Lifeboat Foundation

S cientists have edited human embryos for the first time in the UK to discover a “master gene” that underpins successful pregnancies. The “game-changing” research promises improved IVF outcomes and a breakthrough in understanding why so many pregnancies fail.

The Government-funded investigation, undertaken by the Francis Crick Institute, is the first to prove that gene editing can be used to study the genetic behaviour of human embryos in their first few days of life.

Researchers studied 14,000 Icelanders and found that men passed on one new mutation for every eight months of age, compared with women who passed on a new mutation for every three years of age.

The figures mean that a child born to 30-year-old parents would, on average, inherit 11 new mutations from the mother, but 45 from the father.

Researchers at the Institute of Molecular Biology (IMB) in Mainz, Germany, have made a breakthrough in understanding the origin of the ageing process. They have identified that genes belonging to a process called autophagy — one of the cells most critical survival processes — promote health and fitness in young worms but drive the process of ageing later in life. This research published in the journal Genes & Development gives some of the first clear evidence for how the ageing process arises as a quirk of evolution. These findings may also have broader implications for the treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease where autophagy is implicated. The researchers show that by promoting longevity through shutting down autophagy in old worms there is a strong improvement in neuronal and subsequent whole body health.

Getting old, it’s something that happens to everyone and nearly every species on this planet, but the question is, should it? In a recent publication in the journal Genes & Development titled “Neuronal inhibition of the autophagy nucleation complex extends lifespan in post-reproductive C. elegans,” the laboratory of Dr Holger Richly at IMB, has found some of the first genetic evidence that may put this question to rest.

As Charles Darwin explained, natural selection results in the fittest individuals for a given environment surviving to breed and pass on their genes to the next generation. The more fruitful a trait is at promoting reproductive success, the stronger the selection for that trait will be. In theory, this should give rise to individuals with traits which prevent ageing as their genes could be passed on nearly continuously. Thus, despite the obvious facts to the contrary, from the point of evolution ageing should never have happened. This evolutionary contradiction has been debated and theorised on since the 1800s. It was only in 1953 with his hypothesis of antagonistic pleiotropy (AP) that George C. Williams gave us a rational explanation for how ageing can arise in a population through evolution. Williams proposed that natural selection enriches genes promoting reproductive success but consequently ignores their negative effects on longevity.

Continue reading “Why we did not evolve to live forever: Unveiling the mystery of why we age” »

Summary: Researchers are testing a new vaccine and oral medication that could delay or prevent Alzheimer’s disease from developing in those with a genetic predisposition.

Source: Keck Medicine USC.

The Keck School of Medicine of USC launches a study exploring whether two different therapies can prevent a leading cause of death.

Modern Meadow believes leather is a “co-product of the meat industry.” You can’t get cattle hide without stripping it from meat. Rather than configuring new ways to utilize polymers, the Brooklyn-based company genetically creates proteins similar to bovine collagen. As Inventionr reports :

Modern Meadow has formulated a method of activating the building blocks of proteins to form fibres without using natural fibroblasts. Once the fibres form, they can as well be assembled, according to its intended purposes, into fine sheets of leather. Once the process reaches this point, other processes like tanning and dyeing can proceed in the normal way.

Continue reading “This Brooklyn-Based Startup Is Growing Leather In Labs—Cruelty Free” »

Researchers announced yesterday that they discovered a #genetic #brain #aging #clock that controls how our brains age. The clock controls brain aging according to a precise timetable. This discovery holds promise that scientists can prevent brain aging by stopping the clock.

Summary: Researchers announced yesterday that they discovered a genetic brain aging clock that controls how our brains age. The clock controls aging in our brains according to a precise timetable. This discovery holds promise that scientists can prevent brain aging by stopping the clock.

Imagine keeping your mind sharp as a teenager’s while you grow older, even into your twilight years.

Continue reading “Researchers Discover Key to Brain Aging” »

My new policy article for the HuffPost on why more than ever we need to avoid war and armed conflict:

Some of the early years of my adult life were in conflict zones as a journalist—which included covering the Pakistan/Indian Kashmir conflict for the National Geographic Channel and The New York Times Syndicate. War zones are terrifying. One always is worried about bullying soldiers, speeding armed military vehicles, stray bullets, and whether there’s a roadside bomb on your path. Anyone that approaches you is suspect and could be carrying ready-to-detonate explosives.

One thing conflict zones teach you is that freedom is precious. The nearly 70-year Kashmir conflict has approximately a half million soldiers involved, so even if they’re supposedly on your side (depending on what country you’re in), you still feel under siege. My time in certain parts of Sudan, Israel, Palestine, Zimbabwe, Lebanon, Sri Lanka, Eritrea, Mali, and Yemen left me with the same feeling.

Continue reading “The Libertarian Futurist’s Case for Avoiding War and Military Entanglements” »

Put simply: Yes. Here’s why, and the nitty gritty of how the gene-editing tool works.

Short for Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR is a revolutionary gene editing technique that’s taken the scientific world by storm. Both ultra-precise and easy to access, CRISPR could be the next step towards wiping out genetically inherited diseases and even curing cancers. A host of exciting CRISPR concepts are currently undergoing clinical trials and proof-of-concept experiments, with one particularly controversial focus — human embryos.

A “cut and paste” concept

While there have been rumours coming out of China for years, US scientists have now confirmed that the first attempts to create genetically modified human embryos have been a success. Led by researchers at the Oregon Health and Science University in Portland, the study used CRISPR to change the DNA of multiple one-cell human embryos. Basically, this allowed them to “snip” out segments of a particular genome and switch them with customised replacements. As in previous cases, the embryos were terminated several days after creation to prevent them from developing into foetuses.

Continue reading “Is Human Genetic Modification Possible?” »