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Category: genetics – Page 270

Research Shows Investigational Cancer Drug Can Boost Regeneration of Damaged Nerves After Spinal Cord Injury

Scientists have demonstrated that a brain-penetrating candidate drug currently in development as a cancer therapy can promote regeneration of damaged nerves after spinal trauma.

The research used cell and animal models to show that when taken orally the candidate drug, known as AZD1390, can block the response to DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

A New Technology Could Help Solve a DNA Mystery

Researchers from Oxford Nanopore Technologies, Weill Cornell Medicine, and the New York Genome Center have created a new technique to evaluate the three-dimensional structure of the human DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

The LightCycler® 480 real-time PCR system: a versatile platform for genetic variation research

Circa 2008

From endpoint fluorescence to melting curve analysis.

Today’s research on somatic, genetic and epigenetic variation in eukaryotic cells requires fast, accurate and cost-effective methods for screening large numbers of samples or loci in parallel. Variations identified by genomic sequencing or array studies need to be subsequently confirmed and validated.

Real-time PCR has become a well established technology for this purpose. The plate-based LightCycler 480 system offers a broad selection of methods and applications (Fig. 1).

Dr Dana Merriman, PhD — UW-Oshkosh — Hibernation Biology & Applications In Human Health & Resilience

Hibernation Biology & Applications In Human Health & Resilience — Dr. Dana K. Merriman, Ph.D., Distinguished Professor Emerita of Biology; Director of the Squirrel Colony, UW-Oshkosh.

Dr. Dana K. Merriman Ph.D. (www.uwosh.edu/facstaff/merriman/VaughanHome), is Distinguished Professor Emerita of Biology, and Director of the Squirrel Colony, at University of Wisconsin Oshkosh, and Adjunct Professor of Ophthalmology & Visual Sciences, Medical College of Wisconsin.

With her BA in Biological Science and her PhD in Physiology and Cell Biology, both from University of California-Santa Barbara, as well as having spent time as a Postdoctoral Fellow at University of Utah Health Sciences Center, a core focus of Dr. Merriman’s laboratory research over the years has been the development of a captive breeding colony of the 13-lined ground squirrels.

This unique, one-of-a-kind captive breeding program, due to this species very unique cone-dominant, diurnal visual system, as well as their impressive physiological ability to survive in hibernation for over six months without food or water, has served investigators with animals and custom-dissected tissues from the US, Asia, and Europe for decades, as well as been core to Dr Merriman’s own work on vision, including cone cell biology and retinal function during the metabolic state transitions associated with hibernation.

Over the years, Dr. Merriman expanded her research horizon well outside of vision, into neuroscience, and in recent years she has collaborated on studies of muscle physiology, viral genomics, molecular biology of transposable elements, and comparative genetics of the control of coat patterning.

Continue reading “Dr Dana Merriman, PhD — UW-Oshkosh — Hibernation Biology & Applications In Human Health & Resilience” | >

Scientists Have Sequenced the DNA of a 2000-Year-Old Human From Pompeii

Research that was recently published in Scientific Reports presents the first human genome that has been successfully sequenced from a person who passed away in Pompeii, Italy, after Mount Vesuvius’ explosion in the year 79 CE. Only little segments of mitochondrial DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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