Circa 2019 face_with_colon_three
Scientists at Harvard Medical School and Boston Children’s Hospital have used a novel gene-editing approach to salvage the hearing of mice with genetic hearing loss and succeeded in doing so without any apparent off-target effects as a result of the treatment.
NSD2 is the fourth protective factor of cellular senescence that our team has identified,” said Professor Mitsuyoshi Nakao. “With the discovery that NSD2 protects against cellular senescence, this study clarifies a basic mechanism of aging.
Researchers from Kumamoto University in Japan have used comprehensive genetic analysis to find that the enzyme NSD2, which is known to regulate the actions of many genes, also works to block cell aging. Their experiments revealed 1) inhibition of NSD2 function in normal cells leads to rapid senescence and 2) that there is a marked decrease in the amount of NSD2 in senescent cells. The researchers believe their findings will help clarify the mechanisms of aging, the development of control methods for maintaining NSD2 functionality, and age-related pathophysiology.
As the cells of the body continue to divide (cell reproduction), their function eventually declines and they stop growing. This cellular senescence is an important factor in health and longevity. Cell aging can also be stimulated when genomic DNA is damaged by physical stress, such as radiation or ultraviolet rays, or by chemical stress that occurs with certain drugs. However, the detailed mechanisms of aging are still unknown. Cell aging can be beneficial when a cell becomes cancerous; it prevents malignant changes by causing cellular senescence. On the other hand, it makes many diseases more likely with age. It is therefore important that cell aging is properly controlled.
Although senescent cells lose their proliferative ability, it has recently become clear that senescent cells secrete various proteins that act on surrounding cells to promote chronic inflammation and cancer development. Since senescent cells are more active than expected, cellular aging is thought to be responsible for whole body aging. This idea has been supported by reports of systemic aging suppression in aged mice after removal of accumulated senescent cells. In other words, if you can control cell aging, you may be able to control the progression of aging throughout the body.
A small DNA-testing company that just months ago was trying to get its footing in consumer genetics is now part of an effort to make U.K. hospitals safer during the pandemic.
The company, DnaNudge, won a 161-million pound ($211 million) order for 5,000 machines and a supply of cartridges to test patients for the new coronavirus in hundreds of the National Health Service hospitals.
Circa 2019
A common gene-editing enzyme could be used to disable RNA viruses such as flu or Ebola.
Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of—and a treatment for—a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy.
The technology, tailored to the patient’s own genetic code at a single cell level, helped the researchers characterize an unknown mutation in a gene called JAK1 that caused the patient’s immune system to be permanently turned on, resulting in rashes over much of her skin, growth abnormalities, kidney failure, allergic hypersensitivities, and an unusual inflammatory condition throughout the digestive tract.
The study, led by Dusan Bogunovic, Ph.D., Associate Professor of Microbiology, and Pediatrics, at the Icahn School of Medicine at Mount Sinai, faculty member of The Mindich Child Health and Development Institute and the Precision Immunology Institute at Mount Sinai, and Director of the Center for Inborn Errors of Immunity, was published in the August 3 issue of the journal Immunity. The discovery points toward new ways to study how genetic diseases manifest and presents a model of personalized diagnosis and treatment for patients with genetic diseases.
The advent of DNA sequencing has given scientists a clearer insight into the interconnectedness of evolution and the web-like path that different organisms take, splitting apart and coming back together. Tony Capra, associate professor of biological sciences, has come to new conclusions about the influence of Neanderthal DNA on some genetic traits of modern humans.
The article “Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations” was published in the journal Nature Ecology & Evolution on July 27.
The ancestors of all modern humans lived across the African continent, until approximately 100,000 years ago when a subset of humans decided to venture further afield. Neanderthals, an extinct relative of modern humans, had been longtime residents of Europe and central and south Asia; their ancestors had already migrated there 700,000 years previously. The humans who moved into central Asia and the Middle East encountered and reproduced with Neanderthals. Neanderthal DNA is present in some modern humans, and now research shows that can sometimes be a good thing.
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What is CAR-T therapy?
CAR-T therapy involves genetically engineering patient T-cells so that they express a chimeric antigen receptor (CAR).
CARs consist of a protein that binds to cancer cells, usually an antibody, fused to the signaling domain from a T-cell receptor (TCR). The idea is that a killer T-cell expressing the CAR engages cancer cells and eliminates them.
With these new findings scientists can potentially better understand the subtle changes that can occur in genes and brain circuits that can lead to mental health disorders such as anxiety and autism spectrum disorders.
Although physically very different, research has found that the brains of flies, mice and humans are similar in how they form and how they function. Data has shown that the genetic mechanisms that underlie the brain development of insects and mammals are very similar but this can be interpreted in two different ways, where some believe it provides evidence of one single ancestor for both mammals and insects and others think it could support the theory that brains evolved multiple times independently.
Published in the journal Proceedings of the National Academy of Sciences (PNAS), this collaborative study between King’s College London, University of Arizona, University of Leuven and Leibniz Institute DSMZ has provided strong evidence that the mechanisms that regulate genetic activity required for the formation of brain areas important to control behavior, is the same for insects and mammals.
A disease-detecting “precision health” toilet can sense multiple signs of illness through automated urine and stool analysis, according to a new study.
The “smart toilet” isn’t the kind that lifts its own lid in preparation for use; this toilet includes technology that can detect a range of disease markers in stool and urine, including those of some cancers, such as colorectal or urologic cancers.
The device could hold particular appeal for people genetically predisposed to certain conditions, such as irritable bowel syndrome, prostate cancer, or kidney failure, and want to keep on top of their health.
