Using the CRISPR gen-editing technique, a team of researchers altered the flowers on morning glory plants from purple to white. This is the first time it’s been used to change a plant’s color.
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Category: genetics – Page 471
Brain scientists have identified a genetic programme that controls the way our brain changes throughout life.
The programme controls how and when brain genes are expressed at different times in a person’s life to perform a range of functions, the study found.
Experts say the timing is so precise that they can tell the age of a person by looking at the genes that are expressed in a sample of brain tissue.
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I was thinking about this the other day. How far off is using CRISPR for cosmetic changes? permanently changing of eye color, hair color, skin (although that one is gonna be a lightning rod), etc…
In a world-first, Japanese scientists have used the revolutionary CRISPR, or CRISPR/Cas9, genome- editing tool to change flower colour in an ornamental plant. Researchers from the University of Tsukuba, the National Agriculture and Food Research Organization (NARO) and Yokohama City University, Japan, altered the flower colour of the traditional Japanese garden plant, Japanese morning glory (Ipomoea nil or Pharbitis nil), from violet to white, by disrupting a single gene. This research highlights the huge potential of the CRISPR/Cas9 system to the study and manipulation of genes in horticultural plants.
Japanese morning glory, or Asagao, was chosen for this study as it is one of two traditional horticultural model plants in the National BioResource Project in Japan (NBRP). Extensive genetic studies of this plant have already been performed, its genome sequenced and DNA transfer methods established. In addition, as public concern with genetic technologies such as CRISPR/Cas9 is currently a social issue in Japan, studies using this popular and widely-grown plant may help to educate the public on this topic.
The research team targeted a single gene, dihydroflavonol-4-reductase-B (DFR-B), encoding an anthocyanin biosynthesis enzyme, that is responsible for the colour of the plant’s stems, leaves and flowers. Two other, very closely related genes (DFR-A and DRF-C) sit side-by-side, next to DFR-B. Therefore, the challenge was to specifically and accurately target the DFR-B gene without altering the other genes. The CRISPR/Cas9 system was used as it is currently the most precise method of gene editing.
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UCLA scientists working with middle-aged fruit flies say they were able to improve the insects’ health while markedly slowing down their aging process. The team thinks its technique could eventually help delay the onset of Parkinson’s disease, Alzheimer’s disease, cancer, stroke, cardiovascular disease, and other age-related diseases in humans.
The researchers zeroed in on mitochondria, which often become damaged with age. When cells can’t eliminate the damaged mitochondria, they can become toxic and contribute to a wide range of age-related diseases, said David Walker, Ph.D., a UCLA professor of integrative biology and physiology, and the study’s senior author.
Dr. Walker and his colleagues found that as fruit flies reach middle age—about one month into their two-month lifespan—their mitochondria change from their original small, round shape.
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A new study published by scientists at the Salk Institute recently shows how that changes in the nucleolus of progeria cells and normally aged cells share some characteristics that may allow them to be used as a biomarker for biological age[1].
What is Progeria?
Hutchinson-Gilford progeria is a rare genetic disease that causes people to suffer from aging-like symptoms on an accelerated timescale compared to regular aging. Whilst it shares similarities with regular aging it is not accelerated aging per se, but the outcome is much the same.
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A Stanford team has launched a new challenge on the Eterna computer game. Players will design a CRISPR-controlling molecule, and with it open the possibility of new research and therapies.
A team of researchers at the Stanford University School of Medicine has launched a new challenge for the online computer game Eterna in which players are being asked to design an RNA molecule capable of acting as an on/off switch for the gene-editing tool CRISPR/Cas9.
Molecular biologists will then build and test the actual molecules, based on the most promising designs provided by the players.
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It is important to note that none of the embryos were allowed to develop for more than a few days, and that the team never had any intention of implanting them into a womb. However, it seems that this is largely due to ongoing regulatory issues, as opposed to issues with the technology itself.
In the United States, all efforts to turn edited embryos into a baby — to bring the embryo to full term — have been blocked by Congress, which added language to the Department of Health and Human Services funding bill that forbids it from approving any such clinical trials.
Related: CRISPR-CAS9: The Future of Genetic Engineering (Infographic)
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A Chicagoland hospital system has added something new to its patients’ annual checkups: the option to get a genetic test.
Until now, DNA tests have tended to live either in the consumer realm or through referrals to specialists when a patient brings it up.
NorthShore University HealthSystem wants to bring that conversation about genetics into every doctor’s office during annual checkups.
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