein.

In a study published in npj Drug Discovery, UCLA Health researchers targeted the protein clusterin (CLU), which is crucial in preventing the build-up of amyloid-beta plaques and tau proteins that disrupt communication between and lead to memory impairment—a hallmark symptom of Alzheimer’s disease.

More than a decade ago, a variant of the gene that encodes clusterin was identified as the third strongest genetic risk factor for late-onset Alzheimer’s disease. It was recently reported that increased CLU protein could provide protection against Alzheimer’s disease and .

Want to live to 100? Skip the gym, this daily habit matters more; longevity expert reveals

Forget the gym—living longer could hinge on simple daily habits. Dr. Gareth Nye emphasizes whole-day activity, clean eating, quality sleep, and genetic awareness as the real drivers of longevity. Standing desks, frozen veggies, and knowing your family health risks might be more effective than intense workouts in boosting life expectancy and preventing chronic illness.

Daylight can boost the immune system’s ability to fight infections

A breakthrough study, led by scientists at Waipapa Taumata Rau, University of Auckland, has uncovered how daylight can boost the immune system’s ability to fight infections.

The team focused on the most abundant immune cells in our bodies, called neutrophils, which are a type of white blood cell. These cells move quickly to the site of an infection and kill invading bacteria.

The researchers used zebrafish, a small freshwater fish, as a , because its is similar to ours and the fish can be bred to have transparent bodies, making it easy to observe biological processes in real time.

Natural short sleepers have a genetic mutation, finds new study

Not everyone needs 8 hours of sleep to function properly. Some people can feel well-rested and show no negative effects of sleep deprivation, even after just 4 hours of sleep, which is likely the result of a genetic mutation.

A recent study has reported that a mutation in salt-induced kinase 3 (hSIK3-N783Y)—a gene critical for regulating sleep duration and depth—may be the reason why some people are natural short sleepers (NSS).

The findings of this study are published in Proceedings of the National Academy of Sciences.