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Category: genetics – Page 269

Longevity Research is an Economic Necessity

It is vital to recognize the immediate economic importance of i nvesting in longevity and healthy-aging sciences.

Aging itself is a complex series of at least 300 biological processes involving more than 10% of our genetic makeup. It follows that methods to combat these effects must be a combination of sciences, from biotech to biophysics and pharmaceuticals. There is no single “silver bullet” solution.

Aging, along with the physical and mental decay that accompanies it, is still widely regarded as a natural and inevitable thing. It is not, it is a degenerative disease in which the physical integrity and structure of our cells decay each time they divide to replace old ones or as part of any healing process.

Scientists engineer a bacteria to produce a drug used to treat Parkinson’s disease

The results of the study could lead to new treatment options. In a groundbreaking new study published in the journal Nature on Thursday, researchers have compared the brain cells of patients who had died from either Parkinson’s disease or dementia to people unaffected by the disorders and found which brain cells are responsible for both conditions.

A team of researchers has created a bacteria that can produce a steady and consistent source of medicine inside a patient’s gut, suggesting the possibility for genetically edited bacteria to be an efficient Parkinson’s disease treatment.

Moreover, the researchers have shown via preclinical experiments that the novel treatment technique is not only safe and well-tolerated, but it also reduces side effects that can occur when other treatments are utilized.

An engineered probiotic

For long, scientists have been experimenting with ways of engineering bacteria to fit our needs for decades. The new research is the latest example of that.

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The Surprisingly Sophisticated Mind Of An Insect

Quinn SenaAuthor.

Tenor.

Jose Ruben Rodriguez Fuentes shared a link.

Carrie Arnold is a freelance health and science writer living in Virginia.

At the age of 20, I committed my first mass murder. I didn’t, of course, mean to kill anyone. But my good intentions meant nothing to the small mound of deceased fruit flies in the bottom of the vial.

My goal was simply to anesthetize them and then search their wrinkled, vellum wings and bulging eyes for mutations. It was a classic introductory genetics experiment, one taught to countless aspiring biologists for a century. I doused a cotton ball with ether, the fruity-smelling liquid that would render the flies temporarily unconscious (and easier to count). The instructor warned us to make sure the flies were completely knocked out, so that they didn’t wake up mid-experiment. So I left the ether-soaked cotton on the vial an extra minute or two. Just to be safe.

Continue reading “The Surprisingly Sophisticated Mind Of An Insect” | >

Lab-Grown Brain Experiment Reverses The Effects of Autism-Linked Gene

Scientists have uncovered changes in neurological structure that could underlie the autism spectrum disorder known as Pitt Hopkins syndrome, thanks to the help of lab-grown brains developed from human cells.

Furthermore, the researchers were able to recover lost genetic functions through the use of two different gene therapy strategies – hinting at the possibility of treatments that could one day give those with the condition new options in improving their quality of life.

Pitt Hopkins syndrome is a neurodevelopmental condition stemming from a mutation in a DNA-management gene called transcription factor 4 (TCF4). Classed on the autism spectrum on account of its severe impact on motor skills and sensory integration, it’s a complex condition that presents with a range of severities.

Could the blueprint for life have been generated in asteroids?

Using new analyses, scientists have just found the last two of the five informational units of DNA and RNA that had yet to be discovered in samples from meteorites. While it is unlikely that DNA could be formed in a meteorite, this discovery demonstrates that these genetic parts are available for delivery and could have contributed to the development of the instructional molecules on early Earth. The discovery, by an international team with NASA researchers, gives more evidence that chemical reactions in asteroids can make some of life’s ingredients, which could have been delivered to ancient Earth by meteorite impacts or perhaps the infall of dust.

All DNA and RNA, which contains the instructions to build and operate every living being on Earth, contains five informational components, called nucleobases. Until now, scientists scouring had only found three of the five. However, a recent analysis by a team of scientists led by Associate Professor Yasuhiro Oba of Hokkaido University, Hokkaido, Japan, identified the final two nucleobases that have eluded scientists.

Nucleobases belong to classes of organic molecules called purines and pyrimidines, which have a wide variety. However, it remains a mystery why more types haven’t been discovered in meteorites so far.

Dr Katcher’s E5 Experiment May 2022 Update | Review

Not an amazing update. All female rats are not getting the results the previous group of males got. To my knowledge human trials are still actively being set up for late this year.

In this video we report on the May 2022 update from Dr. Katcher’s experiment with E5, where he is testing to see how long the rats will stay alive if they are given an E5 injection every 90 days.

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Links for this video.
Sign up for the newsletter from NTZ Publishing here:
https://www.ntzplural.com/newsletter.
Reversing age: dual species measurement of epigenetic age with a single clock.
https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
The entry on Dr Josh Mitteldorf’s Aging Matters blog.

Age Reduction Breakthrough

Our discussion of original paper.
https://youtu.be/DokfEzQt_wk.
Playlist for Dr. Katcher August 2021 Interview Series.

Playlist 1 for Dr. Katcher.
https://www.youtube.com/playlist?list=PLkfzM7KJv6vaIQZ_n3WS6FHTpBtfS2lzw.

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Researchers find a genetic cause for lupus

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A team of international researchers have identified a genetic cause of lupus. Researchers of the study pinpointed that DNA mutations in a gene that senses viral RNA represents one cause of the chronic condition, affecting approximately 1 in 1,000 people living in the UK. It is important to note that this genetic cause is not the sole trigger for everyone affected by lupus.

Researchers of the study sequenced the whole DNA genome of a juvenile systemic lupus erythematosus (JSLE) patient called Gabriela, who was diagnosed with severe lupus at the age of seven. A severe case such as this, with early onset of symptoms, is a rarity and is commonly associated with a single genetic cause, unlike adult-onset lupus.

The researchers that carried out the genetic analysis identified a single point mutation in the Toll Like Receptor 7 (TLR7) gene. Furthermore the researchers discovered other cases of severe lupus where this gene was also mutated.

YouthBio CEO: The time is right to develop epigenetic reprogramming therapies

Earlier this month, we brought you the news that epigenetic reprogramming startup YouthBio Therapeutics had emerged from stealth. The company shed some light on its plans to develop epigenetic reprogramming therapies for age-related diseases by rejuvenating certain cells in our bodies. YouthBio aims to achieve this rejuvenation by developing gene therapies that enable partial cellular reprogramming – an area of longevity science that is now attracting significant commercial interest.

Longevity. Technology: Cellular reprogramming refers to the process of returning adult cells to a “pluripotent” state: blank, embryonic-like cells that can become any cell in the body. This reprogramming can be achieved using techniques based on the discovery of Yamanaka factors.

Meteorites could have brought all 5 genetic ‘letters’ of DNA to early Earth

These key building blocks of life were found in space rocks, scientists confirm.

Key building blocks of DNA that previous research mysteriously failed to discover in meteorites have now been discovered in space rocks, suggesting that cosmic impacts might once have helped deliver these vital ingredients of life to ancient Earth.

DNA is made of four main building blocks — nucleobases called adenine (A), thymine (T), cytosine © and guanine (G). DNA’s sister molecule, RNA, also uses A, C and G, but swaps out thymine for uracil (U). Scientists wondering whether meteorites might have helped deliver these compounds to Earth have previously looked for nucleobases in space rocks, but until now, scientists had only detected A and G in space rocks, and not T, C or U.