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Category: genetics – Page 472

Rejuvenation: The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process

Here, we will first summarize the experimental achievements over the last 7 years in cell and animal rejuvenation. Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath’s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rodents published afterwards will be very briefly mentioned. The only in vivo study reporting that a number of organs of old progeric mice can be rejuvenated by cyclic partial reprogramming will also be described in some detail. The cumulative DNA damage theory of aging postulates that as an animal ages, toxic reactive oxygen species generated as byproducts of the mitochondria during respiration induce a random and progressive damage in genes thus leading cells to a progressive functional decline. The epigenetic model of aging postulates that there are epigenetic marks of aging that increase with age, leading to a progressive derepression of DNA which in turn causes deregulated expression of genes that disrupt cell function. The cumulative DNA damage model of aging fails to explain the resetting of the aging clock at the time of conception as well as the continued vitality of species as millenia go by. In contrast, the epigenetic model of aging straightforwardly explains both biologic phenomena. A plausible initial application of rejuvenation in vivo would be preventing adult individuals from aging thus eliminating a major risk factor for end of life pathologies. Further, it may allow the gradual achievement of whole body rejuvenation.

AP-NORC Poll: Most support gene editing to protect babies

WASHINGTON (AP) — Most Americans say it would be OK to use gene-editing technology to create babies protected against a variety of diseases — but a new poll shows they’d draw the line at changing DNA so children are born smarter, faster or taller.

A month after startling claims of the births of the world’s first gene-edited babies in China, the poll by The Associated Press-NORC Center for Public Affairs Research finds people are torn between the medical promise of a technology powerful enough to alter human heredity and concerns over whether it will be used ethically.

Jaron Keener, a 31-year-old exhibit designer at Pittsburgh’s Carnegie Museum of Natural History, said he’s opposed to “rich people being able to create designer babies.”

A New Study Just Solved One of The Greatest Mysteries of DNA Replication

Replication is nature’s greatest magic trick. Watch closely, and before your very eyes you’ll see a single cell blur into two virtually identical copies. Presto.

After more than half a century of research on molecular genetics, it would be easy to assume we’ve had this biological sleight-of-hand all figured out — but it’s not the case.

Now, by applying cutting edge technology, researchers have uncovered crucial details showing how DNA times its own replication.

What to expect in 2019: science in the new year

China could emerge as the world’s biggest spender on research and development, after adjusting for the purchasing power of its currency, once countries publish their 2018 spending data in late 2019. Outlays on science in China have accelerated since 2003, although the country still trails behind the United States on measures of research quality. Over in Europe, officials will try to agree on how to disburse a proposed €100 billion (US$110 billion) through the European Union’s next research-funding programme, Horizon Europe, which begins in 2021. It’s unclear how fully UK researchers will be able to participate, as uncertainty over Brexit continues to plague the country.

Gene-editing, open access and a biosafety rethink are set to shape research.

Should We Replace Ourselves? | Zoltan Istvan vs. JFG, TPS #257

I was in a really interesting 1-hour debate yesterday with Jean-Francois Gariépy who runs a well-known YouTube channel The Public Space, sometimes associated with the Alt-Right. We discussed #transhumanism. I think the debate caught a lot of people by surprise. While I believe in and embrace total diversity, I despise the oppression of human biology and death, and advocate for any means possible to overcome it—including genetic modification and merging with machines. The debate makes me look like the aggressor. But it only proves what I’ve always said, that issues of race and traditional cultural bigotry are minor compared to the issues of humanity battling aging and death itself. All of us are currently in a war to not die:

An important debate on whether or not humanity should play with their own genes. Guest: Zoltan Istvan, transhumanist.

Zoltan on Twitter: https://twitter.com/zoltan_istvan
Zoltan on the Web: http://www.zoltanistvan.com/

The Transhumanist Wager by Zoltan Istvan: http://www.zoltanistvan.com/TranshumanistWager.html

JF’s book, The Revolutionary Phenotype, is out!

Continue reading “Should We Replace Ourselves? | Zoltan Istvan vs. JFG, TPS #257” | >

Bioquark Inc — Ectocrine Technologies — Mosquitos — Ira Pastor

New program coming on-line at Bioquark Inc. (www.bioquark.com) — Ectocrine interactions (the“Ectocrinome”) represents a completely unexplored area related to human health

https://www.prweb.com/releases/bioquark_inc_and_ectocrine_te…004155.htm


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